Devices and Vaccines

Reconstruction of emergence profile using a digital mirroring technique in a custom biological definitive abutment and interim restoration in immediate implant placement in esthetic area: A clinical report with 4-year follow-up.

Immediate implant placement and interim restoration in the anterior maxilla remains challenging because of the high esthetic demands and the risk of soft-tissue recession. This clinical report describes a fully digital workflow integrating artificial intelligence (AI)-assisted data segmentation, a digital mirroring technique, and the computer-aided design and computer-aided manufacture (CAD-CAM) f...

NetMHCIIphosPan: A Machine Learning Tool for Predicting HLA Class II Antigen Presentation of Phosphorylated Peptides.

Phosphorylated peptides presented by human leukocyte antigen (HLA) class II molecules play pivotal roles in immune regulation, yet their characterization and prediction remain challenging due to data noise and limited HLA coverage. Here, we introduce NetMHCIIphosPan, a prediction method for HLA-II antigen presentation of phosphorylated peptides, developed using mass spectrometry (MS)-based immunop...

Automated Classification of Alveolar Bone Defects for Preoperative Augmentation Planning Using Deep Learning.

OBJECTIVES: Determining alveolar bone deficiencies prior to dental implant surgeries is critical for surgical planning. This study aimed to develop a ...

A hybrid dual-stream CNN framework with dynamic data augmentation and improved Manta Ray Foraging Optimization for robust glaucoma detection.

A progressive neurological condition, glaucoma is one of the main causes of irreversible blindness in the globe. Early detection is crucial to prevent...

Fractional-order differential model for knee implant recovery in smart health infrastructures.

Recovery from knee replacement surgery in conventional orthopaedic healthcare systems can be delayed due to high costs, pain, limited monitoring, and ...

Development and validation of the Oxford Attitudes to Artificial Intelligence in Medicine Scale.

OBJECTIVE: Public willingness to accept medical artificial intelligence (AI) tools affect the potential real-world impact of these evolving technologi...

The Assessment of Coronal Plane Lower-Limb Alignment on Pre- and Postoperative Long-Leg Radiographs Using Deep Learning.

INTRODUCTION: Coronal plane lower-limb alignment, defined by metrics including the hip-knee-ankle angle (HKAA), lateral distal femoral angle (LDFA), a...

Mechanobiological design strategy for additively manufacturable tibial ankle implant for enhanced biomechanical and osseointegration performance: A finite element and machine learning approach.

The leading cause of revision surgeries in ankle arthroplasty is aseptic loosening of the tibial implant, resulting from adverse bone remodelling and ...

Multimodal imaging in left main and bifurcation revascularization: contemporary evidence and comparative modalities review.

Left main (LM) and bifurcation coronary artery disease (CAD) are anatomically complex lesions which require detailed planning and precise execution fo...

Automatic sleep staging from CPAP airflow using a dual fusion multi-period convolutional neural network.

BACKGROUND: Continuous Positive Airway Pressure (CPAP) therapy is the standard treatment for obstructive sleep apnea-hypopnea syndrome, yet its use as...

mRNASyner: An Integrative Framework for Full-Length mRNA Sequence Optimization via Multimodule Synergistic Design.

Messenger RNA (mRNA) technology holds great promise in biomedicine; however, its therapeutic efficacy relies heavily on translation efficiency and the...

Speaking Patient's Language: Assessment of Readability and Fidelity of Artificial Intelligence-Optimized Consent Forms.

INTRODUCTION: Informed consent requires patients to fully comprehend the risks, benefits, and alternatives of an intervention. The American Medical As...

Evaluating the performance of large language models versus prosthodontic residents on the 2024 and 2025 National Prosthodontic Resident Examination.

STATEMENT OF PROBLEM: Recent advancements in large language models (LLMs) offer expanded reasoning, multimodal processing, and improved factual ground...

Programmable optical activation functions for KANs via feed-forward integrated microring resonators.

Activation functions are indispensable in optical neural networks (ONNs). However, existing solutions often require high optical power for nonlinearit...

Prompt engineering of large language models for paper screening in medical meta-analyses and systematic reviews: A prospective comparative study.

Interest in large language models (LLMs) as a tool for meta-analyses and systematic reviews (MA/SRs) is growing. We prospectively developed 515 unique...

Micro-CT Evaluation of Robot-Assisted Insertion of CI632 Implant in Human Cadaveric Temporal Bones.

OBJECTIVE: To evaluate the surgical accuracy and intracochlear positioning of robot-assisted insertion of slim modiolar cochlear implant electrode arr...

Initial Multicenter Evaluation of a Novel Anchoring Exchange Device: AI-based Quantitative Distal Tip-Motion Analysis.

PURPOSE: Exchange maneuvers during intracranial angioplasty and stent deployment can cause unintended distal tip motion, potentially leading to vessel...

Artificial intelligence-driven virtual reality eye-tracking for the objective measurement of MRD1 and MRD2 in blepharoptosis.

Accurate measurement of eyelid position is essential for diagnosis and surgical planning in blepharoptosis, but traditional manual assessment using pe...

AI-assisted phage formulation delivered via injectable hydrogels for localized control of implant-associated infections.

Bacteriophages are emerging as highly effective antimicrobials for the treatment of persistent bacterial infections, offering precision-targeted actio...

Deep learning magnetic resonance imaging algorithm for differentiating metastatic vertebral fractures.

BACKGROUND CONTEXT: Distinguishing malignant metastatic lesions from benign osteoporotic vertebral compression fractures (VCFs) is a major diagnostic ...