Genetics

Genomic and machine learning approaches to predict antimicrobial resistance in .

UNLABELLED: is a multidrug-resistant pathogen, which poses a major challenge to clinical management due to its increasing resistance to common antibiotics, such as levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT), and poor clinical response to treatment. There is an urgent need for rapid and reliable antimicrobial susceptibility testing (AST) methods to improve treatment outcomes. This ...

Divergence in a eukaryotic transcription factor's co-TF dependence involves multiple intrinsically disordered regions.

Combinatorial control by transcription factors (TFs) is central to eukaryotic gene regulation, yet its mechanism, evolution, and regulatory impact are not well understood. Here we use natural variation in the yeast phosphate starvation (PHO) response to examine the genetic basis and species variation in TF interdependence. In Saccharomyces cerevisiae, the main TF Pho4 relies on the co-TF Pho2 to r...

In vivo mapping of mutagenesis sensitivity of human enhancers.

Distant-acting enhancers are central to human development. However, our limited understanding of their functional sequence features prevents the inter...

Association of DNA methylation epigenetic markers with all-cause mortality and cardiovascular disease-related mortality in diabetic population: a machine learning-based retrospective cohort study.

BACKGROUND: Diabetes has a large and diverse population, with individuals exhibiting significant heterogeneity in the disease. The factors influencing...

Comprehensive framework for thyroid disorder diagnosis: Integrating advanced feature selection, genetic algorithms, and machine learning for enhanced accuracy and other performance matrices.

Thyroid hormones control crucial physiological activities, such as metabolism, oxidative stress, erythropoiesis, thermoregulation, and organ developme...

Morphological traits and machine learning for genetic lineage prediction of two reef-building corals.

Integrating multiple lines of evidence that support molecular taxonomy analysis has proven to be a robust method for species delimitation in scleracti...

Coordinated Residue Motions at the Enzyme-Substrate Interface Promote DNA Translocation in Polymerases.

The translocation of DNA in polymerase (Pol) enzymes is a critical step for Pol-mediated nucleic acid polymerization, essential for storing and transm...

Early detection and staging of retinitis pigmentosa using multifocal electroretinogram parameters and machine learning algorithms.

Retinitis pigmentosa is an inherited retinal disease caused by damage to photoreceptor cells. Diagnosis and staging of this disease are crucial for ea...

Genome-wide annotation and comparative analysis of miniature inverted-repeat transposable elements (MITEs) in six pear species.

Through multi-faceted comparative analysis of MITEs across six pear genomes, we revealed their distribution patterns, functional impacts and their sig...

The role of tumor microenvironment and immune cell crosstalk in triple-negative breast cancer (TNBC): Emerging therapeutic opportunities.

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by its lack of estrogen, progesterone, and HER2 receptors, leading to limi...

Investigating the potential risk of cadmium exposure on Osteoporosis: An integrated multi-omics approach.

Osteoporosis (OP) is a chronic progressive bone disease, and its occurrence and development under cadmium exposure remain unclear. This study aims to ...

Optimizing stroke detection with genetic algorithm-based feature selection in deep learning models.

Brain stroke is a leading cause of disability and mortality worldwide, necessitating the development of accurate and efficient diagnostic models. In t...

Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine.

DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation...

Stereotactic Body Radiation Therapy for Primary Renal Cancer and Genetic Markers of Response: A Phase 2 Trial.

Controlled outcome assessment of radiotherapy for primary renal cell carcinoma (RCC) remains limited, particularly regarding its impact on ipsilateral...

Advanced molecular approaches to thalassemia disorder and the selection of molecular-level diagnostic testing in resource-limited settings.

Beta-thalassemia is a genetic disorder that significantly burdens healthcare systems globally. This inherited blood disorder, categorized into beta-th...

In vitro processes alter the embryonic disc epigenome and transcriptome in the pre-implantation elongated bovine embryo†.

The objective was to quantify the effect of the in vitro procedures on the epigenome and transcriptome of the embryonic disc (ED) and extra-embryonic ...

Trade-off between resistance and persistence in high cell density cultures.

Bacterial growth to high cell densities is commonly observed in infections, microbiomes, and biomanufacturing, yet there is limited understanding of h...

An Efficient Deep Learning Framework for Revealing the Evolution of Characterization Methods in Nanoscience.

Text mining has emerged as a powerful strategy for extracting domain knowledge structure from large amounts of text data. To date, most text mining me...

Data Fusion for Integrative Species Identification Using Deep Learning.

DNA analyses have revolutionized species identification and taxonomic work. Yet, persistent challenges arise from little differentiation among and con...

Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting.

The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance ...