Environmental Health

Genotoxicity in lead treated human lymphocytes evaluated by micronucleus and comet assays.

Lead (Pb) which plays a significant role in modern industry is related to a broad range of physiological, biochemical, behavioural and genetical dysfunctions. Its exposure leads to an increased frequency of genetic aberrations in humans. Hence, this study was designed to assess the genotoxic effect of lead acetate at three dosage levels (10, 25 and 50 µg/mL) by employing: the Cytokinesis Block Mic...

Generalized Multifactor Dimensionality Reduction (GMDR) Analysis of Drug-Metabolizing Enzyme-Encoding Gene Polymorphisms may Predict Treatment Outcomes in Indian Breast Cancer Patients.

BACKGROUND: Prediction of response and toxicity of chemotherapy can help personalize the treatment and choose effective yet non-toxic treatment regimen for a breast cancer patient. Interplay of variations in various drug-metabolizing enzyme (DME)-encoding genes results in variable response and toxicity of chemotherapeutic drugs. Generalized multi-analytical (GMDR) approach was used to determine th...

Can a video game company tame toxic behaviour?

Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.

Poor pharmacokinetic and toxicity profiles are major reasons for the low rate of advancing lead drug candidates into efficacy studies. The In-silico p...

An Evaluation on Different Machine Learning Algorithms for Classification and Prediction of Antifungal Peptides.

BACKGROUND: Fungi are an emerging threat in medicine and agriculture and current therapeutics have proved to be insufficient and toxic. This has led t...

Anticancer Activity a of Caspian Cobra () snake Venom in Human Cancer Cell Lines Via Induction of Apoptosis.

Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new antica...

Pharmacokinetics of Amitriptyline HCl and Its Metabolites in Healthy African Grey Parrots ( Psittacus erithacus ) and Cockatoos (Cacatua Species).

Amitriptyline, a tricyclic antidepressant, is used clinically to treat feather-destructive behavior in psittacine birds at a recommended dosage of 1-5...

Validation of an UV spectrophotometric assay for the quantification of polymyxin B in solid lipid nanoparticles.

Polymyxins are efficient antibiotic drugs used for the treatment of Gram-negative bacterial infections. These compounds are not absorbed in the gastro...

Bubble-free electrokinetic flow with propylene carbonate.

For electroosmotic pumping, a large direct-current (DC) electric field (10+ V/cm) is applied across a liquid, typically an aqueous electrolyte. At the...

Part 1. Statistical Learning Methods for the Effects of Multiple Air Pollution Constituents.

INTRODUCTION: The United States Environmental Protection Agency (U.S. EPA*) currently regulates individual air pollutants on a pollutant-by-pollutant ...

Application of artificial neural networks for prediction of photocatalytic reactor.

In this paper, forecasting of kinetic constant and efficiency of photocatalytic process of TiO2 nano powder immobilized on light expanded clay aggrega...

In silico assessment of the acute toxicity of chemicals: recent advances and new model for multitasking prediction of toxic effect.

The assessment of acute toxicity is one of the most important stages to ensure the safety of chemicals with potential applications in pharmaceutical s...

Visfatin and TGF-Β1 in primary biliary cirrhosis and two other common liver diseases.

UNLABELLED: The aim of this study is to investigate plasma concentration of visfatin and transforming growth factor Β1 (TGF-Β1) in three groups of pat...

[Monitoring of the Moskva River Water Using Microbiological Parameters and Chlorophyll a Fluorescence].

The results of investigations of three Moskva River sites with different degree of pollution using a complex of microbiological characteristics and th...