Latest AI and machine learning research in genetics for healthcare professionals.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder increasingly associated with peripheral inflammatory conditions such as chronic periodontitis (CP); however, the molecular mechanisms linking these conditions remain poorly understood. Here, we investigated the therapeutic effects of Huanglian Jieddu Decoction (HLJDD) on CP-induced AD using an integrative machine learning-guided ...
The genus Delphinium exemplifies the complexity of plant diversification in mountainous regions, where rapid speciation, hybridization, and morphological convergence frequently obscure species boundaries. The North American lineage Delphinium sect. Diedropetala has rapidly radiated across a range of ecological habitats, from alpine tundra to desert grasslands, forming an iconic component of wester...
BACKGROUND: High-frequency recurrence (HfR, ≥ 2 recurrences) in non-muscle-invasive bladder cancer (NMIBC) poses a significant clinical burden. Curren...
Immune checkpoint inhibitors (ICIs) have transformed the advanced melanoma treatment landscape; however, a subset of patients achieve durable response...
BACKGROUND: Acute lung injury (ALI) involves the release of growth factors and inflammatory mediators from damaged pulmonary tissues, fostering endoth...
BACKGROUND: NSCLC remains one of the leading causes of death from cancer worldwide. Although brain metastases are indeed common and also a significant...
Mesenchymal stromal cells (MSCs) possess potent immunomodulatory, pro-angiogenic, and regenerative capacities, offering broad clinical promise in rege...
Bruton tyrosine kinase (BTK) is a non-receptor tyrosine kinase crucial for relaying signals from the B cell antigen receptor (BCR) in cancerous B lymp...
PURPOSE: To replicate previously reported genetic associations for the retinal aging clock-quantified as the retinal age gap-in an East Asian populati...
BACKGROUND: Scleral extracellular matrix (ECM) remodeling plays a key role in myopia development. This study aims to identify ECM stiffness-related ge...
BACKGROUND: Emerging evidence indicates that SARS-CoV-2 infection is associated with aging, particularly in memory-related domains. However, the molec...
Advances in computational biology are reshaping enzyme engineering from empirical practice into a predictive, model-driven discipline. Traditional str...
Predicting spatial gene expression from Histological images is a fundamental task in understanding tissue organization and molecular phenotypes. Howev...
Exosomes are nanosized extracellular vesicles enriched with proteins, lipids, and nucleic acids and are emerging as powerful mediators of intercellula...
Recent advances in Artificial Intelligence (AI) are reshaping kinase research by uncovering complex regulatory mechanisms and accelerating drug discov...
The precise identification of cancer driver mutations is essential for precision oncology; however, it remains a significant challenge because of the ...
BACKGROUND: Immune checkpoint blockade (ICB) therapy has provided a promising treatment option for patients with triple-negative breast cancer (TNBC)....
BACKGROUND: Atrial cardiopathy often precedes atrial fibrillation (AF) and has emerged as an independent risk factor for cardiovascular outcomes. Howe...
MOTIVATION: Clustering single-cell RNA sequencing (scRNA-seq) data plays a vital role in the study of cellular heterogeneity. Many algorithms have bee...
BACKGROUND AIMS: Pathological complete response (pCR) following conversion therapy for initially unresectable hepatocellular carcinoma (uHCC) remains ...