COVID-19

Artificial Intelligence-Powered Simulation for Telehealth Communication Training: Bridging Traditional Simulation and Artificial Intelligence.

INTRODUCTION: Traditional simulation-based communication training remains resource-intensive and difficult to scale. While artificial intelligence (AI), particularly large language models, offers promising solutions for health care education, no blueprint exists for integrating AI-powered simulation training within operational quality improvement (QI) frameworks. This paper presents a 5-phase meth...

HLABrew for Human Leukocyte Antigen Class I-Presented Epitope Recognition and Mimotope Discovery.

Accurate identification of human leukocyte antigen (HLA) class I-presented epitopes is essential for developing personalized vaccines and immunotherapies. Here, we present HLABrew, a unified deep learning framework for HLA class I epitope prediction and allele-specific mimotope design. By integrating the Transformer, variational autoencoder, and dual cross-attention, HLABrew achieves state-of-the-...

A dynamic light image enhancement algorithm using generative adversarial network for group activity recognition.

Video-based or image-based human activity recognition (HAR) via machine learning algorithms helps track, detect, and categorize users' daily activitie...

Radiomics for predicting microsatellite instability-high status in colorectal cancer: a systematic review and meta-analysis.

OBJECTIVE: Microsatellite instability (MSI) has emerged as a key predictive biomarker for chemotherapy and immunotherapy response, and as a prognostic...

Fine-Tuning and Benchmarking Transformer Models for Multiclass Classification of Clinical Research Papers: Retrospective Modeling Study.

BACKGROUND: The exponential growth of digital information has led to an unprecedented expansion in the volume of unstructured text data. Efficient cla...

Recurrent Processing Dynamics in Occluded Object Recognition Revealed by Electroencephalography and Deep Neural Networks.

The human visual system excels at recognizing occluded objects, yet the temporal dynamics of recurrent processing in this task remain unclear. Using h...

Radiomics-based outcome prediction for irinotecan-TACE in colorectal liver metastases: advanced analysis from the prospective CIREL trial.

OBJECTIVES: Transarterial chemoembolization (TACE) is a promising locoregional therapy for unresectable colorectal liver metastases, but patient selec...

Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.

Most genetic variants in the human genome reside in non-coding regions, where they can perturb regulatory element activity to influence gene expressio...

Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.

We present a wavefront coding (WFC) based decoupled illumination-detection light sheet fluorescence microscopy (DID-LSFM) system that integrates machi...

Radiologist-AI Collaboration for Ischemia Diagnosis in Small-Bowel Obstruction: Multicentric Development and External Validation of a Multimodal Deep Learning Model.

This study aims to develop and externally validate a multimodal AI model for detecting ischemia complicating small-bowel obstruction (SBO). We combine...

Therapeutic targeting of Respiratory Syncytial Virus: Current pharmacological options and future directions in antiviral development.

Respiratory syncytial virus (RSV) remains a major cause of severe acute respiratory infections across the life course, particularly in infants, older ...

Serpinh1 promotes fracture healing by enhancing osteogenesis via activation of the Wnt/β-catenin signaling pathway.

BACKGROUND: The process of fracture healing encompasses tightly regulated cellular and molecular interactions. However, the precise regulatory mechani...

The Role of Molecular Testing in Head and Neck Squamous Cell Carcinoma of Unknown Primary.

Squamous cell carcinomas of unknown primary (SCCUP), accounting for approximately 5% of head and neck malignancies, present significant clinical chall...

Markerless gait analysis for children and adolescents with juvenile idiopathic arthritis using a machine learning pipeline.

BACKGROUND: Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. Whi...

Circulating miR-10b-5p as a Candidate Biomarker of Atrial Fibrillation Recurrence After Catheter Ablation: A Two-Phase Translational Study.

BACKGROUND: The identification of reliable biomarkers for atrial fibrillation (AF) recurrence post-catheter ablation remains a clinical challenge. Thi...

Urine-Based Noninvasive Detection of Prostate Cancer Using Human Olfactory Receptor-Embedded Nanodiscs.

The diagnosis of prostate cancer (PCa) is limited by the low specificity of prostate-specific antigen (PSA) testing, which contributes to overdiagnosi...

Role of Ambler Position 104 in Defining Substrate Specificity in the KPC Family of β-Lactamases.

Carbapenem-resistant Gram-negative bacteria pose a critical clinical challenge, largely due to the dissemination of class A Klebsiella pneumoniae carb...

Inference of germinal center evolutionary dynamics via simulation-based deep learning.

B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary proces...

OCTN1 variants shape innate immunity and predict individual response to anti-TNFα in ulcerative colitis patients: An exploratory study.

BACKGROUND: Ulcerative colitis (UC) exhibits substantial heterogeneity in inflammatory pathways and therapeutic response. The organic cation transport...

Panoramic Insights: Predicting Age and Gender from Dental X-Rays Using Deep Learning Models.

Age and gender estimation are crucial in forensic odontology for identification and legal purposes. Conventional methods utilizing manual interpretati...