Latest AI and machine learning research in covid-19 for healthcare professionals.
Accurate interpretation of missense variants remains a significant challenge hindering genomic diagnosis. While state-of-the-art machine learning and deep learning predictors offer high accuracy, they often lack the transparency required for clinical evidence weighting. To bridge this gap between accuracy and clinical utility, we developed AlphaRING-X. AlphaRING-X is an open-source framework that ...
Diabetic foot ulcers (DFU) constitute a major complication arising from diabetes mellitus. Emerging research findings have underscored the pivotal contribution of cellular senescence to the pathophysiological development of wounds exhibiting delayed healing; nevertheless, the molecular regulatory networks governing this process in DFU pathogenesis remain incompletely elucidated DFU-related transcr...
Drosophila melanogaster provides a model system to examine how environmental stress interacts with sex to induce changes in brain function and behavio...
Gaining structural insights into the interactions between antibodies and their corresponding antigens is essential for understanding immune recognitio...
Integrative omics analyses enhance our understanding of disease mechanisms and biomarkers by investigating relationships among traits, omics measureme...
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome editing capabilities. However, generating d...
Craniofacial malformation (CFM) is a congenital defect encompassing a wide range of phenotypic presentations and is largely driven by genetics. Despit...
EGFR amplification occurs in approximately 40-50% of glioblastoma (GBM) cases and is critical for treatment selection [1]. However, GBM tissue samples...
Assessing the degree and characteristics of consciousness is central to caring for patients with Disorders of Consciousness (DoC), yet current standar...
Microbiome beta diversity analysis relies on distance-based methods including PERMANOVA combined with fixed ecological distance metrics (Bray-Curtis, ...
Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD), yet the genetic and molecular pathways that disr...
Industrial enzyme engineering focuses on improvement of enzyme production yield, stability, catalytic activity, and substrate specificity, but often s...
This work introduces a novel and specialized dataset of high-resolution fluorescence microscopic images focused on astrocytic gap junctions, aiming to...
The expression of antibiotic-inactivating enzymes, such as Pseudomonas-derived cephalosporinase-3 (PDC-3), is a major mechanism of intrinsic resistanc...
Understanding how DNA sequence encodes biological function remains a fundamental challenge in biology. Flowering plants (angiosperms), the dominant te...
Negative selection in the thymus limits autoimmunity by eliminating T cells that react strongly to self. Individual T cells, however, are only exposed...
Over 100 genes have been implicated in congenital heart disease (CHD), yet the genetic basis for >50% of CHD remains unexplained. A key challenge is t...
Languages provide social-category markers that tag people as one or another social group. How does the brain sort words into different language catego...
AlphaFold2 significantly improved the prediction of protein complex structures. However, its accuracy is lower for interactions without coevolutionary...
Genome-wide association studies (GWAS) have uncovered numerous variants linked to complex traits, yet power remains limited by the large multiple test...