COVID-19

Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

PURPOSE: This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC), and further evaluate the performance of the model in different specific subgroups (N2 stage and anti-PD-1/PD-L1).

Mpox diagnosis at POC.

The increasing number of Monkeypox (Mpox) cases in non-endemic countries resulted in the WHO declaring a public health emergency of international concern. Accurate and timely diagnosis of Mpox has a critical role in containing the spread of infection. Diagnosis currently relies on PCR, which requires trained personnel and complex laboratory infrastructure. Thus, the development of point-of-care (P...

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR).

(Quantitative) structure-activity relationships ((Q)SARs) are widely used in chemical safety assessment to predict toxicological effects. Many thousan...

Integrating next-generation sequencing and artificial intelligence for the identification and validation of pathogenic variants in colorectal cancer.

BACKGROUND: Colorectal cancer (CRC) is recognized as a multifactorial disease, where both genetic and environmental factors play critical roles in its...

Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations....

VADEr: Vision Transformer-Inspired Framework for Polygenic Risk Reveals Underlying Genetic Heterogeneity in Prostate Cancer.

Polygenic risk scores (PRSs) serve as quantitative metrics of genetic liability for various conditions. Traditionally calculated as an effect size wei...

Dual-stream interactive networks with pearson-mask awareness for multivariate time series forecasting.

Multivariate time series forecasting (MTSF) aims to predict time series data containing multiple variates, which requires the consideration of both in...

ConsensuSV-ONT - A modern method for accurate structural variant calling.

Improvements in sequencing technology make the development of new tools for detection of structural variance more and more common. However, since the ...

Comparison of mask R-CNN and YOLOv8-seg for improved monitoring of the PCB surface during laser cleaning.

Potting compounds and coatings protect electronic components in harsh environments, requiring careful removal for recycling or repair. This study intr...

Aberrant formation of the neutrophil extracellular trap and the expression of the PLEKHA1 in systemic lupus erythematosus and ulcerative colitis.

Systemic lupus erythematosus (SLE) and ulcerative colitis (UC) are both chronic autoimmune diseases with unclear shared mechanisms, largely due to lim...

Upper-Body Strength and Range of Motion Are Associated With Sprint-Paddling Force and Performance in Competitive Female and Male Surfers.

Gosney, S, Parsonage, J, Worsey, M, Keogh, J, MacDonald, L, Denny, A, and Minahan, C. Upper-body strength and range of motion are associated with spri...

The neuronal chaperone proSAAS is highly expressed in the retina.

The many layers of the neuroretina contain a complex, interconnected network of specialized neurons that both process visual stimuli and conduct proce...

Development and evaluation of a direct disk diffusion, rapid antimicrobial susceptibility testing method from blood culture positive for Gram-negative bacilli using rapid molecular testing and microbiology laboratory automation.

Rapid antimicrobial susceptibility testing (RAST) using disk diffusion (DD) from positive blood cultures (BC) can aid initiation of effective antimicr...

Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments.

Type 2 diabetes mellitus (T2DM) and Major depressive disorder (MDD) act as risk factors for each other, and the comorbidity of both significantly incr...

Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines.

Vaccination remains a critical tool in preventing infectious diseases, yet its effectiveness is undermined by under-immunization, particularly for vac...

3D-ΔΔG: A Dual-Channel Prediction Model for Protein-Protein Binding Affinity Changes Following Mutation Based on Protein 3D Structures.

Protein-protein interactions are crucial for cellular regulation, antigen-antibody interactions, and other vital processes within living organisms. Ho...

Quantifying Sleep Quality Through Delta-Beta Coupling Across Sleep and Wakefulness.

Modern lifestyles contribute to insufficient sleep, impairing cognitive function and weakening the immune system. Sleep quality (SQ) is vital for phys...

Multiplex PCR-Liquid Chromatography High-Resolution Tandem Mass Spectrometry for Simultaneous Detection of Multiple Transgenes in Equine Plasma.

The development of gene therapy techniques introduces a potential risk of gene doping, which threatens the integrity of sport. In response to this cha...

Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study.

BACKGROUND: The efficacy of Laryngeal Mask Airway (LMA) epinephrine during neonatal resuscitation has not been studied. We hypothesize that LMA epinep...

A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer ...