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Three Decades of FDA Authorizations of AI/ML Enabled Medical Devices: Persistent Specialty Concentration and the Care Delivery Gap (1995 to 2025)

The US Food and Drug Administration (FDA) maintains a public list of artificial intelligence and machine learning (AI/ML)-enabled medical devices that have received marketing authorization. Prior published analyses examined this list at earlier time points and reported a marked dominance of radiology applications. We performed a cross-sectional analysis of all 1,430 AI/ML-enabled medical device au...

Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction

Background: Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are persistent organic pollutants ubiquitous in the environment. Epidemiological evidence has closely linked them to an elevated risk of prostate cancer (PCa). However, the precise molecular mechanisms by which combined PFOS/PFOA exposure promotes prostate cancer...

Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicity

Background: Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity remains a significant clinical challenge. Current appr...

BioMADE: Predicting Torsades de Pointes from molecular structures through biologically informed representations

Drug-induced arrhythmias, particularly Torsades de Pointes (TdP), pose a significant risk to patient safety and can sometimes have life-threatening ou...

Automated Detection of Abnormalities in Zebrafish Development

Zebrafish embryos are a valuable model for drug discovery due to their optical transparency and genetic similarity to humans. However, current evaluat...

May 11 2026 2605.10464v1
MMVIAD: Multi-view Multi-task Video Understanding for Industrial Anomaly Detection

Industrial anomaly detection is critical for manufacturing quality control, yet existing datasets mainly focus on static images or sparse views, which...

May 11 2026 2605.10833v1
SAIL: Structure-Aware Interpretable Learning for Anatomy-Aligned Post-hoc Explanations in OCT

Optical coherence tomography (OCT), a commonly used retinal imaging modality, plays a central role in retinal disease diagnosis by providing high-reso...

May 4 2026 2605.02707v1
From Prediction to Practice: A Task-Aware Evaluation Framework for Blood Glucose Forecasting

Clinical time-series forecasting is increasingly studied for decision support, yet standard aggregate metrics can obscure whether a model is actually ...

May 1 2026 2605.00645v1
Systems Pharmacology Reveals Type I Interferon and Myeloid-Like B Cell Reprogramming as Druggable Axes in Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) lacks targeted therapies beyond anticoagulation, and its molecular heterogeneity remains poorly characterized. We empl...

DrugPTM-Bench: A Large-Scale Dataset for Predictive Modeling of Drug-Induced Cell Type-Specific Protein Post-Translational Modifications

Protein post-translational modifications (PTMs), particularly phosphorylation, serve as the primary molecular switches that orchestrate cellular signa...

Robust Lightweight Crack Classification for Real-Time UAV Bridge Inspection

With the widespread application of Unmanned Aerial Vehicles (UAVs) in bridge structural health monitoring, deep learning-based automatic crack detecti...

Apr 30 2026 2604.27617v1
Interpretable Transformer-Based Phase Recognition for Transabdominal Preperitoneal Laparoscopic Inguinal Hernia Repair

Background: Surgical phase recognition is a critical prerequisite for context-aware operating rooms and automated skill assessment. While artificial i...

Real-time prospective (shadow mode) validation of an AI-based clinical decision support system for predicting 3-month functional outcome in acute stroke: the VALIDATE study protocol

Introduction Despite the proven benefits of reperfusion therapies in acute ischemic stroke, treatment decisions in the hyperacute phase remain complex...

Graph-augmented Segmentation of Complex Shapes in Laser Powder bed Fusion for Enhanced In Situ Inspection

The technological maturity of in situ inspection and monitoring methods in additive manufacturing is steadily increasing, enabling more efficient and ...

Apr 27 2026 2604.24234v1
SolarFCD: A Large-Scale Dataset and Benchmark for Solar Fault Classification in Photovoltaic Systems

The increasing global deployment of solar photovoltaic (PV) systems needs robust, scalable, and automated inspection technologies capable of detecting...

Apr 26 2026 2604.23662v1
Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on an ancient disease with persistent, unresolved problems (DS-IAFRICA TB) study protocol

Tuberculosis (TB) is prevalent in Uganda and overlaps with a high rate of HIV/TB coinfection. While nearly all hospital-based TB cases in Kampala, the...

FryNet: Dual-Stream Adversarial Fusion for Non-Destructive Frying Oil Oxidation Assessment

Monitoring frying oil degradation is critical for food safety, yet current practice relies on destructive wet-chemistry assays that provide no spatial...

Apr 23 2026 2604.21321v1
SemiFA: An Agentic Multi-Modal Framework for Autonomous Semiconductor Failure Analysis Report Generation

Semiconductor failure analysis (FA) requires engineers to examine inspection images, correlate equipment telemetry, consult historical defect records,...

Apr 14 2026 2604.13236v1
Analog Optical Inference on Million-Record Mortgage Data

Analog optical computers promise large efficiency gains for machine learning inference, yet no demonstration has moved beyond small-scale image benchm...

Apr 14 2026 2604.13251v1
No One Left Behind: Adaptive Tablet Modalities for Digitally Excluded Emergency Department Patients Design, Implementation, and Social Evidence for an Impairment-First Interface

Background: The urgent care departments in Europe face a structural paradox: accelerating digitalisation is accompanied by a patient population that i...

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