Dyslipidemia

Transfer learning of multicellular organization via single-cell and spatial transcriptomics.

Biological tissues exhibit complex gene expression and multicellular patterns that are valuable to dissect. Single-cell RNA sequencing (scRNA-seq) provides full coverages of genes, but lacks spatial information, whereas spatial transcriptomics (ST) measures spatial locations of individual or group of cells, with more restrictions on gene information. Here we show a transfer learning method named i...

Machine Learning-Based Prediction of Unplanned Readmission Due to Major Adverse Cardiac Events Among Hospitalized Patients with Blood Cancers.

BackgroundHospitalized patients with blood cancer face an elevated risk for cardiovascular diseases caused by cardiotoxic cancer therapies, which can lead to cardiovascular-related unplanned readmissions.ObjectiveWe aimed to develop a machine learning (ML) model to predict 90-day unplanned readmissions for major adverse cardiovascular events (MACE) in hospitalized patients with blood cancers.Desig...

Predicting cerebral infarction and transient ischemic attack in healthy individuals and those with dysmetabolism: a machine learning approach combined with routine blood tests.

Ischemic cerebral infarction is the most prevalent type of stroke, causing significant disability and death worldwide. Transient ischemic attack (TIA)...

Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0-3 and the development of a machine learning prediction model: a nationwide prospective cohort study.

BACKGROUND: The American Heart Association recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome, highlighting the increas...

Risk Factors and Outcomes of Hemorrhagic Transformation in Acute Ischemic Stroke Following Thrombolysis: Analysis of a Single-Center Experience and Review of the Literature.

: This is a retrospective study conducted at the Clinical County Hospital of Craiova, Romania, providing valuable insights into hemorrhagic transforma...

AI-enabled opportunistic measurement of liver steatosis in coronary artery calcium scans predicts cardiovascular events and all-cause mortality: an AI-CVD study within the Multi-Ethnic Study of Atherosclerosis (MESA).

INTRODUCTION: About one-third of adults in the USA have some grade of hepatic steatosis. Coronary artery calcium (CAC) scans contain more information ...

Analysis and validation of hub genes for atherosclerosis and AIDS and immune infiltration characteristics based on bioinformatics and machine learning.

Atherosclerosis is the major cause of cardiovascular diseases worldwide, and AIDS linked with chronic inflammation and immune activation, increases at...

Machine learning-based prediction of LDL cholesterol: performance evaluation and validation.

OBJECTIVE: This study aimed to validate and optimize a machine learning algorithm for accurately predicting low-density lipoprotein cholesterol (LDL-C...

The Influence of an AI-Driven Personalized Nutrition Program on the Human Gut Microbiome and Its Health Implications.

Personalized nutrition programs enhanced with artificial intelligence (AI)-based tools hold promising potential for the development of healthy and su...

Gender Differences in Predicting Metabolic Syndrome Among Hospital Employees Using Machine Learning Models: A Population-Based Study.

BACKGROUND: Metabolic syndrome (MetS) is a complex condition that captures several markers of dysregulation, including obesity, elevated blood glucose...

AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry.

BACKGROUND: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic ...

Comparing machine learning models for osteoporosis prediction in Tibetan middle aged and elderly women.

The aim of this study was to establish the optimal prediction model by comparing the prediction effect of 6 kinds of prediction models containing bioc...

Role of physics-informed constraints in real-time estimation of 3D vascular fluid dynamics using multi-case neural network.

Numerical simulations of fluid dynamics in tube-like structures are important to biomedical research to model flow in blood vessels and airways. It is...

Nutritional predictors of lymphatic filariasis progression: Insights from a machine learning approach.

Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease that causes disfiguring of the affected extremities, often leading to permane...

Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals.

Comorbid cardiovascular and metabolic risk factors (CVM) differentially impact brain structure and increase dementia risk, but their specific magnetic...

Machine learning for predicting metabolic-associated fatty liver disease including NHHR: a cross-sectional NHANES study.

OBJECTIVE: Metabolic - associated fatty liver disease (MAFLD) is a common hepatic disorder with increasing prevalence, and early detection remains ina...

Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.

BACKGROUND: Surrogate insulin resistance (IR) indices are simpler and more practical alternatives to insulin-based IR indicators for clinical use. Thi...

A Novel Mouse Model of Type 2 Diabetes Using a Medium-Fat Diet, Fructose, and Streptozotocin to Study the Complications of Human Disease.

The study of type 2 diabetes mellitus (T2DM) pathophysiology relies mainly on the use of animal models, the most common of which involves the consumpt...

Enhancing cardiovascular risk prediction: the role of wall viscoelasticity in machine learning models.

This study aims to evaluate the significance of wall viscoelasticity in enhancing cardiovascular disease (CVD) risk prediction. We collected data on t...

Early prediction of cardiovascular events following treatments in female breast cancer patients: Application of real-world data and artificial intelligence.

• Application of real-world data and artificial intelligence in detecting cardiotoxicity following cancer treatment. • Clinical features have been use...