COVID-19

Prediction of COVID-19 hospitalisation, ICU admission or death following ChAdOx1 vaccination using artificial intelligence: A clinical predictive model from the English RAVEN study.

OBJECTIVES: This study identifies predictors of severe COVID-19 following completion of two-dose primary series of the AZD1222 COVID-19 vaccine, employing eXtreme Gradient Boosting (XGBoost) and Shapely additive explanations (SHAP), as an explainable artificial intelligence (AI) approach. METHOD: A retrospective cohort study using linked primary care data from the Oxford-Royal College of General P...

NPHS2 Revisited Through 208 Cases and Podocin Complex Modeling.

INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Biallelic variants in NPHS2, encoding podocin, are the most common monogenic etiology. Podocin homo-oligomerizes to a critical slit diaphragm complex. NPHS2 genotype-phenotype relationships and podocin's assembly architecture remain incompletely defined...

Dual-Parallel Artificial Intelligence Framework for Breast Cancer Grading via High-Intensity Ultrasound and Biomarkers.

BACKGROUND: Accurate and noninvasive breast cancer grading and therapy monitoring remain critical challenges in oncology. Traditional methods often re...

HD-sEMG-Based Control Using Neck Muscles and Shallow Neural Networks: Assessing Performance in Rehabilitation-Oriented Tasks.

This paper investigated the suitability of the integrated Recursive Rehabilitation Control Network (RRC-Net)/ High-Density Electrode Array (HDE-Array)...

Evaluation of artificial intelligence identified ipratropium bromide for the treatment of coronavirus disease 2019.

Scaling genomic reanalysis to unlock diagnoses and transform rare disease care.

Genomic reanalysis can identify causative variants for rare diseases as patient phenotypes evolve and gene-disease knowledge expands. Despite its diag...

A deep neural network model of audiovisual speech recognition reports the McGurk effect.

In the McGurk effect, perception of an auditory syllable changes dramatically when it is paired with an incongruent visual syllable, countering our in...

Human Brain High-Resolution Diffusion MRI With Optimized, Slice-By-Slice, Zeroth and First Order B 0 $$ {B}_0 $$ Shimming in Head-Only High-Gradient MRI Systems.

PURPOSE: To propose a brain tissue-selective, optimized slice-by-slice B 0 $$ {B}_0 $$ shimming for high-resolution brain diffusion MRI. METHODS...

An odyssey of monoclonal gammopathies: focusing on precursors and the progression from MGUS and SMM to multiple Myeloma, with a brief overview of novel therapeutic strategies.

Monoclonal gammopathies span a continuum from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to overt...

Longitudinal brain-age predictions comprising long-duration spaceflight missions.

Our study investigates the effects of long-duration spaceflight on brain aging in spacefarers using structural MRI and machine learning models. Pre-, ...

Identification of molecular diagnostic markers and potential therapeutic drugs for Sjögren's syndrome.

Sjögren's Syndrome (SS) is a long-term autoimmune disorder marked by damage to exocrine glands and irregularities in the immune system. Currently, the...

A framework for unveiling multi-pathway mechanisms of soil heavy metal pollution: Evidence from five major urban agglomerations in China.

Urban agglomeration (UA) development exacerbates heavy metal contamination in farmland soils. Spatial patterns and region-specific drivers of this pol...

Analysing DCE-MRI scans using hybrid techniques for early detection of prostate cancer based on fusion features of handcrafted and deep learning features.

Prostate cancer is among the most diagnosed malignancies in men worldwide and a leading cause of cancer-related mortality. Early and accurate diagnosi...

Direct Integration of Ionic Liquid Gel Sensors onto Microfibrous Face Mask Substrates for Wearable Respiratory Health Monitoring.

Mask-integrated respiratory sensors are promising for noninvasive monitoring of respiratory health outside of clinical settings, for example, to suppo...

Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database.

PURPOSE: Germline pathogenic variants (GPV) are frequently identified as secondary findings in cancer gene panel testing. Due to limited data on germl...

Ferroptosis-Related Signature Genes and Immune Landscape in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

UNLABELLED: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by heightened inflammation and immune dysregulation,...

Advances and challenges in the application of metagenomic sequencing for the diagnosis and treatment of infectious diseases: from pathogen spectrum identification to personalized antimicrobial strategies.

Infectious diseases remain a major global public health concern, demanding rapid and accurate identification of pathogens. Although conventional diagn...

Exploring estrogen synthesis and metabolism related markers and immune dynamics in osteoporosis-insights from single-cell RNA sequencing and Mendelian randomization.

BACKGROUND: Osteoporosis (OP) is characterized by decreased bone mineral density and an increased fracture risk, often due to declining sex hormone le...

Advancements and challenges in CAR-NK cell therapy for cancer treatment.

Chimeric antigen receptor natural killer (CAR-NK) cell therapy is an emerging cancer treatment offering advantages over CAR-T therapy, including reduc...

Evaluating dual-path temporal fusion strategies for multi-modal hand gesture recognition under limb-position variability.

OBJECTIVE: Wearable biosignal-based hand gesture recognition (HGR) is a key enabling technology for prosthetic hand control, but its reliability i...