Neurology

Dementia

Latest AI and machine learning research in dementia for healthcare professionals.

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Retinal OCTA Phenotyping with LLM Reporting for Alzheimer's Disease

Early identification of Alzheimer's disease (AD) remains challenging because established assessment ...

A Generalizable Feature Extractor for Alzheimer's-Related Brain MRI Tasks

When there is not enough labeled data to properly train deep learning models, transfer learning can ...

Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimers disease

The apolipoprotein E {varepsilon}4 (APOE {varepsilon}4) allele is the strongest genetic risk factor ...

Evaluating Clinical Foundation Models for Early Alzheimer's Disease and Related Dementia Prediction from Longitudinal EHRs

Early identification of Alzheimer's disease and related dementias (ADRD) remains challenging despite...

The Blind Spot in 2D Infants' Pose Estimation:Robust Learning from Noisy Annotations

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely...

A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid

Background: The Centiloid (CL) scale standardizes global amyloid PET quantification and is widely us...

GraM-Diff: A Unified Graph-Mamba Diffusion Framework for EEG-Based Alzheimer's Disease Data Generation and Diagnosis

Electroencephalography (EEG) is a promising, non-invasive, and cost-effective modality for Alzheimer...

Under-Mattress Temporal Sensing for Next-Day Agitation Risk Scoring in Dementia Wards

Agitation fluctuates over short time horizons in people living with dementia, yet continuous physiol...

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

Biological heterogeneity in Alzheimer's Disease (AD) poses a critical diagnostic challenge, particul...

Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum

Neuropsychiatric symptoms (NPS) are increasingly recognized as critical components of the disease pr...

Integrating cognitive, linguistic and acoustic features to identify individuals with cognitive impairment: a proof-of-concept study

Early identification of cognitive impairment remains challenging in settings where comprehensive cog...

Behind the [MASK]: Disentangling Representation and Faithfulness in DAPF-Based Dementia Detection

Spoken-language analysis via prompt-based domain-adaptive models is a promising direction for low-re...

Spoken Recall Reveals Lexical and Mnemonic Function Differences in Temporal Lobe Epilepsy Patients

Background and Objectives: Word-finding difficulty is common in healthy aging and in neurologic diso...

Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion

In Alzheimer's disease (AD), misfolded proteins emerge across the entire brain in structured, yet no...

Reliability and disease sensitivity are dissociable properties of EEG foundation-model representations

Abstract EEG foundation models (EEG-FMs) are evaluated almost entirely on disease-discrimination acc...

Predicting Subjective Cognitive Decline on Future BRFSS Survey Years: An Open Multi-Language Machine Learning Benchmark

Background and Objectives: Subjective cognitive decline (SCD), self-reported worsening confusion or ...

Longitudinal Bayesian Learning of Continuous Disease Position across the Alzheimer's Disease Continuum

Alzheimer's disease (AD) progresses as a continuous biological process, whereas most existing neuroi...

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