Neurology

Dementia

Latest AI and machine learning research in dementia for healthcare professionals.

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When does more data help? Spectral Geometry and Scaling Laws in MRI Transformers

Scaling laws describe how model performance improves as the amount of training data increases, and r...

Death in People with Down syndrome: Mortality statistics and novel predictors in US Medicaid and Medicare enrolled adults.

People with Down syndrome have higher age-specific mortality rates compared to the general populatio...

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What Do Persistent Misclassifications Tell Us About Alzheimer's Disease Detection using Structural MRI?

Deep learning classifiers applied to structural MRI (sMRI) have achieved high performance in detecti...

Calibrated Alzheimer's Conversion Risk in Mild Cognitive Impairment: Persistent Homology of Clinical Trajectories with Conformal Guarantees

Background. Predicting conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) i...

Differentiable Logic Gate Networks for Low-Latency EEG Classification on Edge Devices

Real-time EEG classification on edge devices is bottlenecked by the floating-point arithmetic of con...

Sex Differences in the Alzheimer's Brain Age Gap: APOE ε4 Plays a Major Role

INTRODUCTION: Brain age gap (BAG) is the difference between a person's chronological age and the age...

Parameter-efficient Prompt Tuning of Vision Foundation Model With Adaptive Focal Loss for Interpretable MCI Screening

Mild Cognitive Impairment is a critical early stage of cognitive decline that frequently precedes Al...

A Multimodal Benchmark for Evaluating Cause-of-Death Inference Using Child Health and Mortality Data

Accurately attributing causes of death is vital for global health, yet fewer than 5% of deaths in re...

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The Swiss Integrated Care (INCA) Study: Description of a Novel Prospective Cohort of Patients and Caregivers in Reimbursed Informal Care

Methods INCA is a prospective, single-center cohort study with nationwide recruitment. Participation...

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The Prognostic Value of Genetic Architectures in Cognitive Decline

Background & Methods: The multifaceted physical nature of heritable cognitive impairment in dementia...

Explainable Longitudinal Machine Learning for Dementia Progression Using Cognitive and MRI Biomarkers

Dementia is a progressive neurological condition characterized by cognitive decline and structural b...

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Explainable Machine Learning Models for Alzheimer's Diagnosis Using Routine and Low-Cost Clinical Data

Emerging as a significant global health challenge, Alzheimer's Disease (AD) is a progressive neurode...

The Patients' Voice in Clostridioides difficile Infection: Large Language Model-Assisted Thematic Analysis of Patient Testimonials

Background. Clostridioides difficile infection (CDI) imposes a burden that extends well beyond the g...

Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US Veterans

Background: Hypertension is a modifiable risk factor for dementia, yet the comparative effectiveness...

Retina-derived Quantitative Biomarkers of Brain Health

Accurate and scalable assessment of quantitative neuroimaging biomarkers, such as white matter hyper...

Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

Background: Lewy body diseases (LBD) collectively share alpha-synuclein Lewy pathology, yet present ...

When Color Adds Nothing: A Causal Audit of Channel Triplication in Alzheimer's MRI Classification

Medical imaging pipelines routinely copy single-channel grayscale data into three identical RGB chan...

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