Genetics

Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.

Across the animal kingdom, social behaviors such as aggression are critical for survival and reproductive success. While there is significant variation in social behaviors within and between species, the genetic mechanisms underlying natural variation in social behaviors are poorly understood. A central challenge to investigating the mechanisms contributing to the evolution of social behaviors is ...

Single-cell sequencing combined with transcriptome sequencing to reveal the molecular mechanisms related to integrated stress responses in atherosclerosis.

Adaptive Niching-Based Gradient-Accelerated Differential Evolution for High-Dimensional Nonconvex Optimization.

Nonconvex optimization presents significant challenges in many fields, particularly in training deep neural networks (DNNs), where poor local minima c...

Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL): Protocol for a Prospective Observational Cohort Study.

BACKGROUND: Understanding interindividual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymph...

Future directions in infertility research: the role of generative AI and large language models.

Male infertility remains an understudied yet significant contributor to global reproductive health challenges, with up to 50% of infertility cases inv...

Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling.

BACKGROUND & AIMS: Neural networks constitute a crucial component of the tumor microenvironment that remains underexplored in pancreatic carcinogenesi...

Composite pathway-guided Cox modeling for interpretable survival prediction in breast cancer.

Accurate survival prediction in breast cancer is essential for patient risk stratification and personalized treatment planning. Although transcriptomi...

Twisted Tapestry of Tumors: Updates in Molecular Pathology of Breast Tumors.

This article explores the expanding role of molecular diagnostics in breast pathology. It emphasizes how immunohistochemistry, fluorescence in situ hy...

Generative design of synthetic gene circuits for functional and evolutionary properties.

In the past decades, a wide suite of design tools for biological systems has been developed, but using these to create biotechnologies that achieve re...

scCAPReSE: detection of large-scale genomic rearrangements from single-cell Hi-C based on few-shot learning.

Large-scale genomic rearrangements are prevalent in cancer genomes and can profoundly rewire three-dimensional (3D) genome architecture, leading to ab...

Comprehensive Multiomics Characterization of Perineural Invasion in Cervical Cancer Reveals Diagnostic Markers, Molecular Drivers, and Therapeutic Strategies.

UNLABELLED: Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key in...

Representation learning of single-cell RNA-seq data.

Single-cell RNA sequencing (scRNA-seq) has become a cornerstone experimental technique in tissue biology, with gene expression data for over 100 milli...

Deep learning for RNA secondary structure determination: gauging generalizability and broadening the scope of traditional methods.

The diverse regulatory functions, protein production capacity, and stability of natural and synthetic RNAs are closely tied to their ability to fold i...

Unlocking Enzyme Discovery: A High-Resolution Gene Cluster Database Powered by Phylogenetic Insights and Machine Learning.

High-throughput sequencing has generated vast genomic repositories that remain under-annotated, hampering enzyme discovery. We present an integrated p...

The impact of stability considerations on genetic fine-mapping.

Fine-mapping methods, which aim to identify genetic variants responsible for complex traits following genetic association studies, typically assume th...

Machine Learning Prediction of Progression to Dialysis in Patients With Polycystic Kidney Disease: Population-Based Retrospective Cohort Study.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst growth and renal decline, is the leading genetic c...

Advances in the laboratory diagnosis of non-viral microbial keratitis.

Infectious keratitis remains a leading cause of corneal blindness and visual impairment worldwide, with bacterial, fungal, amoebic and viral pathogens...

Drug repurposing in oncology: Bridging computational discovery to clinical application.

Drug repurposing, the identification of new therapeutic applications for existing drugs, has emerged as a pragmatic and cost-efficient strategy to acc...

Experimental investigation of muscle-tendon unit geometry and kinematics in lower-limb muscles during gait: Current applications and future directions - A scoping review.

PURPOSE: Musculoskeletal (MSK) modeling and ultrasound imaging (USI) are complementary techniques that, when combined with three-dimensional gait anal...

Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.

Disruptions in chromatin remodelers and synaptic proteins represent major genetic risk factors for autism spectrum disorder (ASD), yet how these disti...