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Artificial Intelligence Across the Vaccine Clinical Trial Lifecycle: Evidence, Readiness, and Guardrails.

Artificial intelligence (AI) is increasingly being used to support clinical research, but its value in vaccine clinical trials requires careful evidence-based assessment. Vaccine trials pose distinctive challenges, including high safety expectations in healthy participants, evolving pathogen exposure and baseline immunity, incomplete correlates of protection, applicability of findings to intended-...

Jul 17 2026 42464875

Electrically Coded Retinomorphic Spectrophotodetector.

Accurate color sensing is essential for applications ranging from materials analysis to autonomous vision, yet compact systems that can classify color directly at the device level without bulky optics or computationally intensive post-processing remain limited. Here, a machine learning-free, self-powered retinomorphic pyro-photodetector is demonstrated for direct electrical wavelength encoding fro...

Jul 17 2026 42464893
Effectiveness of an AI-augmented teacher feedback model in improving medical students' clinical documentation skills: a retrospective cohort study.

BACKGROUND: Clinical documentation is central to evaluating medical students' clinical competence. However, traditional teacher feedback is often inef...

Jul 16 2026 42464292
AI-Simulated Patients for Training Shared Decision-Making: Feasibility Study in Medical Education.

BACKGROUND: Shared decision-making (SDM) is a key element of patient-centered care; however, opportunities for structured and scalable SDM training re...

Jul 16 2026 42464795
Using Artificial Intelligence to Identify Patterns and Predictors of Adverse Drug Reactions in Cardiovascular Patients: A Comprehensive Narrative Review.

Artificial intelligence (AI) has emerged as a transformative tool for improving the detection, prediction, and prevention of adverse drug reactions (A...

Jul 16 2026 42461503
AI for Causality Assessment in Pharmacovigilance: Protocol for a Scoping Review.

BACKGROUND: Pharmacovigilance aims to protect patient safety by identifying and managing adverse events associated with pharmaceuticals. Determining t...

Jul 16 2026 42462221
Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial.

BACKGROUND: Artificial intelligence (AI)-based computer-aided detection (CADe) systems improve adenoma detection in average-risk colorectal cancer scr...

Jul 16 2026 42462747
Artificial intelligence-based chatbots to enhance medication adherence among patients with non-communicable chronic diseases: Systematic review and meta-analysis.

Medication adherence remains a major public health challenge among patients with non-communicable diseases (NCDs) worldwide. Artificial intelligence (...

Jul 16 2026 42461826
A novel deep-learning approach for robust identification of plant diseases.

Rising temperatures and changing weather conditions are accelerating the spread of plant diseases and increasing the threat to global food security. R...

Jul 16 2026 42461837
Translating machine learning predictions into meaningful risk estimates to support clinical decisions: a post hoc analysis of chronic obstructive pulmonary disease adverse outcomes using unified auto clinical scores.

OBJECTIVE: The successful integration of Machine Learning (ML) models into clinical practice remains limited, as they often lack the standardized, qua...

Jul 15 2026 42454974
Artificial Intelligence-Generated Electronic Medical Record Summarization in Breast Surgical Oncology.

BACKGROUND: Reviewing pathology, imaging, and consultation documents in oncology can be time-consuming, particularly when records originate from exter...

Jul 15 2026 42455485
Beyond Geometric Deformation: High-Fidelity Orthodontic Profile Synthesis via ControlNet-Guided Generative AI.

OBJECTIVE: To develop and validate a clinically oriented, diffusion-based framework for orthodontic profile visualization that synthesizes photorealis...

Jul 15 2026 42457116
A scoping review of explainable artificial intelligence for medical multimodal data.

Multimodal Artificial Intelligence (AI) models-integrating diverse data such as imaging and clinical records-are advancing rapidly in healthcare, yet ...

Jul 15 2026 42457856
Augmenting Medical Judgment in Signal Confirmation: Design Considerations for an AI-Enabled Causality Assessment Framework.

The safety signal assessment process evaluates the potential causal association between a medicinal product and a specific adverse event by integratin...

Jul 15 2026 42458173
An AI-Assisted pictorial measure of children's dental anxiety during the initial child-dentist interaction.

BACKGROUND: The potential influence of the initial child-dentist interaction on dental anxiety (DA) in preschool children remains insufficiently under...

Jul 14 2026 42449269
Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix.

BACKGROUND: Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB...

Jul 14 2026 42446369
AI-Generated Microlearning for Plastic Surgery Residency: Single-Arm Pre-Post Feasibility Study.

BACKGROUND: Surgical residency training faces mounting pressure from expanding subspecialty knowledge requirements alongside compressed learning oppor...

Jul 14 2026 42447483
An Interactive Virtual Nephrologist to Engage Patients With Advanced CKD About Transplantation.

RATIONALE & OBJECTIVE: Despite advantages in survival and quality of life with kidney transplantation (KT) compared to other treatments for kidney fai...

Jul 14 2026 42448023
Machine learning-based prognosis and early death prediction in de novo stage IV breast cancer patients with bone metastasis: a SEER database and multicentre retrospective study.

Bone is the most common site of distant metastasis in breast cancer (BC), and the development of bone metastasis (BM) is associated with reduced survi...

Jul 14 2026 42448741
Tree-based machine learning models recover rule-based flare labels from virtual symptom diaries in pediatric Behçet's disease: an in silico proof-of-concept study.

Behçet's disease (BD) in childhood is characterised by recurrent inflammatory flares that can result in significant morbidity, most notably with ocula...

Jul 14 2026 42443634
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