Psychiatry

Depression

Latest AI and machine learning research in depression for healthcare professionals.

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Integration of network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of Psychotria rubra in depression treatment.

Depression is a chronic mental disorder with high disability and mortality rates, affecting approximately 95 million individuals in China alone. The limitations of current antidepressant therapies, including restricted efficacy, delayed onset, and significant adverse effects, have motivated the search for alternative treatments from traditional Chinese medicine. Psychotria rubra (PR), a widely dis...

Sep 2 2026 42684615

A Clinical AI-Based System (MoodMon) for Affective Disorders: Algorithm Development and Validation.

BACKGROUND: Psychiatry needs objective technological tools to address global staffing shortages, stigma, and other systemic challenges. An AI-based system for mood monitoring (MoodMon) was developed along with a mobile app for smartphones to detect changes in the mental state of individuals with major depressive disorder (MDD) and bipolar disorder (BD) based on acoustic features derived from speec...

Sep 2 2026 42684674
Emotionally engaged speech reveals acoustic markers of depression and suicide risk.

BACKGROUND: Major depressive disorder exists along a continuum, from health through remission to active depression. Differentiating these states remai...

Sep 2 2026 42686074
Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.

Marked interindividual heterogeneity in substance use disorder (SUD) impedes the identification of consistent neuroanatomical alterations, limiting th...

Sep 2 2026 42686998
Unsupervised Identification of Population Clusters With Distinct Low Back Pain Profiles.

BACKGROUND CONTEXT: Low back pain (LBP) is a leading cause of disability worldwide, yet population-level stratification of LBP risk remains limited. U...

Sep 1 2026 42679904
Digital and Biomarker-Based Monitoring for Schizophrenia-Treatment Adherence.

BACKGROUND: Nonadherence to antipsychotics affects nearly half of patients with schizophrenia, leading to rehospitalization, suicidality, and reduced ...

Sep 1 2026 42478867
Machine Learning Models for Predicting Pain, Fatigue, Depression, Anxiety, and Malnutrition in Cancer Patients: A Systematic Review and Meta-Analysis.

INTRODUCTION: Cancer-related symptoms including pain, fatigue, depression, anxiety, and malnutrition drive poor quality of life and adverse clinical o...

Sep 1 2026 42584044
Harmonising Depression and Anxiety Measures Across International Cohorts: A Framework Validated Using Measurement Invariance.

AIMS: Cross-national research on mental health trajectories requires harmonised measures that are valid and comparable. However, measurement scales of...

Sep 1 2026 42661415
Bioinformatics Analysis of the Diagnostic Value of Copper and Zinc Metabolism-Related Genes in Major Depressive Disorder: An In Silico Multi-Cohort Study.

This study aimed to identify copper and zinc metabolism-related genes as potential diagnostic biomarkers for major depressive disorder through an inte...

Aug 31 2026 42623125
Spatial synaptic pruning mechanism of NAC microglia in differential regulation of PTSD- and depression-like behaviors.

BACKGROUND AND AIMS: Post-traumatic stress disorder (PTSD) comorbid with depression is a prevalent, treatment-refractory clinical syndrome. Emerging e...

Aug 30 2026 42669315
MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews.

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only...

Aug 28 2026 42664926
Latent profiles of generative artificial intelligence use among Chinese college students: Associations with depression and anxiety.

BACKGROUND: While generative artificial intelligence (GenAI) has been rapidly adopted by college students, its relationship with mental health remains...

Aug 27 2026 42660392
Precision psychiatry in clinical practice: What is clinically actionable, what is promising, and what remains experimental?

Precision psychiatry seeks to improve individual-level prediction, treatment selection, monitoring, and prevention by integrating clinical, biological...

Aug 27 2026 42657684
Identification of suicidal ideation in major depressive disorder: A machine learning approach with multimodal digital features.

Current detection models for suicidal ideation (SI) among depressed patients have primarily relied on clinical and biological features. This study aim...

Aug 27 2026 42658794
Depression prediction and key factors: A comparative analysis of logistic regression and machine learning models.

OBJECTIVES: Factors associated with depression were explored in this study through logistic regression, and predictive performance was compared with v...

Aug 27 2026 42658859
MSPPGT: A Multi-Scale Pyramid Pooling-Based Graph Transformer Framework for Neuropsychiatric Disorder Diagnosis.

Graph Neural Networks (GNNs) model functional connectivity patterns between brain regions via neighborhood information aggregation. However, most GNN ...

Aug 26 2026 42647706
Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea.

AIMS: Epigenetic regulation of the oxytocin receptor gene (OXTR), particularly DNA methylation (DNAm), has been linked to insecure attachment, anxiety...

Aug 26 2026 42648552
Assessing the Utility of Social Determinants of Health Data in Suicide Prediction Models.

OBJECTIVE: This study seeks to explore the utility of social determinants of health (SDoH) variables in suicide prediction models. We aim to assess th...

Aug 25 2026 42639809
Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.

Adolescent major depressive disorder (MDD) is a heterogeneous disorder that complicates diagnosis and treatment. However, the mechanisms underlying th...

Aug 25 2026 42640475
Early-life inflammatory subgroups in youth with psychotic experiences: A semi-supervised machine learning approach.

AIMS: Psychotic experiences (PEs) are relatively common in youth and are associated with increased risk for later psychotic disorders. Although inflam...

Aug 25 2026 42641669
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