Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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Assessment of fatal cardiovascular disease risk using data-driven diabetes subgroups and SCORE2-Diabetes in 24,943 adults in Mexico City

Cardiovascular disease (CVD) is a leading cause of diabetes-related mortality in Mexico. Although diabetes subgroups capture underlying disease heterogeneity, their association and utility for risk prediction for fatal CVD in Mexican adults remain unclear. We analyzed 24,943 adults with diabetes from the Mexico City Prospective Study. Participants were classified into mild obesity-related (MOD), s...

Incorporating Dietary Information to Enhance Polygenic Prediction Models with Applications to Body Mass Index and Type 2 Diabetes

Polygenic predictors can enhance screening for biomedical conditions, such as metabolism-related traits and diseases, but explain limited phenotypic variance and face implementation challenges in non-European populations. On the other hand, dietary quality and other sociocultural factors are well established metabolic risk factors that remain under-investigated in risk stratification models. In th...

Supervoxel-based image-to-biomarker conversions - An initial study on morphological age prediction from whole-body MRI and its clinical relevance in the UK Biobank

Biological aging remains a central focus of research, from the scale of sub-cellular processes to whole-organism tissue morphology and function. In th...

A Tabular Residual Neural Network for Diabetes Classification and Prediction

Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia, with type 1 characterized as an autoimmune destruction of pancreatic be...

Environmental Chemicals as Modifiers of the Association between Age and Ovarian Reserve

To evaluate whether the well-established age-related reduction in antral follicle counts (AFC) is greater among women with higher concentrations of en...

ML-Guided GWAS Reveals Genetic Architectures for MASLD for Overweight and Lean Individuals in the All of Us Cohort

Metabolic dysfunction-associated steatotic liver disease (MASLD) arises from excessive hepatic fat accumulation that triggers inflammation and liver i...

Leveraging Pretrained Large Language Model for Prognosis of Type 2 Diabetes Using Longitudinal Medical Records

Timely prognosis of type 2 diabetes (T2D) is critical for effective interventions and reducing economic burden. Longitudinal medical records offer pot...

Early Detection of Cardiovascular Disease Risk Using Multi-Parameter Biomarker Analysis and Machine Learning: A Prospective Cohort Study

Cardiovascular disease (CVD) remains the leading cause of mortality globally, with many events occurring in individuals without prior diagnosed condit...

Hepatic and abdominal adiposity in type 2 diabetes as assessed with machine learning on CT scans

The distribution of abdominal adipose depots and their mechanistic links to type 2 diabetes remain incompletely understood. This study elucidated the ...

Temporal deep learning with clinically engineered biomarkers for the early prediction of type 2 diabetes

Diabetes mellitus remains a major global health burden, causing an estimated 3.4 million deaths in 2024 and highlighting the need for accurate early i...

Estrogen upregulates NF-κB and TNF signaling in B cells to cause sex and age differences in antibody responses to seasonal influenza vaccination

Sex differences in the humoral immune responses to the seasonal quadrivalent influenza vaccine (QIV) in young adults (YA; 18-49yo) or high dose QIV in...

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern Populations

Type 1 diabetes (T1D) is strongly influenced by HLA variation, yet current genetic risk models developed largely in European cohorts perform suboptima...

Machine Learning-Driven Classification of Type 2 Diabetes Using Gut Microbiome Profiles for Enhanced Detection and Personalised Therapeutics

The purpose of the study is to investigate Type 2 Diabetes Mellitus (T2DM) progression and risk through investigating gut microbiome biomarkers, provi...

Comparing the Treatment and Side Effects of Existing Bariatric Surgery Procedures: An Observational Study

Bariatric surgery is an established treatment for obesity and its associated comorbidities, including diabetes, hypertension, sleep apnea, and hyperch...

Enhancing Early Diabetic Retinopathy Detection through Synthetic DR1 Image Generation: A StyleGAN3 Approach

Diabetic Retinopathy (DR) is a leading cause of preventable blindness. Early detection at the DR1 stage is critical but is hindered by a scarcity of...

A novel approach to finding the compositional differences and biomarkers in gut microbiota in type 2 diabetic patients via meta-analysis, data-mining, and multivariate analysis.

BACKGROUND/PURPOSE OF THE STUDY: Type 2 diabetes mellitus (T2DM)-one of the fastest globally spreading diseases-is a chronic metabolic disorder charac...

Jan 1 2025 40514168
A nomogram for predicting the nature of thyroid adenomatoid nodules on ultrasound: a dual-center study.

PURPOSE: Thyroid Imaging Reporting and Data System (TIRADS) does not perform well in thyroid adenomatoid nodules on ultrasound (TANU). Therefore, we a...

Jan 1 2025 40444082
The multikinetic fusion feature of PPG was combined with MCNN_vision_transformer for diabetes detection.

BACKGROUND: Diabetes is a chronic condition that significantly impacts the cardiovascular system and various other organs. Photoplethysmogram (PPG) si...

Jan 1 2025 40535639
The Hypothalamic Medial Preoptic Area-Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression.

Estrogen fluctuations have been implicated in various mood disorders, including perimenopausal and postpartum depression (PPD), likely through complex...

Jan 1 2025 40370500
Intimate partner violence and stress-related disorders: from epigenomics to resilience.

Intimate Partner Violence (IPV) is a major public health problem to be addressed with innovative and interconnecting strategies for ensuring the psych...

Jan 1 2025 40421256
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