Neurology

Dementia

Latest AI and machine learning research in dementia for healthcare professionals.

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A Systematic Fairness Evaluation of Racial Bias in Alzheimer’s Disease Diagnosis Using Machine Learning Models

Alzheimer’s disease (AD) is a major global health concern, expected to affect 12.7 million Americans...

Cooperative multi-view integration with Scalable and Interpretable Model Explainer

Single-omics approaches often provide a limited perspective on complex biological systems, whereas m...

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease

Alterations in metabolism, stress response, sleep, circadian rhythms, and neuroendocrine processes a...

MRI-based classifier to identify close-to-onset cases in C9orf72 genetic frontotemporal dementia

Predicting symptom onset in genetic frontotemporal dementia (FTD) is crucial for advancing targeted ...

Neural Underpinnings of Olfactory Dysfunction across Parkinson’s and Alzheimer’s Spectra

Olfactory dysfunction is a frequent yet understudied feature of neurodegenerative spectrum disorders...

Bridging Language Markers and Pathology: Correlations Between Digital Speech Measures and Surrogate CSF Biomarkers in Alzheimer’s Disease

Digital language markers show promise in detecting early cognitive impairment related to Alzheimer’s...

Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice

Hyaluronan and proteoglycan link protein 2 (HAPLN2) / Brain link protein-1 (Bral1) is important for ...

Protein Compositional Ratio Representation (PCRR) Systematically Improves Human Disease Prediction

Plasma proteomics captures a functional snapshot of human physiology; yet, most machine learning mod...

BrainBridge Characterizes Key Factors affecting Alzheimer’s Disease and Associated Phenotypes

Single-cell RNA sequencing (scRNA-seq) has significantly advanced our understanding of Alzheimer’s d...

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation

Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD)...

Temporal Dynamics of High-Frequency Oscillations in Alzheimer’s Disease: A Longitudinal Study in hAPP-J20 Mice

Alzheimer’s disease (AD) is characterized by progressive cognitive decline and increased seizure sus...

Predicting Dementia in People with Parkinson’s Disease

Parkinson’s disease (PD) exhibits a variety of symptoms, with approximately 25% of patients experien...

The genetics of TDP43-Type-C neurodegeneration: a whole genome sequencing study

Frontotemporal lobar degeneration-TDP Type C (TDP-C) is a unique neurodegenerative disease that star...

VR-based Gamma Sensory Stimulation: A feasibility study

Alzheimer’s disease (AD) presents a critical global health challenge, with current therapies offerin...

Generalizable Prediction of Alzheimer Disease Pathologies with a Scalable Annotation Tool and an High-Accuracy Model

Characterizing the cardinal neuropathologies in Alzheimer disease (AD) can be laborious, time consum...

Explainable artificial intelligence for neuroimaging-based dementia diagnosis and prognosis

INTRODUCTION: Artificial intelligence and neuroimaging enable accurate dementia prediction, but ‘bla...

Short-Term Mortality After Opioid Initiation Among Opioid-Naïve and Non-Naïve Patients with Dementia: A Retrospective Cohort Study

Despite the ongoing opioid epidemic, the mortality risk of opioid initiation in patients with dement...

Transcriptomic analyses of human brains with Alzheimer’s disease identified dysregulated epilepsy-causing genes

Alzheimer’s Disease (AD) patients at multiple stages of disease progression have a high prevalence o...

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