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Molecular MRI-Based Monitoring of Cancer Immunotherapy Treatment Response.

Immunotherapy constitutes a paradigm shift in cancer treatment. Its FDA approval for several indications has yielded improved prognosis for cases where traditional therapy has shown limited efficiency. However, many patients still fail to benefit from this treatment modality, and the exact mechanisms responsible for tumor response are unknown. Noninvasive treatment monitoring is crucial for longit...

Feb 5 2023 36834563

Pharma's Bio-AI revolution.

Drug development has become unbearably slow and expensive. A key underlying problem is the clinical prediction challenge: the inability to predict which drug candidates will be safe in the human body and for whom. Recently, a dramatic regulatory change has removed FDA's mandated reliance on antiquated, ineffective animal studies. A new frontier is an integration of several disruptive technologies ...

Feb 2 2023 36736581
Explainable artificial intelligence as a reliable annotator of archaeal promoter regions.

Archaea are a vast and unexplored cellular domain that thrive in a high diversity of environments, having central roles in processes mediating global ...

Jan 31 2023 36720898
A universal deep-learning model for zinc finger design enables transcription factor reprogramming.

CysHis zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for programmable regulation o...

Jan 26 2023 36702896
Software-related recalls in computer-assisted hip and knee arthroplasty.

PURPOSE: Computer-assisted arthroplasty supports the surgeons in planning, simulating, and performing the replacement procedure, using robotic or navi...

Jan 13 2023 36637462
Identification of Glucose Transport Modulators In Vitro and Method for Their Deep Learning Neural Network Behavioral Evaluation in Glucose Transporter 1-Deficient Mice.

Metabolic flux augmentation via glucose transport activation may be desirable in glucose transporter 1 (Glut1) deficiency syndrome (G1D) and dementia,...

Jan 12 2023 36635085
Applications of deep learning in understanding gene regulation.

Gene regulation is a central topic in cell biology. Advances in omics technologies and the accumulation of omics data have provided better opportuniti...

Jan 11 2023 36814848
Improving Concrete Crack Segmentation Networks through CutMix Data Synthesis and Temporal Data Fusion.

A key element in an automated visual inspection system for concrete structures is identifying the geometric properties of surface defects such as crac...

Jan 2 2023 36617106
Considerations for Creating a Restricted Data Environment with Complete Primary Care Electronic Medical Record Data.

Background: Historically, primary care databases have been limited to subsets of the full electronic medical record (EMR) data to maintain privacy. Wi...

Jan 1 2023 36972526
Artificial Intelligence-Assisted Digital Immunoassay Based on a Programmable-Particle-Decoding Technique for Multitarget Ultrasensitive Detection.

The development of a multitarget ultrasensitive immunoassay is significant to fields such as medical research, clinical diagnosis, and food safety ins...

Dec 26 2022 36571573
miDruglikeness: Subdivisional Drug-Likeness Prediction Models Using Active Ensemble Learning Strategies.

The drug development pipeline involves several stages including in vitro assays, in vivo assays, and clinical trials. For candidate selection, it is i...

Dec 23 2022 36671415
Inconsistent Partitioning and Unproductive Feature Associations Yield Idealized Radiomic Models.

Background Radiomics is the extraction of predefined mathematic features from medical images for the prediction of variables of clinical interest. Whi...

Dec 20 2022 36537895
Automated Identification of Overheated Belt Conveyor Idlers in Thermal Images with Complex Backgrounds Using Binary Classification with CNN.

Mechanical industrial infrastructures in mining sites must be monitored regularly. Conveyor systems are mechanical systems that are commonly used for ...

Dec 19 2022 36560373
A Robust Deep Learning Ensemble-Driven Model for Defect and Non-Defect Recognition and Classification Using a Weighted Averaging Sequence-Based Meta-Learning Ensembler.

The need to overcome the challenges of visual inspections conducted by domain experts drives the recent surge in visual inspection research. Typical m...

Dec 17 2022 36560340
Operon Finder: A Deep Learning-based Web Server for Accurate Prediction of Prokaryotic Operons.

Operons are groups of consecutive genes that transcribe together under the regulation of a common promoter. They influence protein regulation and vari...

Dec 14 2022 37356898
Artificial intelligence in cancer research and precision medicine: Applications, limitations and priorities to drive transformation in the delivery of equitable and unbiased care.

Artificial intelligence (AI) has experienced explosive growth in oncology and related specialties in recent years. The improved expertise in data capt...

Dec 11 2022 36527795
A multi-perspective information aggregation network for automated-staging detection of nasopharyngeal carcinoma.

Accurate-staging is important when planning personalized radiotherapy. However,-staging via manual slice-by-slice inspection is time-consuming while t...

Dec 9 2022 36541557
The Impact of SO Emissions Trading Scheme on Firm's Environmental Performance: A Channel from Robot Application.

Improving the environmental performance of enterprises is the key to achieving the goal of energy conservation, emission reduction and green developme...

Dec 8 2022 36554360
Robot-Assisted Rehabilitation Architecture Supported by a Distributed Data Acquisition System.

Rehabilitation robotics aims to facilitate the rehabilitation procedure for patients and physical therapists. This field has a relatively long history...

Dec 6 2022 36502234
Off the deep end: What can deep learning do for the gene expression field?

After a COVID-related hiatus, the fifth biennial symposium on Evolution and Core Processes in Gene Regulation met at the Stowers Institute in Kansas C...

Nov 30 2022 36462664
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