Flu & URI

Competing gene regulatory networks drive naive and memory B cell differentiation.

Elucidating the gene regulatory networks (GRNs) that control human B cell differentiation is crucial for understanding immune responses to infection, vaccination, and autoimmunity. Here, we map the GRNs guiding naive and memory B cell differentiation. Early in activation, both cell types engage highly similar GRNs. However, at later stages, naive B cells diverge into two opposing GRNs that promote...

A review of traditional uses, phytoconstituents, bioactivities, and therapeutic potential of Hypecoum erectum L. and Hypecoum leptocarpum Hook.f. & Thomson.

ETHNOPHARMACOLOGICAL RELEVANCE: Hypecoi Erecti Herba, derived from plants of the genus Hypecoum (Papaveraceae), includes two source species: Hypecoum leptocarpum Hook.f. & Thomson and Hypecoum erectum L. It is widely distributed across northern, northwestern, and southwestern China, Mongolia, Russia, and many South and West Asian countries. In traditional medical systems, particularly Tibetan and ...

Machine-Learning Microfluidic Minute-Scale Microorganism Metrics Monitoring(M6).

On-site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion,...

Predicting Postoperative Outcomes in Pediatric Ureteroscopy Using Machine Learning and Explainable AI-EAU Endourology Vision-AI Study.

AIM OF THE STUDY: This study aimed to evaluate the performance of machine learning (ML) algorithms integrated with explainable artificial intelligence...

Generative artificial intelligence-driven chatbots and medical misinformation: an accuracy, referencing and readability audit.

OBJECTIVES: Artificial intelligence (AI)-driven chatbots have been rapidly adopted across research, education, business, marketing and medicine. Most ...

Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies.

BACKGROUND: Bangladesh has a noticeable rise in vector-borne diseases (VBD) attributed to climate change. Accurately mapping, predicting, and identify...

Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent.

Personalized cancer vaccines have re-emerged as a promising strategy in precision immunotherapy, driven by advances in tumor sequencing, neoantigen id...

Artificial intelligence at the frontlines: Emerging infectious and parasitic diseases in the digital era.

Emerging infectious diseases are one of the most significant threats to global health, driven by many factors such as zoonotic spillovers, climate cha...

Artificial Intelligence in Asthma: From Diagnosis to Management.

Artificial intelligence (AI) offers new opportunities to improve asthma management across the care process. This review synthesizes evidence on AI app...

Comparison of Artificial Intelligence Tools With Human Coding for Sentiment, Topic, and Thematic Analysis Tasks of Public Health Datasets During the COVID-19 Pandemic in Australia: Case Study.

BACKGROUND: Public opinion, which may be influenced by personal experiences, news, and social media, can impact compliance with public health measures...

Genome Database for Vaccinium: a knowledgebase for genetics, genomics, and breeding research.

The Genome Database for Vaccinium (GDV, https://www.vaccinium.org/) is a knowledgebase serving the global Vaccinium research community. GDV centralize...

High-Throughput Image-Based Pupal Sex Classification in Aedes aegypti Using Convolutional Neural Network Models for Sterile Insect Technique Applications.

Aedes aegypti, the primary vector of dengue, yellow fever, Zika, and chikungunya, poses serious public health threats, especially in tropical regions....

"Can a chatbot be used in the full-text screening in a systematic review?".

INTRODUCTION: Large language model-based artificial intelligence tools are increasingly explored to support systematic reviews, yet evidence regarding...

Forecasting influenza activity based on internet retrieval behavior and meteorological data in four megacities of China.

BACKGROUND: Accurate and timely early warning of seasonal influenza epidemics continues to pose a critical public health challenge. Innovative methodo...

Efficacy of swine Influenza A virus vaccines on transmission, viral shedding and clinical signs: Systematic review and meta-analysis.

Swine influenza A viruses (swIAV) are a major cause of respiratory disease in pigs, and vaccination remains the main control strategy. The objective o...

Small but mighty: Peptides as next-generation immunotargeting agents in gynecological cancers.

The most common cancers in women, ovarian, cervical and endometrial, are still a significant cause of cancer-related illness and death around the worl...

mRNA vaccines in cancer immunotherapy: current progress and perspectives in solid tumors and hematologic malignancies.

The unprecedented success of mRNA vaccines during the COVID-19 pandemic has accelerated the development of nucleic acid-based therapeutics, particular...

Short-chain fatty acid-producing microbes differentiate non-infectious and infectious neutropenic fever in leukemia.

UNLABELLED: Neutropenic fever (NF) is often the first sign of infection in patients with hematologic malignancies, but its cause is frequently unknown...

Transformer-based super-resolution lung CT images improve visualization of multiple diseases.

OBJECTIVES: To assess the Transformer-based Swin2SR model for super-resolution (SR) enhancement of lung CT images and its clinical potential. METHODS:...

Neoantigen Targeting as a Novel Approach for Therapy-Resistant Tumors.

Neoantigens have emerged as central targets in the development of individualized cancer vaccines, as they are recognized by the immune system as forei...