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The Rise of Clinical Decision Support Algorithms in Pain Management 2009-2024.

This paper examines the rise of clinical decision support algorithms used to assess risk in pain management and the opioid industry's influence on their development and implementation. To understand this influence, we conducted a qualitative study of documents related to the development of a tool that relied on artificial intelligence (AI) to suggest modifications in opioid prescribing, called Nar...

May 12 2025 40355787

Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides.

Identifying host defense peptides (HDPs) that are effective against drug-resistant infections is challenging due to their vast sequence space. Artificial intelligence (AI)-guided design can accelerate HDP discovery, but it traditionally requires large data sets to operationalize. We report an AI workflow that utilizes limited data sets (∼100 peptides) to uncover potent, selective, and safe HDPs by...

May 12 2025 40310992
Dendritic cell-based microrobots for enhanced systemic antigen-specific immune tolerance.

Current immunotherapeutic approaches for autoimmune disorders primarily rely on the use of generalized immunosuppressive medications. However, most im...

May 10 2025 40010412
Artificial Intelligence in Medicine and Imaging Applications.

Artificial intelligence (AI) can completely transform drug development methods by delivering faster, more accurate, efficient results. However, the ef...

May 9 2025 40353469
Image2Reg: Linking chromatin images to gene regulation using genetic and chemical perturbation screens.

Representation learning provides an opportunity to uncover the link between 3D genome organization and gene regulatory networks, thereby connecting th...

May 9 2025 40359941
Quantitative Analysis of 3-Monochloropropane-1,2-diol in Fried Oil Using Convolutional Neural Networks Optimizing with a Stepwise Hybrid Preprocessing Strategy Based on Fourier Transform Infrared Spectroscopy.

As one kind of 'probable human carcinogen' (Group 2B) compound classified by the International Agency for Research on Cancer, 3-MCPD is mainly formed ...

May 9 2025 40428450
Value of Bioinformatics Models for Predicting Translational Control of Angiogenesis.

Angiogenesis, the formation of new blood vessels, is a fundamental biological process with implications for both physiological functions and pathologi...

May 9 2025 40339045
Editorial Commentary: Deteriorated Quality and Medial Retraction of Tendon Following Acute Traumatic Rotator Cuff Tear Are Predictors of Retear After Arthroscopic Repair.

Rotator cuff tears are a common cause of shoulder pain and dysfunction, affecting up to 33% of the population, and approximately 250,000 arthroscopic ...

May 9 2025 40349803
Advanced 3D Imaging Approach to TSV/TGV Metrology and Inspection Using Only Optical Microscopy

This paper introduces an innovative approach to silicon and glass via inspection, which combines hybrid field microscopy with photometric stereo. Co...

Revisiting the role of steroidal therapeutics in the 21st century: an update on FDA approved steroidal drugs (2000-2024).

Steroids are biologically active polycyclic compounds that have garnered significant scientific attention due to their distinct physiochemical propert...

May 8 2025 40352672
With Friends Like These, Who Needs Explanations? Evaluating User Understanding of Group Recommendations

Group Recommender Systems (GRS) employing social choice-based aggregation strategies have previously been explored in terms of perceived consensus, ...

The state of artificial intelligence-enabled skin cancer diagnostics: Why are there two spectroscopy devices available yet no imaging devices?

Artificial intelligence (AI) is already impacting the way we diagnose skin diseases. Although there are many new AI tools promoted to be helpful to de...

May 7 2025 40345350
Ethical and legal considerations in healthcare AI: innovation and policy for safe and fair use.

Artificial intelligence (AI) is transforming healthcare by enhancing diagnostics, personalizing medicine and improving surgical precision. However, it...

May 1 2025 40370601
Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo.

The study of ubiquitous circadian rhythms in human physiology requires regular measurements across time. Repeated sampling of the different internal t...

May 1 2025 40424435
Repurposing FDA-approved drugs as NLRP3 inhibitors against inflammatory diseases: machine learning and molecular simulation approaches.

Activation of NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) has been associated with multiple chronic pathologies, including dia...

May 1 2025 38400742
Artificial intelligence software in biomedical imaging: a pharmaceutical perspective on radiology and contrast-enhanced ultrasound applications.

Artificial intelligence (AI) is rapidly transforming radiology, with over 200 CE-marked products in the EU and more than 750 AI-based devices authoris...

May 1 2025 40338060
Glucagon and insulin production in pancreatic cells modeled using Petri nets and Boolean networks

Diabetes is a civilization chronic disease characterized by a constant elevated concentration of glucose in the blood. Many processes are involved i...

Dual-Branch Residual Network for Cross-Domain Few-Shot Hyperspectral Image Classification with Refined Prototype

Convolutional neural networks (CNNs) are effective for hyperspectral image (HSI) classification, but their 3D convolutional structures introduce hig...

Fluorescence Reference Target Quantitative Analysis Library

Standardized performance evaluation of fluorescence imaging systems remains a critical unmet need in the field of fluorescence-guided surgery (FGS)....

Semantic Similarity-Informed Bayesian Borrowing for Quantitative Signal Detection of Adverse Events

We present a Bayesian dynamic borrowing (BDB) approach to enhance the quantitative identification of adverse events (AEs) in spontaneous reporting s...

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