Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study.

There are currently no licensed vaccines for norovirus, a leading cause of epidemic and endemic gastroenteritis worldwide. Clinical advancement of promising vaccine candidates from phase 2 studies to phase 3 field trials has been hampered by the lack of robust immunological correlates of protection. Here, we conducted a phase 2b randomized, placebo-controlled vaccination and challenge study to ass...

May 14 2025 40367195

Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma.

Allergic asthma in children is typically associated with house dust mites (HDM) as the key allergen. Nevertheless, the diagnostic rate remains below 60% due to the absence of specific symptoms and diagnostic markers, which hinders the implementation of targeted personalized therapies. This study investigates immunological features of asthma with house dust mite (HDM) sensitisation in children, aim...

May 14 2025 40368964
Artificial Intelligence-Derived Electrocardiographic Age Predicts Mortality in Adults With Congenital Heart Disease.

BACKGROUND: Artificial intelligence (AI) can be used to estimate age from the electrocardiogram (AI-ECG age). The difference between AI-ECG age and ch...

May 14 2025 40373518
Generative Deep Learning Design of Single-Domain Antibodies Against Venezuelan Equine Encephalitis Virus.

BACKGROUND/OBJECTIVES: Venezuelan equine encephalitis virus (VEEV) represents a significant biothreat with no FDA-approved vaccine currently available...

May 14 2025 40407693
Estimating PM Exposures and Cardiovascular Disease Risks in the Yangtze River Delta Region Using a Spatiotemporal Convolutional Approach to Fill Gaps in Satellite Data.

Accurate estimation of ambient PM concentrations is crucial for assessing air quality and health risks, particularly in regions with limited ground-ba...

May 14 2025 40423471
Nanobodies: From Discovery to AI-Driven Design.

Nanobodies, derived from naturally occurring heavy-chain antibodies in camelids (VHHs) and sharks (Vs), are unique single-domain antibodies that have ...

May 14 2025 40427736
Efficient Design of Affilin Protein Binders for HER3.

Engineered scaffold-based proteins that bind to concrete targets with high affinity offer significant advantages over traditional antibodies in theran...

May 14 2025 40429825
Deep Learning Models for Multi-Part Morphological Segmentation and Evaluation of Live Unstained Human Sperm.

To perform accurate computer vision quality assessments of sperm used within reproductive medicine, a clear separation of each sperm component from th...

May 14 2025 40431886
Big Data and the Computational Social Science of Entrepreneurship and Innovation

As large-scale social data explode and machine-learning methods evolve, scholars of entrepreneurship and innovation face new research opportunities ...

Controllable Image Colorization with Instance-aware Texts and Masks

Recently, the application of deep learning in image colorization has received widespread attention. The maturation of diffusion models has further a...

Boosting Zero-shot Stereo Matching using Large-scale Mixed Images Sources in the Real World

Stereo matching methods rely on dense pixel-wise ground truth labels, which are laborious to obtain, especially for real-world datasets. The scarcit...

Dynamic Snake Upsampling Operater and Boundary-Skeleton Weighted Loss for Tubular Structure Segmentation

Accurate segmentation of tubular topological structures (e.g., fissures and vasculature) is critical in various fields to guarantee dependable downs...

Empowering Vision Transformers with Multi-Scale Causal Intervention for Long-Tailed Image Classification

Causal inference has emerged as a promising approach to mitigate long-tail classification by handling the biases introduced by class imbalance. Howe...

Precise Detection of Carbapenem-Resistant and Hypervirulent Using MOF-Derived Bimetallic Nanocube Hybrid Nanosheet.

Carbapenem resistance and hypervirulence represent two distinct evolutionary pathways in , posing significant challenges in clinical settings. Of part...

May 13 2025 40313190
Redefining Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer in the Era of Novel Antibody-Drug Conjugates.

The advent of next-generation antibody-drug conjugates (ADCs), particularly trastuzumab deruxtecan (T-DXd), has transformed our understanding of human...

May 13 2025 40359470
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.

Despite the success of BCMA-targeting CAR-Ts in multiple myeloma, patients with high-risk cytogenetic features still relapse most quickly and are in u...

May 13 2025 40359480
Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies.

Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, of...

May 13 2025 40361241
Indirect Detection of Swine Influenza Activity in Porcine Blood Using Raman Spectroscopy and Machine Learning.

Over the past decade, several swine influenza variants, including H1N1 and H1N2, have been periodically detected in swine. Raman spectroscopy (RS) off...

May 13 2025 40364571
Machine Learning Techniques Applied to COVID-19 Prediction: A Systematic Literature Review.

COVID-19 was one of the most serious global public health emergencies in recent years, and its extremely fast spreading speed had a profound negative ...

May 13 2025 40428133
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