Environmental Health

Bacterial laccases for green remediation of contaminants of emerging concern: from molecular cloning to metagenomic and computational insights.

Contaminants of emerging concern (CECs) are increasingly recognized for their persistence, widespread occurrence, and potential risks to environmental and human health. Their frequent detection in wastewater, surface water, drinking water, and food chains underscores the urgent need for sustainable remediation strategies. Laccases, versatile multicopper oxidases, have demonstrated strong potential...

Computational and AI-Driven Ecosystem for Structure-Based Covalent Drug Discovery.

ConspectusThe field of covalent drug discovery has witnessed a remarkable resurgence in recent years, a trend underscored by the approval of more than 125 covalent drugs by the US FDA as of 2025, which demonstrates their immense therapeutic potential. Driven by ever-increasing computational power and vast amounts of data, deep learning (DL) is profoundly transforming numerous fields, from natural ...

Advances in air quality modeling through artificial intelligence, machine learning, and deep learning: A comprehensive review.

Air quality modeling is undergoing a significant transformation, as machine learning (ML) and deep learning (DL) emerge to address the inherent limita...

Leveraging machine learning algorithm to predict minimum dietary diversity among children aged 6-23 months in Ethiopia.

Lack of nutrient-rich food consumption is considered an important underlying factor affecting the healthy development of children, and can lead to dev...

Hydrodynamic modulation of microplastic bioaccumulation in edible fish: Integrating biomarker networks, machine learning, and food safety perspectives.

Microplastic (MP) pollution poses increasing environmental and food safety risks, yet the role of hydrodynamics in MPs bioaccumulation and fish physio...

Sustainable All-Inorganic Double Perovskite Memristors Enabling Synaptic Learning and Cognitive Emulation.

Lead-free halide perovskites are emerging as sustainable alternatives for next-generation electronic and neuromorphic technologies. In this work, we p...

Molecular Representation and Closed-Loop Validation for Toxicity Assessment of Organic Compounds in Ambient Air PM2.5.

Although the health impacts of fine particulate matter (PM2.5) are primarily attributed to its chemically diverse composition rather than to mass conc...

Exploring Reddit Discourse and Information Needs Surrounding Extreme Heat: Topic, Sentiment, and Engagement Analysis.

BACKGROUND: As Canada's climate changes, extreme heat events have become more frequent, a trend that is expected to continue. Extreme heat can lead to...

Four-electrode ECG reconstruction using anatomically grounded synthetic leads: a physiological measurement framework with hybrid CNN-transformer mapping.

The standard 12-lead electrocardiogram (ECG) remains essential for cardiac diagnosis but requires ten physical electrodes, limiting long-term and...

Mitigating mammalian cell cytotoxicity of drinking water upon chlorination by conventional and advanced treatment processes.

Ozone (O3)-biological activated carbon (BAC) advanced treatment is increasingly applied after conventional coagulation-sedimentation for controlling t...

Prediction of preparation conditions for low PAHs corn straw biochar guided by CatBoost model optimized via genetic algorithm and molecular dynamics simulation.

Biochar shows great potential in cultivated soil improvement, but its polycyclic aromatic hydrocarbons (PAHs) are toxic and may threaten ecological se...

Integrative metabolomics and machine learning reveal the toxic mechanisms of elaidic acid in polycystic ovary syndrome.

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunction and metabolic disturbances, including obesity, insulin resis...

Advances and Sustainable Implementation of Nanomaterials in Water Remediation: A Comprehensive Review.

To overcome global water scarcity and pollution, nanomaterials have emerged as revolutionary tools for water remediation owing to their unique physico...

Environmental PET-microplastic exposure and risk of non-alcoholic fatty liver disease: An integrated computational toxicology and multi-omics study.

The escalating severity of global microplastic pollution has triggered significant public health concerns. Polyethylene terephthalate (PET), a ubiquit...

A fuzzy ZE-number group decision-making framework using BWM and MABAC for risk assessment in medicinal plant extraction.

The extraction of bioactive compounds from medicinal plants is a crucial process in pharmaceutical and herbal medicine industries, yet it presents num...

Reliable detection of focal onset impaired awareness seizures in patients with epilepsy using wearable ECG: Development and validation study.

BACKGROUND: Underreporting of seizures, particularly focal onset impaired awareness seizures (FIAS), compromises the effectiveness of patient care and...

ParetoGen: Generative Machine Learning Models To Push the Pareto Optimal Frontier of Functionality-Hazard Trade-offs in Per- and Polyfluoroalkyl Substances Green Alternative Designs.

Faced with chemical pollution that has exceeded the planetary boundaries, endeavors must be directed toward designing green alternatives to reduce the...

Human and environmental controls on soil contamination in a dust-prone region revealed by random forest and Shapley additive explanations analysis.

Accurate prediction of the spatial distribution of potentially toxic elements (PTEs) and identification of the most important environmental drivers ar...

Deciphering the air pollution-osteoarthritis relationship: insights from network toxicology, integrated machine learning, and molecular docking.

Mounting evidence suggests an association between air pollution and the pathogenesis of osteoarthritis (OA), yet the underlying molecular mechanisms r...

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi-Omics.

Air pollution (AP), intensified by industrialization and urbanization, is a key environmental factor linked to rheumatoid arthritis (RA). However, its...