Fungal Infection

Improved screening for pulmonary Kaposi sarcoma in a low-resource setting.

OBJECTIVE: The lung is commonly involved in advanced Kaposi sarcoma (KS) but diagnosis of pulmonary KS in low-resource settings is difficult. Clinical assessments were evaluated to improve screening for pulmonary KS in a low-resource setting. METHODS: A longitudinal cohort of Africans with HIV-associated KS in the Parirenyatwa Hospital KS clinic, Harare, Zimbabwe, was followed from 2016 to 2018. A...

Rapid Single-Cell Phenotypic Antifungal Susceptibility Testing on a SlipChip Enabled by Deep Learning.

Fungal infections cause over 1.5 million deaths annually, yet current antifungal susceptibility testing (AFST) methods require 24-48 h, delaying critical treatment decisions. Here, we present a rapid, label-free, single-cell AFST (sc-AFST) platform that integrates a SlipChip microfluidic device with deep learning-based image analysis to determine minimal inhibitory concentrations (MICs) within 4 h...

A multimarker panel for diagnosis and prognosis prediction of fungal infections.

To develop and validate a routine indicator-based multimarker panel for fungal infection (FI) diagnosis and prognosis prediction. A retrospective coho...

Deep learning detection and classification of fungal and non-fungal calcifications on paranasal sinus CT imaging.

This study aimed to develop and evaluate a deep learning algorithm for detecting and classifying intrasinus calcifications on paranasal sinus (PNS) co...

The Macroevolution of Filamentation Morphology Across the Saccharomycotina Yeast Subphylum.

Saccharomycotina are a subphylum of ascomycete fungi with diverse asexual growth morphologies. Filamentous growth can comprise linear and branched bud...

Machine learning-assisted SERS detection of pyrethroid pesticides in edible fungi using a magnetic nanosensor.

Pyrethroid pesticide residues pose a significant global public health challenge, particularly in complex edible fungus matrices where trace, structura...

Grape expectations: disentangling environmental drivers of microbiome establishment in winegrowing ecosystems.

Microbial communities play a central role in viticulture, influencing wine characteristics (a concept termed microbial terroir). Yet, the individual f...

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations.

Candida auris, an increasingly prevalent fungal pathogen, requires both rapid identification and antifungal susceptibility testing to enable proper tr...

Web-Based Sustainable Detection and Treatment Recommendation System for Wheat Plant Diseases Using Convolutional Neural Networks.

Wheat, being a major staple crop worldwide, is often attacked by rust diseases, which cause severe yield losses. The early detection and diagnosis of ...

Non-contact identification of opportunistic pathogens in mixed biofilm contaminations by hyperspectral imaging.

BACKGROUND: Biofilms are present on almost all surfaces in households, healthcare and medical equipment, foods, industrial and water supply systems, a...

α-Helical Peptides Encoded in Collagen Exhibit Antimicrobial Activity with Low Cytotoxicity.

Endogenous antimicrobial peptides (AMPs) derived from host proteins represent a largely underexplored class of natural products tied to innate immunit...

WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield a...

Diagnostic Accuracy of Histopathologic Features Suggestive of Dermatophytosis: A Retrospective Cohort Selection Study With Machine Learning Evaluation.

BACKGROUND: Histopathologic features have been proposed as clues to potential dermatophyte infection. The inter-observer reproducibility and diagnosti...

Soil microbial diversity, stability, and function are enhanced by cover cropping: A machine learning-based pooled analysis of Mississippi agroecosystems.

Cover cropping has emerged as a pivotal strategy to enhance soil health and microbiome functionality across diverse agroecosystems. However, the exten...

Sustainable bioenergy manufacturing in plants.

Sustainable bioenergy is pivotal to the global transition from fossil fuels to a circular bioeconomy. However, conventional biomass conversion remains...

A synthetic biology roadmap for sustainable production of the plant-originated anti-cancer drug paclitaxel.

Paclitaxel, a clinically potent anticancer drug derived from Taxus species, faces persistent challenges in sustainable supply. Synthetic biology prese...

CocoaMoniliaDataSet: A cocoa pod dataset to detect and classify Monilia roreri in real conditions.

Computer vision applications for detecting diseases in agriculture have been gaining relevance in recent years through the use of deep learning archit...

UniSplicer: A deep-learning framework for accurate splice-site prediction and splice-altering mutation detection across diverse taxa.

RNA splicing removes non-coding introns from pre-mRNA to generate mature mRNA in eukaryotes, and accurate identification of splice sites is essential ...

Antimicrobial peptides-based strategies at the frontline in battling the escalating menace of methicillin-resistant Staphylococcus aureus biofilms.

Antimicrobial resistance (AMR), particularly in methicillin-resistant Staphylococcus aureus (MRSA), continues to threaten global health due to its mul...

Harnessing biological control and advanced technologies for sustainable wheat rust management: An integrated approach.

Wheat rusts caused by biotrophic fungi of the genus Puccinia continuously threaten global wheat production and food security. The rapid evolution of v...