Dementia

Predicting Early Stages Of Alzheimer's Disease And Identifying Key Biomarkers Using Deep Artificial Neural Network And Ensemble Of Machine Learning Methodologies

Alzheimers disease (AD) is a brain disorder that develops slowly and mainly affects memory, thinking, language, and daily activities. It is one of the most common causes of dementia and creates many difficulties for patients as well as their families. In the early stage, the symptoms are often mild and may look like normal ageing. For this reason, many people are diagnosed late, when the disease h...

NeuroBridge: Bridging Multi-Task MRI Knowledge for Neurodegenerative Disease Diagnosis

INTRODUCTION: Accurate MRI-based identification of Alzheimer's disease (AD), mild cognitive impairment (MCI), and related dementias remains challenging because disease-related structural changes are often subtle and heterogeneous. We developed NeuroBridge, a clinically guided multi-task MRI framework for neurodegenerative disease diagnosis. METHODS: NeuroBridge integrates large-scale self-supervis...

Attitudes of People Living with Dementia and their Carers towards the use of Generative Artificial Intelligence to inform Structured Medication Reviews

Background: Polypharmacy is common in people living with dementia (PLwD) and associated with adverse outcomes. Although Structured Medication Reviews ...

Causally measuring aging and rejuvenation through transcriptomic damage

Aging is caused, fully in large part, by the progressive accumulation of damage, yet quantifying age-related damage across tissues and conditions rema...

ENC-ODE: Event-level Neurodegenerative Modeling in Continuous Time with Neural ODEs

Accurately predicting the temporal evolution of clinical biomarkers is crucial for the early diagnosis and management of neurodegenerative diseases su...

A Multidomain Model for Dementia Classification using Harmonized LASI and LASI-DAD Data

ABSTRACT Dementia classification in heterogeneous populations is complicated by the influence of education, language, socioeconomic position and healt...

Neural operator-based digital twins for modeling amyloid-$β$ and tau propagation and treatment optimization in Alzheimer's disease

Accurately predicting the spatiotemporal evolution of amyloid-$β$ and tau proteins at the individual level is critical for improving the diagnosis and...

Machine learning-based modeling to predict inhibitors for targets of Alzheimer's Disease

Alzheimer's Disease is a chronic neurodegenerative disorder projected to affect 115 million people by 2050, driven by mechanisms like the cholinergic ...

Uncertainty-Aware Longitudinal Forecasting of Alzheimer's Disease Progression Using Deep Learning

Longitudinal modelling of Alzheimer's disease progression is clinically useful only if it can describe not just the most likely next diagnosis, but ho...

MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer's Disease Neuroimaging Initiative

Background: Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti-amyloid therapy safety due to ARIA-H risk. We developed MCH-Guard...

Alzheimer's Disease Diagnosis using a Multimodal Approach with 3D MRI and PET

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide. Early diagnosis plays an important part...

Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Masks

Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation,...

OmicOS: A Comprehensive Omics Ecosystem Infrastructure and Agent System for the AI Era

Biology has accumulated a vast ecosystem of omics methods, but much of this ecosystem remains built for expert humans rather than scientific agents. M...

A Quantitative Analysis of Multimodal Biomarkers in Alzheimer's Disease

Despite increasing adoption of multimodal approaches in Alzheimer's Disease (AD) research -- aimed at integrating molecular, structural, clinical, and...

VarEx: A Large Language Model Pipeline for Automated Extraction of Exposures, Outcomes, and Covariates from Epidemiologic Studies

Objective: Observational studies are essential for investigating risk factors for Alzheimer's disease and related dementias (ADRD), but inconsistent r...

Bayesian Networks with Latent Time Embedding for Stage-Aware Causal Modeling of Alzheimer's Disease Progression

Alzheimer's disease (AD) progression is often described through the amyloid-tau-neurodegeneration, or AT(N), cascade. However, most longitudinal model...

Hybrid Classical-Quantum (HCQ) Alzheimer's Classification via Supervised $β$-VAE and Quantum Kernels

This paper presents a two-stage Hybrid Classical-Quantum (HCQ) pipeline for binary Alzheimer's disease (AD) classification from 3D T1-weighted structu...

GMN4AD: Graph Matching Network for Alzheimer's Disease Diagnosis with Test-Time Domain Adaptation using Multi-centered Structure Magnetic Resonance Imaging

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that affects millions of older adults, with prevalence expected to rise significa...

End-to-End Machine Learning for Depressive State Classification via EEG and fNIRS

The escalating demand for mental healthcare, driven by rising societal stress, highlights the limitations of traditional psychiatric diagnostics. Conv...

Multimodal Ordinal Modeling of Alzheimer's Disease Severity Using Structural MRI and Clinical Data

Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical s...