Diabetes

Maternal nutrition and stage of early pregnancy in beef heifers: Impacts on expression of glucose, fructose, and cationic amino acid transporters in utero-placental tissues.

We hypothesized that maternal nutrition and day of gestation would impact utero-placental mRNA expression of the nutrient transporters , , , , and in beef heifers. Crossbred Angus heifers (n = 49) were estrous synchronized, bred via AI, assigned to nutritional treatment (CON = 100% of NRC requirements for 0.45 kg/d gain and RES = 60% of CON) and ovariohysterectomized on d 16, 34, or 50 of gestatio...

Higher concentrations of osteoprotegerin in type 1 diabetic patients are related to retinopathy: Results from the Poznań Prospective Study.

BACKGROUND: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects.

Impact of metformin on serum prostate-specific antigen levels: Data from the national health and nutrition examination survey 2007 to 2008.

PURPOSE: A possible association between metformin use and the development of prostate cancer (PCa) has been reported. However, there is limited inform...

Thyroid disorders in obese patients. Does insulin resistance make a difference?

OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the r...

Estimating glucose requirements of an activated immune system in growing pigs.

Activated immune cells become obligate glucose utilizers, and a large i.v. lipopolysaccharide (LPS) dose causes insulin resistance and severe hypoglyc...

Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe?

The effect of chronic metabolic acidosis (MA) on cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) is largely unknown. There...

Hyperglycemia Is Associated with Surgical Site Infections among General and Vascular Surgery Patients.

Surgical site infection (SSI) is a common cause of morbidity in general and vascular surgery patients. There is inconsistent evidence on the associati...

Can Hyperpolarized C-Urea be Used to Assess Glomerular Filtration Rate? A Retrospective Study.

This study investigated a simple method for calculating the single-kidney glomerular filtration rate (GFR) using dynamic hyperpolarized C-urea magneti...

Image quality classification for DR screening using deep learning.

The quality of input images significantly affects the outcome of automated diabetic retinopathy (DR) screening systems. Unlike the previous methods th...

NEUROPROTECTIVE EFFECT OF BOSWELLIA SERRATA AND ITS ACTIVE CONSTITUENT ACETYL 11-KETO-β-BOSWELLIC ACID AGAINST OXYGEN-GLUCOSE-SERUM DEPRIVATION-INDUCED CELL INJURY.

Oxidative stress plays a key role in pathophysiology of brain ischemia. This study aimed to test whether B. serrata hydroalcoholic extract (BSE) and i...

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.

We demonstrate that model-based unsupervised learning can uniquely discriminate single-cell subpopulations by their gene expression distributions, whi...

Robotic pancreas transplantation in a type 1 diabetic patient with morbid obesity: A case report.

RATIONALE: Obesity is considered a relative contraindication to pancreas transplantation due to increased risks of wound-related complications. Roboti...

Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.

A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical c...

Comparison of machine-learning algorithms to build a predictive model for detecting undiagnosed diabetes - ELSA-Brasil: accuracy study.

CONTEXT AND OBJECTIVE:: Type 2 diabetes is a chronic disease associated with a wide range of serious health complications that have a major impact on ...

Machine Learning and Molecular Dynamics Based Insights into Mode of Actions of Insulin Degrading Enzyme Modulators.

BACKGROUND: Alzheimer's disease (AD) is one of the most common lethal neurodegenerative disorders having impact on the lives of millions of people wor...

Applying Risk Models on Patients with Unknown Predictor Values: An Incremental Learning Approach.

In clinical practice, many patients may have unknown or missing values for some predictors, causing that the developed risk models cannot be directly ...

Deep Diabetologist: Learning to Prescribe Hypoglycemic Medications with Recurrent Neural Networks.

In healthcare, applying deep learning models to electronic health records (EHRs) has drawn considerable attention. This sequential nature of EHR data ...

Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.

Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages ...

Current state of continuous ambulatory peritoneal dialysis in Egypt.

Patients with end-stage renal disease (ESRD) continue to increase in number worldwide, especially in developing countries. Although continuous ambulat...

Pattern and predictors of urine protein excretion among patients with type 2 diabetes attending a single tertiary hospital in Lagos, Nigeria.

Testing for proteinuria is used to screen for diabetic nephropathy. However, significant proportion of diabetics has normal urine protein excretion de...