Devices and Vaccines

TEIP: A Compact, Open-Source Framework for Predicting Tumor Epitope Immunogenicity in Glioblastoma Using Deep Learning and Multi-Modal Biological Features

This work introduces a modular, open-source computational pipeline for glioblastoma (GBM) vaccine design that integrates omics-based OIP5 target discovery with a deep learning framework for epitope immunogenicity prediction. Building upon conventional affinity-based predictors such as NetMHCpan, our Tumor Epitope Immunogenicity Pipeline (TEIP) incorporates biological, structural, and transcriptomi...

A Computational Pipeline for Glioblastoma Vaccine Development: Integrating Novel Omics-Driven OIP5 Target Discovery to Create a Deep Learning-Based Immunogenicity Framework for Personalized Immunotherapy

This work introduces a modular, open-source computational pipeline for glioblastoma (GBM) vaccine design that integrates omics-based OIP5 target discovery with a deep learning framework for epitope immunogenicity prediction. Building upon conventional affinity-based predictors such as NetMHCpan, our Tumor Epitope Immunogenicity Pipeline (TEIP) incorporates biological, structural, and transcriptomi...

From minutes to bounds: A probabilistic UV-C control and a shape-only morphological fingerprint for postharvest Colletotrichum

Postharvest losses in high-value horticultural crops such as cacao and coffee are often driven by Colletotrichum spp. and other latent fruit pathogens...

De Novo Computational Design of VHH Nanobodies Against LGR5

VHH discovery traditionally relies on animal immunization or large-scale library screening, methods that are slow, costly, and often ineffective for c...

Large generative mRNA language foundation model for efficient coding sequence generation and design with mRNA-GPT

mRNA design plays a central role in synthetic biology, nucleic acid therapeutics, and vaccine development. Although large language models are applied ...

Ensemble-DeepSets: an interpretable deep learning framework for single-cell resolution profiling of immunological aging

Immunological aging (immunosenescence) drives increased susceptibility to infections and reduced vaccine efficacy in elderly populations. Current bulk...

Molecular Biointerface Characterisation for an Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS)

Implanted medical devices often fail due to foreign body reaction (FBR), a process still not fully understood. This work presents a new depth profilin...

VaxjoGNN: A Graph Neural Network for Ontology-Grounded Vaccine Adjuvant Recommendation

The selection of an effective adjuvant is a critical bottleneck in vaccine development, particularly for emerging diseases where experimental data is ...

Deep Learning–Based Early Detection of Major Adverse Cerebral Injuries in Cardiothoracic and Vascular Surgery

Despite advances in central nervous system (CNS)-protective anesthetic and surgical strategies, perioperative stroke remains a significant concern in ...

SYSTEMS AND NETWORK BIOLOGY ANALYSIS COMBINED WITH MACHINE LEARNING IDENTIFIES KEY IMMUNE RESPONSE PROFILES AND POTENTIAL CORRELATES OF PROTECTION FOR THE M72/AS01E TUBERCULOSIS VACCINE

Tuberculosis claims around 1.5 million lives annually. The M72/AS01E vaccine candidate is an innovative effort demonstrating a 50% reduction in the in...

Utilizing ChatGPT to select literature for meta-analysis shows workload reduction while maintaining a similar recall level as manual curation

Large language models (LLMs) like ChatGPT showed great potential in aiding medical research. A heavy workload in filtering records is needed during th...

Using large language models to understand the public discourse towards vaccination in Brazil between January 2013 and December 2019

Vaccination against infectious diseases prevents diseases, saves lives, and reduces healthcare costs. However, trust, accessibility, and public percep...

A Claims-Based Machine Learning Classifier of Modified Rankin Scale in Acute Ischemic Stroke

We developed a classifier to infer acute ischemic stroke (AIS) severity from Medicare claims using the Modified Rankin Scale (mRS) at discharge. The c...

Quantifying Device Type and Handedness Biases in a Remote Parkinson’s Disease AI-Powered Assessment

Early detection of Parkinson’s Disease (PD) can enable early access to care, improving patient outcomes. We investigate the use of machine learning to...

Foundation time series models for forecasting and policy evaluation in infectious disease epidemics

Epidemic forecasting and policy evaluation rely on mathematical models to predict infectious disease trends and assess the impact of public health pol...

Sentiment analysis of employees and COVID-19 vaccine hesitancy at workplace

Vaccination is a potent means to combat the spread of infectious disease epidemics or pandemics, such as the COVID-19 pandemic. However, getting suffi...

Integrated Explainable Ensemble Machine Learning Prediction of Injury Severity in Agricultural Accidents

Agricultural injuries remain a significant occupational hazard, causing substantial human and economic losses worldwide. This study investigates the p...

Diagnostic accuracy in detecting malignancy in suspicious skin lesions using Artificial Intelligence

Artificial Intelligence (AI) has demonstrated a high image processing capacity and improved diagnostic accuracy in dermatology. In this context, Compu...

Mining Social Media Data for Influenza Vaccine Effectiveness Using a Large Language Model and Chain-of-Thought Prompting

Influenza vaccine effectiveness (VE) estimation plays a critical role in public health decision-making by quantifying the real-world impact of vaccina...

Utilizing Machine Learning Models to Predict Acute Kidney Injury in Septic Patients from MIMIC-III Database

Sepsis is a severe condition that causes the body to respond incorrectly to an infection. This reaction can subsequently cause organ failure, a major ...