Dyslipidemia

Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery.

Atherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardiovascular threat. Traditional herbs Salvia miltiorrhiza and Carthamus tinctorius exhibit multi-target anti-AS potential, yet their compositional complexity limits clinical translation. This study aimed to systematically identify core anti-AS components from these herbs and enha...

Gut microbiome profiles and associated functional pathways are linked to Mediterranean diet adherence and blood glucose control in adults with type 1 diabetes mellitus.

BACKGROUND AND AIMS: The Mediterranean diet (MD) has been associated with better glycaemic control in children with type 1 diabetes mellitus (T1DM) and favourable microbiome profiles in healthy individuals. However, it remains unclear whether MD adherence is associated with glycaemic control via microbiome. This study examined the relationships among MD adherence, gut microbiome, and glycaemic con...

Personalized adrenal gland volume reference ranges and development of a fully automated deep learning screening tool.

OBJECTIVE: This study aims to develop a low-dose CT-based, fully automated deep learning tool for screening adrenal gland volume abnormalities and est...

Membrane-Penetrating Molecular Device Based on a Triplex Containing Acyclic L-Threoninol Nucleic Acid Functionalized with Cholesterol.

Membrane-penetrating molecular devices are valuable biological tools. Herein, we describe membrane-targeting molecular devices based on the triplexes ...

Clinically oriented deep learning framework for automated vessel wall segmentation in black-blood MRI: a multi-center study.

OBJECTIVES: To develop and validate a clinically applicable deep learning framework for automated segmentation of intracranial and carotid vessel wall...

A machine learning-based discriminative framework for mild cognitive impairment risk in middle-aged and elderly Chinese patients with depression: evidence from CHARLS and CLHLS.

OBJECTIVE: This study aimed to evaluate the application value of machine learning (ML) techniques in the discrimination of mild cognitive impairment (...

Effects of Real-Time Notification of AI-Detected Incidental Coronary Artery Calcium on Statin Prescription: The NOTIFY-PICTURE Trial.

Predicting Heart Failure From 12-Lead ECGs Using AI: A HeartShare/AMP-HF Pooled Cohort Analysis.

BACKGROUND: Artificial intelligence applied to electrocardiograms (ECG-AI) offers a scalable approach to identify individuals at risk for heart failur...

Construction and validation of a hypertensive nephropathy diagnostic model based on mitochondrial-related genes using machine learning combined with WGCNA.

BACKGROUND: Hypertensive nephropathy (HTN) arises from chronic hypertension and may potentially result in severe renal failure. Due to the absence of ...

Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders.

Biomarker research in psychopathology increasingly employs high-dimensional Omics approaches. Yet, proteomics based on human hair remain largely unexp...

Association between triglyceride-glucose index and depression and the mediating role of hypertension: a cross-sectional study of obese adults.

BACKGROUND: Recent findings indicate a positive correlation between the TyG (triglyceride-glucose) index and the incidence of depression. However, the...

AI-driven diagnosis of vulnerable intracranial atherosclerotic plaques using large language models and vision transformers: a multi-center study.

OBJECTIVES: High-resolution vessel wall imaging (HR-VWI) is essential for diagnosing vulnerable intracranial atherosclerotic plaques, but its interpre...

Blood urea nitrogen-to-lipid ratios are novel indices inversely associated with anxiety: Insights from NHANES.

BACKGROUND: Anxiety is a highly prevalent mental disorder linked to metabolic and renal dysregulation. Blood urea nitrogen (BUN) and lipid profiles ha...

Age-specific modifiable determinants and nonlinear risk patterns of habitual low back pain in a large medical check-up cohort: a cross-sectional and longitudinal analysis.

BACKGROUND: Age-related mechanisms underlying habitual low-back pain (LBP) remain poorly defined, with most studies pooling heterogeneous populations ...

Artificial Intelligence-Based Algorithms Improve Care of Patients with AAA.

BACKGROUND: Timely detection and monitoring of abdominal aortic aneurysms (AAAs) are necessary to prevent ruptures and decrease mortality. Artificial ...

Quality control of entomopathogenic nematodes through infrared spectroscopy (FTIR-ATR, 2D-COS): Tracing, modelling and prediction.

Entomopathogenic nematodes (EPNs) are widely used in biological pest control, yet their efficacy in field applications is highly dependent on physiolo...

Exploration and analysis of methylglyoxal-driven chronic inflammation in polycystic ovary syndrome.

INTRODUCTION: Chronic low-grade inflammation drives polycystic ovary syndrome (PCOS)-related metabolic disorders, but the underlying mechanisms remain...

Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group.

Coronary CT angiography is widely implemented, with an estimated 2.2 million procedures in patients with stable chest pain every year in Europe alone....

Incidental Finding of Coronary and Non-Coronary Artery Calcium: What Do Clinicians Need To Know?

PURPOSE OF REVIEW: This review summarizes the role of incidentally and non-incidentally discovered coronary artery calcification (CAC) and the evolvin...

Development and validation of a prognostic model for predicting survival and immunotherapy benefits in melanoma based on metabolism-relevant genes.

Skin cutaneous melanoma (SKCM) is a fatal form of skin cancer. Metabolism-related genes (MRGs) comprise a group of genes that possess the ability to m...