Latest AI and machine learning research in genetics for healthcare professionals.
Modern biobanks are providing numerous high-resolution genomic sequences of diverse populations. In order to account for diverse and admixed populations, new algorithmic tools are needed in order to properly capture the genetic composition of populations. Here, we explore deep learning techniques, namely, variational autoencoders (VAEs), to process genomic data from a population perspective. We sh...
Acute myeloid leukemia (AML) is a clinically aggressive hematologic malignancy driven by complex genetic and epigenetic aberrations. Circular RNAs (circRNAs), characterized by covalently closed structures and exceptional stability, have emerged as promising diagnostic biomarkers. However, existing circRNA-based predictive models largely depend on differential expression, overlooking the potential ...
Fanconi anemia (FA) is an inherited bone marrow failure syndrome with cancer predisposition. Most FA patients develop aplastic anemia during childhood...
BACKGROUND: Staphylococcus aureus (S. aureus) pneumonia constitutes a lethal respiratory infection with persistently high clinical mortality. Although...
Semantic code clone detection plays an essential role in software maintenance and quality assurance, as it helps uncover fragments of code that expres...
Enhancing enzyme thermostability is crucial for industrial applications requiring robust performance under extreme conditions. Structure-based protein...
PURPOSE OF REVIEW: The early-life gut microbiome is a dynamic ecosystem that alongside other niches, such as the oral and skin microbiomes, undergoes ...
Phlorotannins, bromophenols, sulfated polysaccharides, terpenoids, lipids and halogenated molecules exhibit potent antioxidant, anticancer, anti-infla...
Lateral flow assays (LFAs) have garnered much interest in the biomedical and agricultural sciences because of their user-friendly design, quick turnar...
Saccharomycotina are a subphylum of ascomycete fungi with diverse asexual growth morphologies. Filamentous growth can comprise linear and branched bud...
BACKGROUND: Oxford Nanopore Technologies (Oxford Nanopore Technologies (ONT)) sequencing enables direct, long-read sequencing of DNA and RNA, preservi...
AIMS: Proliferation of arterial smooth muscle cells (SMCs) and their modulation to alternative mesenchymal phenotypes is central to atherosclerotic le...
Huntington's disease (HD) is a rare, inherited neurodegenerative disorder caused by the expanded CAG repeats in the huntingtin gene. The HD domain sti...
Esophageal squamous cell carcinoma (ESCC) remains a leading cause of cancer-related mortality, with early detection being challenging. Although endosc...
Following their success in natural language processing and protein biology, pretrained large language models have started appearing in genomics in lar...
BACKGROUND: Accurate preoperative staging is critical for improving the prognosis, treatment, and survival outcomes of epithelial ovarian cancer (EOC)...
BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy originating from the epithelial lining of second-order bile ducts. Desp...
Accurate classification of hematopoietic cancer subtypes remains challenging due to the multipotent nature of hematopoietic cells and the absence of d...
BACKGROUND: Being involved in the occurrence of colorectal cancer (CRC), gut microbes are potential targets for early diagnosis of CRC. Defining the t...
Stroke, a result of acute cerebrovascular disease that causes cerebral dysfunction, often coexists with depression or even major depressive disorder (...