Latest AI and machine learning research in cystic fibrosis for healthcare professionals.
Cystic fibrosis (CF) alters gut physiology, yet its impact on microbial communities across colonic regions (ascending, transverse, descending colon) and microhabitats (lumen, mucosa) remains incompletely understood. Here, we applied culturomics to characterize gut microbiota in 32 individuals (22 nonCF, 10 CF). Persons with CF (pwCF) exhibited significantly higher viable bacterial loads than nonCF...
Cystic fibrosis-related diabetes (CFRD) affects up to 60% of adults with CF and contributes to poorer clinical outcomes, including accelerated lung decline and increased mortality. CFRD is often diagnosed late, with limited mechanistic insight and few tools for early detection. We profiled serum-derived exosomes from 186 individuals, 173 with CF, across two independent cohorts (Australia and Denma...
Elexacaftor, tezacaftor, and ivacaftor (ETI) in triple combination improves pulmonary health for people with cystic fibrosis (PwCF). However, its imp...