Devices and Vaccines

Simulating speech processing with cochlear implants: How does channel interaction affect learning in neural networks?

We introduce a novel machine learning approach for investigating speech processing with cochlear implants (CIs)-prostheses used to replace a damaged inner ear. Concretely, we use a simple perceptron and a deep convolutional network to classify speech spectrograms that are modified to approximate CI-delivered speech. Implant-delivered signals suffer from reduced spectral resolution, chiefly due to ...

Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or cell populations induced by an immunological response, the role of oxygen in their fate and function is known to be pivotal albeit not well understood i...

Exploration of the nanomedicine-design space with high-throughput screening and machine learning.

Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant ...

Cross-Device Computation Coordination for Mobile Collocated Interactions with Wearables.

Mobile devices, wearables and Internet-of-Things are crammed into smaller form factors and batteries, yet they encounter demanding applications such a...

Development and clinical implementation of SeedNet: A sliding-window convolutional neural network for radioactive seed identification in MRI-assisted radiosurgery (MARS).

PURPOSE: To develop and evaluate a sliding-window convolutional neural network (CNN) for radioactive seed identification in MRI of the prostate after ...

Tuning the Performance of Synthetic Riboswitches using Machine Learning.

Riboswitch development for clinical, technological, and synthetic biology applications constantly seeks to optimize regulatory behavior. Here, we pres...

The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin.

The demand of tetanus antitoxin (TAT) as tetanus treatment in developing and underdeveloped countries is still great since it is relatively easy to ac...

3D printed resin-coated device for uranium (VI) extraction.

Laser-based stereolithography (SLA) 3D printing has been applied to construct a 3D printed device as support for uranium(VI) extraction, using a quate...

Uncertainty optimization of dental implant based on finite element method, global sensitivity analysis and support vector regression.

In this work, an uncertainty optimization approach for dental implant is proposed to reduce the stress at implant-bone interface. Finite element metho...

Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure.

Optical super-resolution microscopy techniques enable high molecular specificity with high spatial resolution and constitute a set of powerful tools i...

Functional expression of porcine interferon-α using a combinational strategy in Pichia pastoris GS115.

Porcine interferon-α (pIFN-α) could be used as the vaccine adjuvant to enhance the antiviral ability of porcine in swine industry. In here, a combinat...

Leveraging Knowledge Representation to Maintain Immunization Clinical Decision Support.

Immunizations are one of the most cost-effective interventions for preventing morbidity and mortality. As vaccines, related clinical knowledge and req...

Disease comorbidity-guided drug repositioning: a case study in schizophrenia.

UNLABELLED: The key to any computational drug repositioning is the availability of relevant data in machine-understandable format. While large amount ...

CbpM and CbpG of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged with a Serotype 19F Pneumococcus.

Among many pneumococcal antigens, choline-binding proteins (CPBs) display a high immunogenicity in animal models. This study aims to determine the imm...

An In Vitro Study to Evaluate and Compare the Hemocompatibility of Titanium and Zirconia Implant Materials after Sandblasted and Acid-etched Surface Treatment.

AIM: This study was aimed to investigate the hemocompatibility of zirconia and titanium implant materials after surface treatment with sandblasting an...

Immunogenicity of Concentrated and Purified Inactivated Avian Influenza Vaccine Formulation.

Avian influenza (AI) H9N2 is a low pathogenic virus subtype belonging to Orthomyxoviridae family. Given the prevalence of this subtype as an infectiou...

Identification of Immune Signatures of Novel Adjuvant Formulations Using Machine Learning.

Adjuvants have long been critical components of vaccines, but the exact mechanisms of their action and precisely how they alter or enhance vaccine-ind...

Identification of Drug-Side Effect Association via Semisupervised Model and Multiple Kernel Learning.

Drug-side effect association contains the information on marketed medicines and their recorded adverse drug reactions. Traditional experimental method...

Hand Exo-Muscular System for Assisting Astronauts During Extravehicular Activities.

Human exploration of the Solar System is one of the most challenging objectives included in the space programs of the most important space agencies in...

CT sinogram-consistency learning for metal-induced beam hardening correction.

PURPOSE: This paper proposes a sinogram-consistency learning method to deal with beam hardening-related artifacts in polychromatic computerized tomogr...