Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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Detection of Non-diabetic Kidney Disease in Patients with Diabetes Using Machine Learning and Electronic Medical Record Data.

INTRODUCTION: The identification of non-diabetic kidney disease (NDKD) in diabetic patients is critically important. Unlike diabetic nephropathy, NDKD often requires additional therapeutic interventions beyond standard diabetes care. There is a need to develop computational methods using electronic medical record data to identify NDKD in diabetic patients for whom kidney biopsy is not an option. M...

Mar 18 2026 41849636

Exosomes in diabetic kidney disease: pathogenesis, biomarker discovery, and emerging therapeutics-a comprehensive systematic review.

Diabetic kidney disease (DKD), characterized by progressive renal dysfunction, is a prevalent microvascular complication of diabetes mellitus and a leading cause of end-stage renal disease worldwide. Despite advances in glycemic and blood pressure control, the incidence and prevalence of DKD continue to escalate, posing a growing public health challenge. Extracellular vesicles, particularly exosom...

Mar 17 2026 41845912
LymphUs: A multicenter open-access database of lymph node ultrasound images in patients with papillary thyroid carcinoma for clinical and artificial intelligence research.

Approximately 30-50% of Papillary thyroid carcinoma (PTC) patients develop cervical lymph nodes (LNs) metastasis, significantly increasing the risk of...

Mar 17 2026 41940127
Artificial intelligence iterative reconstruction in lower extremity computed tomography angiography (CTA) of diabetic patients: Improved visualization of distal and collateral arteries.

BackgroundThe impact of deep learning (DL)-based computed tomography (CT) reconstruction on the visualization of distal and collateral arteries in dia...

Mar 17 2026 41841341
Data-Driven Phenotypic Clusters of Gestational Diabetes Mellitus and Associations With Risk of Perinatal Complications and Postpartum Diabetes.

OBJECTIVE: Management of gestational diabetes mellitus (GDM) largely follows a uniform approach, despite growing recognition of GDM heterogeneity. We ...

Mar 17 2026 41842968
Development of a Machine Learning-based Model for Methimazole Dosage Adjustment in Youth With Hyperthyroidism.

CONTEXT: Accurate methimazole (MMI) dose adjustment in pediatric hyperthyroidism is crucial, but individualized titration relies on clinician experien...

Mar 17 2026 41058080
Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit.

CONTEXT: Adiposomes carry bioactive lipids that shape systemic metabolism and vascular function. OBJECTIVE: Building on our previous findings that obe...

Mar 17 2026 41137449
Joint effects of physical activity and diet quality on depressive symptoms and all-cause mortality in adults with diabetes: NHANES 2007-2018.

Depressive symptoms are common among adults with diabetes and are associated with adverse clinical outcomes, including mortality. Evidence from genera...

Mar 16 2026 41850605
A review on molecular crosstalk: Bioactive polysaccharides and gut microbiota in type 2 diabetes-Pathways, signaling, and therapeutic translation.

Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder characterized by insulin resistance, impaired glucose homeostasis, and low-grade inflam...

Mar 16 2026 41850461
Insulin resistance prediction from wearables and routine blood biomarkers.

Insulin resistance (IR), a primary precursor to type 2 diabetes, is characterized by impaired insulin action in tissues1. However, diagnostic methods ...

Mar 16 2026 41840032
High-Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million-Patient Diabetes Cohort.

Synthetic patient data offer a promising avenue for clinical research, but their usefulness depends on preserving statistical fidelity, biomedical pla...

Mar 16 2026 41834588
The Virtual Diabetes Control and Complications Trial #4: Relationship of HbA1c and Continuous Glucose Monitoring Metrics with Severe Hypoglycemic Events.

OBJECTIVE: To evaluate how continuous glucose monitoring (CGM)-derived metrics relate to severe hypoglycemia (SH) events in individuals with type 1 di...

Mar 16 2026 41837438
Improving the Algorithm: The Inclusion of a Socioeconomic Status Measure in Predicting Type 2 Diabetes Development in Youth With Prediabetes.

OBJECTIVE: To evaluate whether the Area Deprivation Index (ADI) contributes to predicting type 2 diabetes development in youth with prediabetes compar...

Mar 16 2026 41837708
Patient Perceptions of Artificial Intelligence in Diabetes Self-Management: Cross-Sectional Survey Study.

BACKGROUND: Artificial intelligence (AI) is increasingly applied in chronic disease management, including diabetes, where it has the potential to supp...

Mar 16 2026 41838847
An inflammatory biomarker panel for prediabetes classification using interpretable machine learning.

OBJECTIVE: Prediabetes is a silent condition that often goes undetected. However, timely interventions could prevent its progression to type 2 diabete...

Mar 16 2026 41838755
Protective Effect of the FOXO3 Gene in Cardiometabolic Disease in the CHAMP Cohort.

Recent findings from the Honolulu Heart Program cohort in Hawaii suggest a longevity-associated variant of FOXO3 may provide resilience against cardio...

Mar 15 2026 41837379
Toward personalized iodine-131 therapy: A review of dosimetric strategies.

BACKGROUND: Iodine-131 (131I) therapy is a cornerstone of nuclear medicine for thyroid diseases and certain cancers. This review evaluates the transit...

Mar 14 2026 41905153
Adrenal Incidentalomas: Modern Tools to Address a Condition of Modern Times.

Adrenal incidentalomas are a modern-day problem, which has slowly been met by modern day technological innovations. Further characterization of adrena...

Mar 14 2026 42067268
Use of continuous glucose monitoring to stratify individuals without diabetes.

BACKGROUND: Early detection of metabolic dysfunction before diabetes onset remains a critical challenge in preventive medicine. Although glucose dynam...

Mar 14 2026 41832215
Integrated cortical-cognitive signatures identified by machine learning enable early detection of MCI in type 2 diabetes.

Type 2 Diabetes Mellitus (T2DM) confers a significant risk for Mild Cognitive Impairment (MCI), yet robust biomarkers for early detection remain limit...

Mar 14 2026 41832340
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