Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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In vitro processes alter the embryonic disc epigenome and transcriptome in the pre-implantation elongated bovine embryo†.

The objective was to quantify the effect of the in vitro procedures on the epigenome and transcripto...

Generative prediction of causal gene sets responsible for complex traits.

The relationship between genotype and phenotype remains an outstanding question for organism-level t...

Toward a general framework for AI-enabled prediction in crop improvement.

A theoretical framework for AI and ensembled prediction for crop improvement is introduced and demon...

Incorporating automation in a cytogenetics laboratory: three practitioners' perspectives on benefits and limitations.

Automation has been developed and continues to be refined for cytogenetics, including advances in th...

MPSE identifies newborns for whole genome sequencing within 48 h of NICU admission.

Identifying critically ill newborns who will benefit from whole genome sequencing (WGS) is difficult...

A Trust-Region Projection Neural Network for Nonlinear Programming.

The trust-region method and projection neural networks are two branches of optimization approaches w...

Exploring the molecular mechanisms of lactylation-related biological functions and immune regulation in sepsis-associated acute kidney injury.

Lactylation, a novel post-translational modification, has been implicated in various pathophysiologi...

Rapid prediction of antibiotic resistance in complex using whole-genome and metagenomic sequencing.

Clinical management and surveillance of the complex (ECC) face significant challenges due to inaccu...

RNAS-sgRNA: Recurrent Neural Architecture Search for Detection of On-Target Effects in Single Guide RNA.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 is a leading genomic editing...

Integrative machine learning reveals the biological function and prognostic significance of α-ketoglutarate in gastric cancer.

Gastric cancer (GC) has a poor response to treatment, an unfavorable prognosis and a lack of reliabl...

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state.

Amyloid aggregates are pathological hallmarks of many human diseases, but how soluble proteins nucle...

Enhancing R-loop prediction with high-throughput sequencing data.

R-loops are three-stranded RNA and DNA hybrid structures that often occur in the genome and play imp...

Updates on inherited arrhythmia syndromes (Brugada syndrome, long QT syndrome, CPVT, ARVC).

The inherited arrhythmia (IA) syndromes are a group of rare and complex conditions that may predispo...

OptimDase: An Algorithm for Predicting DNA Binding Sites with Combined Feature Encoding.

Identifying DNA binding sites remains a critical task in bioinformatics, with applications ranging f...

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