Gastroenterology

CLDN18 as a novel junctional biomarker enhancing multi-gene classification of pancreatic cancer.

Pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers, largely due to the lack of ...

Quantifying nonlinear dynamics and key drivers of herd-level milk yield and losses under meteorological and physiological stressors in Holstein cattle.

Meteorological and physiological stressors significantly impair dairy farm productivity and profitab...

Natural language processing for detecting endoscopy-related adverse events in free-text procedure reports at a tertiary referral centre in Türkiye: a 10-year retrospective diagnostic accuracy study.

OBJECTIVES: Automated surveillance of endoscopy-related adverse events (AEs) from non-English free-t...

Author Correction: Machine learning model-guided selective use of temporary diverting ileostomy in rectal cancer surgery: a randomized controlled trial.

Toward a future role for liver biopsy in HCC: literature evidence and survey-based perspectives from Korean experts.

The role of liver biopsy in hepatocellular carcinoma (HCC) is being re-evaluated in the era of preci...

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science.

New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory scie...

PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [68Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.

Lesions with a Prostate Imaging-Reporting and Data System (PI-RADS) score of 4 or greater on multipa...

Therapeutic hybrid intelligence with neural and knowledge-based expert reasoning for SRS (THINKERS): a mixture-of-experts framework for gastrointestinal brain metastases.

BACKGROUND: Brain metastases from gastrointestinal (GI) malignancies are heterogeneous, while stereo...

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer.

IMPORTANCE: Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biologi...

Cough Hypersensitivity in Gastroesophageal Reflux-Induced Chronic Cough: Insights from Reflux Monitoring and High-Resolution Manometry.

BACKGROUND: Cough hypersensitivity contributes to the heterogeneity of gastroesophageal reflux-induc...

From dysbiosis to precision oncology: translational role of the microbiome in gastrointestinal cancer.

Gastrointestinal (GI) cancers, including colorectal, gastric, pancreatic, hepatocellular, and esopha...

Integrating virtual docking and neural network modeling to predict the anti-inflammatory potential of dietary polyphenols in ulcerative colitis.

While the systemic anti-inflammatory benefits of dietary polyphenols are well-established, the speci...

Cost-Effectiveness of AI-Enabled Electrocardiography for Screening MASLD-Associated Advanced Chronic Liver Disease in the US Population.

BACKGROUND: MASLD is the most prevalent chronic liver disease worldwide, with pooled global prevalen...

Predicting Histotripsy Focal Shifts in the Liver From Acoustic Aberrations Using a Deep Learning Model.

OBJECTIVE: To develop a deep learning model for predicting histotripsy focal shifts in the liver cau...

Feasibility of a Stool State Check App Using AI During Bowel Preparation Before Colonoscopy: Multicenter Prospective Study (SCAN Study).

BACKGROUND: Optimal bowel preparation (BP) is crucial for a successful colonoscopy. Although multipl...

Patient-Derived Organoids for Hepatobiliary Cancers: Molecular Mechanisms, Translational Applications and Precision Therapeutics.

Hepatobiliary cancers are highly heterogeneous malignant tumors, and the drug resistance frequently ...

Identification of Primary Sclerosing Cholangitis: ICD-10 Code Validation and Comparison with a Large Language Model Approach.

BACKGROUND: Retrospective studies investigating primary sclerosing cholangitis (PSC) have been limit...

Integrative Multi-Omics Analysis Identifies Thrombosis-Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer.

Emerging evidence indicates that coagulation-related molecular programs are associated with thrombos...

Dedicated Endoscopy for Barrett's Oesophagus With Higher Dysplasia Yield May Reduce Seattle Protocol Biopsies: Results From UK Multicentre Study.

BACKGROUND: Dedicated service for Barrett's oesophagus (BO) surveillance may be more effective than ...

Identification of Pre-Diagnostic Protein Biomarkers for Liver Cirrhosis Based on Prospective Analysis of a Large-Scale Plasma Proteomics in the UK Biobank.

PURPOSE: Liver fibrosis and cirrhosis represent critical stages in the progression of chronic liver ...

The therapeutic potential of saponins for neurological diseases via the gut-brain axis.

Neurological diseases (NDs) constitute a significant threat to global health and impose considerable...