Diet & Nutrition

Retinoic Acid Excess Impairs Amelogenesis Inducing Enamel Defects.

Abnormalities of enamel matrix proteins deposition, mineralization, or degradation during tooth development are responsible for a spectrum of either genetic diseases termed or acquired enamel defects. To assess if environmental/nutritional factors can exacerbate enamel defects, we investigated the role of the active form of vitamin A, retinoic acid (RA). Robust expression of RA-degrading enzymes ...

Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities.

A new series of 11-keto-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid analogs (5, 7, 8, 10, 13, 18a-d, 27a-c, 28a-d) were synthesized by modification of hydroxyl and acid functional moieties of boswellic acids. The structures of these analogs were confirmed by spectral data analysis (H, C NMR and mass). Compounds 18b, 27a and 8 showed potent 5-lipoxygenase enzyme inhibitory activity (IC...

Quantification of the 3α and 3β epimers of 25-hydroxyvitamin D in dried blood spots by LC-MS/MS using artificial whole blood calibration and chemical derivatization.

While the biological function of the 3α epimer of 25-hydroxyvitamin D (25(OH)D) remains unknown, its presence needs to be accurately captured and sepa...

Effect of vitamin D deficiency on the development of postoperative atrial fibrillation in coronary artery bypass patients.

Various factors may be responsible for the development of postoperative atrial fibrillation (POAF) in coronary artery bypass graft (CABG) patients. I...

Prevalence of Vitamin D Insufficiency in Professional Hockey Players.

BACKGROUND: Vitamin D is a fat-soluble hormone that plays a role in bone health, muscle function, and athletic performance. Studies have shown that lo...

Association of Vitamin D Deficiency and Thyroid Function in Postmenopausal Women.

Although there are reports of vitamin D (VitD) insufficiency in immune-mediated hypothyroidism, an association between VitD and thyroid-stimulating h...

Chlorophyll and total phenolic contents, antioxidant activities and consumer acceptance test of processed grass drinks.

The processed drinks produced from grass of three varieties of rice (Jasmine, Sukhothai 1 and Sukhothai 2) and one each from wheat and barley grasses ...

Effect of energy balance profiles on metabolic and reproductive response in Holstein and Swedish Red cows.

This study examined the effect of two feeding levels during the antepartum and postpartum period on reproductive performance and blood metabolites (gl...

Dietary polyunsaturated fatty acid supplementation of young post-pubertal dairy bulls alters the fatty acid composition of seminal plasma and spermatozoa but has no effect on semen volume or sperm quality.

The aim of this study was to examine the effects of dietary supplementation with rumen protected n-6 or n-3 polyunsaturated fatty acids (PUFA) on the ...

Health impact assessment of the UK soft drinks industry levy: a comparative risk assessment modelling study.

BACKGROUND: In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened beverages (SSBs; high tax for drinks with >8 g of sugar per 10...

Evaluation of genotypic wheat bran varieties for nutraceutical compounds.

The proximate composition and bioactive components were screened in eight wheat bran cultivars such as UAS (304, 415, 428), DWR (162, 185, 1006) and D...

COMPOSE: Using temporal patterns for interpreting wearable sensor data with computer interpretable guidelines.

This paper describes a novel temporal logic-based framework for reasoning with continuous data collected from wearable sensors. The work is motivated ...

Antihemolytic and antioxidant properties of pearl powder against 2,2'-azobis(2-amidinopropane) dihydrochloride-induced hemolysis and oxidative damage to erythrocyte membrane lipids and proteins.

Pearl powder, a well-known traditional mineral medicine, is reported to be used for well-being and to treat several diseases from centuries in Taiwan ...

An Intelligible Risk Stratification Model Based on Pairwise and Size Constrained Kmeans.

Having a system to stratify individuals according to risk is key to clinical disease prevention. This allows individuals identified at different risk ...

A sensitive and rapid UFLC-APCI-MS/MS bioanalytical method for quantification of endogenous and exogenous Vitamin K1 isomers in human plasma: Development, validation and first application to a pharmacokinetic study.

Due to lack of suitable bioanalytical methods in previous literature, for simultaneous estimation of Vitamin K1 isomers, in compliance with the curren...

Influence of post-insemination nutrition on embryonic development in beef heifers.

Previous studies have demonstrated that a decrease in nutrition immediately following AI reduces pregnancy success in beef heifers. The objective of t...

Impact of vitamin D status on statin-induced myopathy.

INTRODUCTION: There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a m...

Integration of metabolomics, lipidomics and clinical data using a machine learning method.

BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either red...

Enhancing analysis throughput, sensitivity and specificity in LC/ESI-MS/MS assay of plasma 25-hydroxyvitamin D by derivatization with triplex 4-(4-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues.

The plasma/serum concentration of 25-hydroxyvitamin D [25(OH)D] is a diagnostic index for vitamin D deficiency/insufficiency, which is associated with...

Cross-sectional survey of the amount of free sugars and calories in carbonated sugar-sweetened beverages on sale in the UK.

OBJECTIVES: To investigate the free sugars and calorie content of carbonated sugar-sweetened beverages (CSSB) available in the main UK supermarkets.