Endocrinology

Using Machine Learning Applied to Real-World Healthcare Data for Predictive Analytics: An Applied Example in Bariatric Surgery.

OBJECTIVES: Laparoscopic metabolic surgery (MxS) can lead to remission of type 2 diabetes (T2D); however, treatment response to MxS can be heterogeneous. Here, we demonstrate an open-source predictive analytics platform that applies machine-learning techniques to a common data model; we develop and validate a predictive model of antihyperglycemic medication cessation (validated proxy for A1c contr...

Machine learning approaches to decipher hormone and HER2 receptor status phenotypes in breast cancer.

Breast cancer prognosis and administration of therapies are aided by knowledge of hormonal and HER2 receptor status. Breast cancer lacking estrogen receptors, progesterone receptors and HER2 receptors are difficult to treat. Regarding large data repositories such as The Cancer Genome Atlas, available wet-lab methods for establishing the presence of these receptors do not always conclusively cover ...

Deep Learning Predicts OCT Measures of Diabetic Macular Thickening From Color Fundus Photographs.

PURPOSE: To develop deep learning (DL) models for the automatic detection of optical coherence tomography (OCT) measures of diabetic macular thickenin...

Continuous Glucose Monitoring Linked to an Artificial Intelligence Risk Index: Early Footprints of Intraventricular Hemorrhage in Preterm Neonates.

OBJECTIVE: To develop and validate a new risk score for intraventricular hemorrhage (IVH) in preterm neonates based on continuous glucose monitoring (...

Deep convolutional neural network models for the diagnosis of thyroid cancer.

Deep convolutional neural network models for the diagnosis of thyroid cancer.

Deep convolutional neural network models for the diagnosis of thyroid cancer - Authors' reply.

Optical biopsy of head and neck cancer using hyperspectral imaging and convolutional neural networks.

For patients undergoing surgical cancer resection of squamous cell carcinoma (SCCa), cancer-free surgical margins are essential for good prognosis. We...

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].

OBJECTIVE: To investigate the effect of the down-regulated expression of pituitary tumor-transforming gene 1 (PTTG1) on the senescence of human castra...

Machine Learning for the Prediction of New-Onset Diabetes Mellitus during 5-Year Follow-up in Non-Diabetic Patients with Cardiovascular Risks.

PURPOSE: Many studies have proposed predictive models for type 2 diabetes mellitus (T2DM). However, these predictive models have several limitations, ...

Fuzzy logic based risk assessment system giving individualized advice for metabolic syndrome and fatal cardiovascular diseases.

In 2005, global cardiovascular diseases caused 30% of deaths in Europe, which is 46% of total deaths for all death groups. Today, according to the Int...

Endometriosis Knowledgebase: a gene-based resource on endometriosis.

Endometriosis is a complex, benign, estrogen-dependent gynecological disorder with an incidence of ~10% women in reproductive age. The implantation an...

DOES THE 25-OH-VITAMIN D LEVEL AFFECT THE INSULIN RESISTANCE IN THE PATIENTS WITH NON-DIABETIC CHRONIC KIDNEY DISEASE?

INTRODUCTION: The aim of this study was to investigate the effects of vitamin D deficiency on insulin resistance in patients with non-diabetic chronic...

Primary Hyperparathyroidism Manifesting with Severe Hypercalcemia in a Nonagenarian Man: Pitfall of Common Imaging Techniques, Localization by 18F-Choline Positron Emission Tomography/Computed Tomography and Successful Management with Calcimimetics.

A nonagenarian hypertensive man with chronic kidney disease (CKD) was admitted to the emergency department for gastrointestinal symptoms and worsening...

Designing an Engineered Construct Gene Sensitive to Carbohydrate In-vitro and Candidate for Human Insulin Gene Therapy In-vivo.

Diabetes is a common disorder worldwide, and exhaustive efforts have been made to cure this disease. Gene therapy has been considered as a potential c...

ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

BACKGROUND: The incidence of adrenal incidentaloma has been increasing proportional to the use of radiologic examination. Multiple endocrine neoplasia...

Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels.

OBJECTIVE: To identify factors that discriminate between transient and permanent congenital hypothyroidism.

[rhPDGF-BB promotes migration of bone marrow stromal stem cells in diabetic rats].

PURPOSE: To evaluate the effect of different concentrations of rhPDGF-BB on bone marrow stromal stem cells(BMSCs) migration in diabetic rat, and relat...

Hypolipidaemic Effects of High Resistant Starch Sago and Red Bean Flour- based Analog Rice on Diabetic Rats.

INTRODUCTION: Sago analog rice had known as an example of food with high resistant starch. Recent research shows that sago analog rice and red bean fl...

In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker.

The corms of Hypoxis argentea are widely used as a traditional remedy for diabetes mellitus in South Africa. In this study, we investigated the effect...