Latest AI and machine learning research in genetics for healthcare professionals.
Intestinal parasitic infections (IPIs) have a worldwide distribution and have a major impact on health, work capacity, and economy in many countries. Light microscopy is still considered the reference method for IPI diagnosis but is labor-intensive. KU-F40, an automated feces analyzer, combines automated microscopic examination of stool samples and deep learning artificial intelligence. The aim of...
Intracranial aneurysms (IAs) are severe cerebrovascular disorders lacking effective gene therapy or pharmacological interventions. Vascular smooth muscle cell (VSMC) senescence has been associated with various cardiovascular and cerebrovascular diseases; however, its role in IA pathogenesis remains unexplored, and the key regulatory genes remain unidentified. By integrating multi-omics data, machi...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent mucosal inflammation. While fibroblasts contribute to tiss...
Accurate prediction of gene expression levels across different tissues is of great significance in understanding the functional roles of genes in vari...
Congenital heart disease (CHD) is a major cause of infant mortality and presents life-long challenges to individuals living with these conditions. Gen...
The occurrence and development of a wide range of preeclampsia (PE), especially early-onset preeclampsia (EOPE), is closely associated with the immune...
Homologous recombination deficiency (HRD) can lead to genomic instability, increased cancer susceptibility, and enhanced sensitivity to DNA-targeting ...
Diethyl phthalate (DEP) is a ubiquitous environmental endocrine-disrupting chemical (EDC). Epidemiological studies have suggested a potential associat...
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumor with poor clinical outcomes. Accumulated evidence has demon...
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a frequently encountered respiratory disease. Its clinical symptoms ar...
BACKGROUND: Liver fibrosis and acute myocardial infarction (AMI) tended to co-occur. Cellular senescence and an imbalanced immune microenvironment wer...
The paramount challenge in precision oncology lies in further improving quality of life and response rates for individual patients. Efforts toward the...
BACKGROUND: Cytomegalovirus (CMV) End-Organ Disease (EOD) remains a significant complication in immunocompromised individuals, particularly transplant...
Preeclampsia (PE) is a multifactorial and heterogeneous hypertensive disorder of pregnancy that poses significant diagnostic and therapeutic challenge...
The tumor immune microenvironment and intratumoral microbiota play critical roles in cancer progression and immunotherapy response, yet their integrat...
PURPOSE: Soft tissue tumors (STT) are highly heterogeneous neoplasms with more than 100 recognized subtypes, many of which lack reliable diagnostic or...
Colorectal cancer (CRC) is the third most common malignancy worldwide, and early detection is vital to prevent metastasis and postoperative recurrence...
The epitranscriptome comprises chemical modifications found on RNA molecules that play essential roles in co- and post-transcriptional gene regulation...
With the rapid growth of the volume of image data, the burden of storage and transmission has increased dramatically. However, current algorithms face...
Spatial transcriptomics is an emerging technology that can analyze gene expression profiles of tissues while preserving spatial location information. ...