Latest AI and machine learning research in genetics for healthcare professionals.
Histone deacetylase 8 (HDAC8), a pivotal epigenetic regulator orchestrating chromatin remodeling and transcriptional control, has emerged as a compelling anticancer target owing to its frequent dysregulation in malignancies. The development of isoform-selective inhibitors, however, confronts substantial challenges because of the pronounced structural conservation across HDAC isoforms. This study d...
Brain metastasis remains a lethal clinical challenge, largely driven by dormant tumour cells (DTCs). This reversible quiescent state enables disseminated cancer cells to evade conventional therapies and eventually cause relapse. This review provides an in-depth overview of the mechanisms through which the unique brain microenvironment orchestrates the dormancy plasticity. We summarize the multicel...
BACKGROUND: Most radiogenomic studies examine single driver mutations in isolation, despite evidence that co-occurring driver alterations are common a...
Genomic reanalysis can identify causative variants for rare diseases as patient phenotypes evolve and gene-disease knowledge expands. Despite its diag...
Natural biological systems achieve precise cellular control through multidimensional signaling architectures that integrate sequence specificity, stru...
Accurate detection of insertions and deletions (indels) is critical for applications in disease genomics, population genetics, and personalized health...
Lipid nanoparticle (LNP)-mRNA technology has profoundly transformed the biomedical landscape, establishing itself as a highly versatile and powerful p...
Methane production from wastewater sludge via anaerobic digestion is a complex process and a disturbance in any one of the microbial stages can lead t...
BACKGROUND: Glioblastoma (GBM) is a highly aggressive form of brain tumor with poor prognosis. This study aimed to identify genes critical to glioma d...
Bisphenol A (BPA), a common industrial chemical and endocrine disruptor, poses serious health risks, highlighting the need for sensitive detection met...
Monoclonal gammopathies span a continuum from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to overt...
Sjögren's Syndrome (SS) is a long-term autoimmune disorder marked by damage to exocrine glands and irregularities in the immune system. Currently, the...
The rich information encoded in cis-regulatory DNA sequences has not been fully exploited for gene function prediction in reverse genetics. Here we sh...
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health concern, especially due to multi-drug resistance. Resistance of...
PURPOSE OF REVIEW: Emerging biobank resources allow large-scale integration of eye-specific phenotypes with clinical, genomic, and multiomic data. Thi...
BACKGROUND: Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, ultimately progressing to heart failure and inc...
Tobacco smoke contains a complex array of genotoxic carcinogens that form structurally diverse DNA adducts, driving mutagenesis and carcinogenesis. Am...
Parkinson's disease (PD) risk and progression are influenced by a complex interplay of genetic, environmental, and internal factors. Environmental exp...
BACKGROUND AND OBJECTIVE: Most prostate cancer prevention strategies suggest lifestyle modifications, which lack personalization. Gut microbiome is in...
Fine-grained prediction of chromatin accessibility from DNA sequence is a foundational step in modeling gene expression changes resulting from sequenc...