Dementia

Comparative analysis of unsupervised clustering techniques using validation metrics: Study on cognitive features from the Canadian Longitudinal Study on Aging (CLSA)

Purpose: The primary goal of this study is to explore the application of evaluation metrics to different clustering algorithms using the data provided from the Canadian Longitudinal Study (CLSA), focusing on cognitive features. The objective of our work is to discover potential clinically relevant clusters that contribute to the development of dementia over time-based on cognitive changes. Metho...

Unlocking Neural Transparency: Jacobian Maps for Explainable AI in Alzheimer's Detection

Alzheimer's disease (AD) leads to progressive cognitive decline, making early detection crucial for effective intervention. While deep learning models have shown high accuracy in AD diagnosis, their lack of interpretability limits clinical trust and adoption. This paper introduces a novel pre-model approach leveraging Jacobian Maps (JMs) within a multi-modal framework to enhance explainability a...

AD-GPT: Large Language Models in Alzheimer's Disease

Large language models (LLMs) have emerged as powerful tools for medical information retrieval, yet their accuracy and depth remain limited in specia...

MENA: Multimodal Epistemic Network Analysis for Visualizing Competencies and Emotions

The need to improve geriatric care quality presents a challenge that requires insights from stakeholders. While simulated trainings can boost compet...

Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health.

Previous research has established type 2 diabetes mellitus as a significant risk factor for various disorders, adversely impacting human health. While...

Flexible and Explainable Graph Analysis for EEG-based Alzheimer's Disease Classification

Alzheimer's Disease is a progressive neurological disorder that is one of the most common forms of dementia. It leads to a decline in memory, reason...

Accelerating Causal Network Discovery of Alzheimer Disease Biomarkers via Scientific Literature-based Retrieval Augmented Generation

The causal relationships between biomarkers are essential for disease diagnosis and medical treatment planning. One notable application is Alzheimer...

GKAN: Explainable Diagnosis of Alzheimer's Disease Using Graph Neural Network with Kolmogorov-Arnold Networks

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that poses significant diagnostic challenges due to its complex etiology. Graph...

Evaluating Traditional, Deep Learning and Subfield Methods for Automatically Segmenting the Hippocampus From MRI.

Given the relationship between hippocampal atrophy and cognitive impairment in various pathological conditions, hippocampus segmentation from MRI is a...

Dynamic and Static Structure-Function Coupling With Machine Learning for the Early Detection of Alzheimer's Disease.

The progression of Alzheimer's disease (AD) involves complex changes in brain structure and function that are driven by their interaction, making stru...

Improving Diseases Predictions Utilizing External Bio-Banks

Machine learning has been successfully used in critical domains, such as medicine. However, extracting meaningful insights from biomedical data is o...

"Is There Anything Else?'': Examining Administrator Influence on Linguistic Features from the Cookie Theft Picture Description Cognitive Test

Alzheimer's Disease (AD) dementia is a progressive neurodegenerative disease that negatively impacts patients' cognitive ability. Previous studies h...

Early Prediction of Alzheimer's and Related Dementias: A Machine Learning Approach Utilizing Social Determinants of Health Data

Alzheimer's disease and related dementias (AD/ADRD) represent a growing healthcare crisis affecting over 6 million Americans. While genetic factors ...

PHGNN: A Novel Prompted Hypergraph Neural Network to Diagnose Alzheimer's Disease

The accurate diagnosis of Alzheimer's disease (AD) and prognosis of mild cognitive impairment (MCI) conversion are crucial for early intervention. H...

Alzheimer's Disease Classification Using Retinal OCT: TransnetOCT and Swin Transformer Models

Retinal optical coherence tomography (OCT) images are the biomarkers for neurodegenerative diseases, which are rising in prevalence. Early detection...

OPTIMUS: Predicting Multivariate Outcomes in Alzheimer's Disease Using Multi-modal Data amidst Missing Values

Alzheimer's disease, a neurodegenerative disorder, is associated with neural, genetic, and proteomic factors while affecting multiple cognitive and ...

Enhancing Alzheimer's Diagnosis: Leveraging Anatomical Landmarks in Graph Convolutional Neural Networks on Tetrahedral Meshes

Alzheimer's disease (AD) is a major neurodegenerative condition that affects millions around the world. As one of the main biomarkers in the AD diag...

BrainNet-MoE: Brain-Inspired Mixture-of-Experts Learning for Neurological Disease Identification

The Lewy body dementia (LBD) is the second most common neurodegenerative dementia after Alzheimer's disease (AD). Early differentiation between AD a...

Federated Learning for Predicting Mild Cognitive Impairment to Dementia Conversion

Dementia is a progressive condition that impairs an individual's cognitive health and daily functioning, with mild cognitive impairment (MCI) often ...

Quantum-Inspired Privacy-Preserving Federated Learning Framework for Secure Dementia Classification

Dementia, a neurological disorder impacting millions globally, presents significant challenges in diagnosis and patient care. With the rise of priva...