Flu & URI

Quantitative three-dimensional imaging of Coxiella burnetii infection by focused ion beam-scanning electron microscopy.

Coxiella burnetii is a highly virulent intracellular pathogen and the causative agent of acute and chronic Q fever in humans. Central to its pathogenicity is the Dot/Icm type IV secretion system, which translocates more than 100 effector proteins into host cells to drive the biogenesis of Coxiella-containing vacuoles (CCVs), which are specialized, lysosome-derived compartments that support bacteri...

Therapeutic targeting of Respiratory Syncytial Virus: Current pharmacological options and future directions in antiviral development.

Respiratory syncytial virus (RSV) remains a major cause of severe acute respiratory infections across the life course, particularly in infants, older adults, and immunocompromised individuals. For decades, clinical management relied almost exclusively on supportive care, while ribavirin, the only licensed antiviral, offered limited therapeutic benefit. The recent introduction of prefusion F (pre-F...

Advances in mosquito-borne disease surveillance using machine learning.

Mosquito-borne diseases remain a major global health challenge, disproportionately impacting low- and middle-income countries. Despite traditional con...

Adjuvant databases and knowledge bases for data-driven research: a computational biology perspective.

In adjuvant research, which has long relied on experience and trial and error, advancements in technologies in broad areas, including artificial intel...

Atomic clarity: how structural biology is shaping blood-stage malaria vaccines.

Developing an effective malaria vaccine is challenging because Plasmodium parasites use complex strategies to invade host cells. The blood stage, wher...

Influenza forecasting method based on dual-chan nel feature fusion of VMD decomposition.

Accurate influenza forecasting is critical for timely public health responses and resource allocation. To address challenges such as strong non-statio...

Predicting Expiration Among Potential Donation after Circulatory Death Donors at 30- and 120 Minutes Post Extubation.

PURPOSE: Many potential Donation After Circulatory Death (DCD) donors do not progress to circulatory death within meaningful timeframes, leading to wa...

A hybrid ensemble approach: fusing ANFIS, LSTM, and LSSVM with PSO for enhanced influenza a forecasting.

Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies.

BACKGROUND: The infection of high-risk human papillomavirus (hr-HPV) and related cervical cancer have greatly threatened women's health. However, the ...

A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives.

Ferritin, a natural iron-storage protein, has emerged as a versatile platform in nanotechnology and biomedicine due to its biocompatible 12 nm nanocag...

Amyloidosis secondary to familial Mediterranean fever: machine learning-based prediction models.

OBJECTIVES: Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by MEFV mutations, with amyloidosis as its most severe c...

Decoding viral evolution through integrative bioinformatics: From genomes to global health.

Bioinformatics has transformed modern virology by linking genomic variation to epidemiology, protein structure, and public health action. This review ...

Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Alt...

TREM-1-Associated Neutrophil Extracellular Trap Formation is Linked to IVIG Resistance in Kawasaki Disease: A Convergent Transcriptomic and Prospective Validation Study.

Kawasaki disease (KD) remains the leading cause of acquired heart disease in children. While intravenous immunoglobulin (IVIG) represents standard the...

Isolated Nausea and Pretibial Rash in a Returning Traveler: Forme Fruste of Leptospirosis.

Leptospirosis is difficult to diagnose because of protean nonspecific clinical manifestations and the lack of rapid, actionable laboratory testing. A ...

Serum-antibody Profiling of H3N2-infected Ferrets Using a Combinatorial Phage-display Random Peptide Library.

The repertoire of antibodies in serum, known as the "IgOme", is highly diverse and unique to each individual as it reflects the cumulative history of ...

Can Algorithms Efficiently Identify Interpretable and Persuasive Message Features? An Agnostic Causal Machine Learning Approach.

Argument strength and message persuasiveness are key constructs in message effects research. Yet, researchers still lack a systematic and efficient ap...

Explainable artificial intelligence-enabled intertwined logistics analytics with application in poultry vaccine distribution in the Northwest of Iran.

Intertwining supply chains integrates the corresponding networks across several intersection points, such as suppliers, manufacturers, and transporter...

Development and validation of the Oxford Attitudes to Artificial Intelligence in Medicine Scale.

OBJECTIVE: Public willingness to accept medical artificial intelligence (AI) tools affect the potential real-world impact of these evolving technologi...

mRNASyner: An Integrative Framework for Full-Length mRNA Sequence Optimization via Multimodule Synergistic Design.

Messenger RNA (mRNA) technology holds great promise in biomedicine; however, its therapeutic efficacy relies heavily on translation efficiency and the...