Genetics

DNA forensics at forty: the way forward.

Forensic DNA analysis has transformed criminal investigations since its inception in 1985. Over four decades, this field has evolved through various phases-from the early stages of exploration to today's highly sophisticated methodologies. Key advancements such as the development of rapid DNA analysis techniques, microchip-based systems, and next-generation sequencing have improved the speed, reli...

Transcriptomic signatures of rare variant impacts across sex and the X chromosome.

The human X chromosome contains hundreds of genes and has well-established impacts on sex differences and traits. However, the X chromosome is often excluded from many genetic analyses, limiting broader understanding of variant effects. In particular, the functional impact of rare variants on the X chromosome is understudied. To investigate functional rare variants on the X chromosome, we use obse...

Development and interpretation of a pathomics-based model for the prediction of immune therapy response in colorectal cancer.

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide, with a 5-year survival ra...

: Enhancer Discovery from Human to Fly via Interpretable Deep Learning.

Enhancers are essential non-coding DNA elements that regulate gene expression, yet their accurate identification remains a major challenge. We introdu...

Melting Profile of DNA in Crowded Solution: Model-Based Study.

Recent advances in molecular dynamics (MD) simulations and the introduction of artificial intelligence (AI) have resulted in a significant increase in...

Prediction of Lymph Node Metastasis in Non-Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data.

PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnosti...

Multi-Omics-Based Characterization of DNA Methylation Episignatures for Papillary Thyroid Cancer in a Chinese Population.

Thyroid cancer is the most common endocrine malignancy, with papillary thyroid cancer (PTC) accounting for ∼80% of all cases. DNA methylation alterat...

Revolutionizing breast cancer immunotherapy by integrating AI and nanotechnology approaches: review of current applications and future directions.

Breast cancer (BC) is still the most diagnosed cancer for females with an increased focus on immunotherapy as a promising precise treatment. Selecting...

Hyperspectral Imaging for Rapid Detection of Common Infected Bacteria Based on Fluorescence Effect.

The rapid and accurate detection of bacterial infections in wounds is crucial for clinical diagnosis. Traditional methods, such as bacterial culture a...

Integrated Single-Cell and Bulk RNA Sequencing Analysis Identifies a Regulated Cell Death-Related Gene Signature for Predicting Prognosis and Therapeutic Responses in Cutaneous Melanoma.

Regulated cell death (RCD) is crucial for the advancement of cancers, and providing opportunities as prognostic indicators and immunotherapy markers f...

Unraveling senescence in cancer: mechanistic complexities and therapeutic opportunities.

Senescence is a pivotal cellular process, which also plays a major role in development, immune regulation, tissue repair, and aging, triggered by stre...

Development of an immune scoring system based on exosome-related gene expression for prognosis and treatment response prediction in breast cancer.

Breast cancer (BC) is a heterogeneous disease with diverse subtypes that influence prognosis and treatment outcomes. While advances have been made in ...

Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, w...

A review of enhanced biosignature immunotherapy tools for predicting lung cancer immune phenotypes using deep learning.

Cancer has increasingly been recognized as a genetic disease, influenced by lifestyle changes, dietary patterns, and environmental pollutants. Lung ca...

Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety.

BACKGROUND: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxie...

Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay.

BACKGROUND: Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human p...

A solution to the postantibiotic era: phages as precision medicine.

Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics th...

Strategies for Treatment De-escalation in Metastatic Renal Cell Carcinoma.

Immune checkpoint inhibitors (ICIs) and targeted therapies have revolutionized the management of metastatic renal cell carcinoma (mRCC). Currently, th...

Integrative strategies in drug discovery: Harnessing genomics, deep learning, and computer-aided drug design.

The development of novel drugs increasingly relies on advanced omics technologies, including genomics, transcriptomics, proteomics, and metabolomics. ...

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening.

INTRODUCTION: Data-driven omics approaches have rapidly advanced our understanding of the molecular heterogeneity of Alzheimer's disease (AD). However...