Genetics

Genetically predicted breastfeeding propensity and brain microstructural morphology: Insights from genome-wide association study summary statistics and neurogenomics.

BACKGROUND: Breastfeeding provides nutrients and bioactive components relevant to infant development, but observational associations with brain outcomes may be influenced by socioeconomic, maternal, and family-level factors. Mendelian randomization (MR) offers a genetic framework for evaluating associations by using genetic variants as proxies for breastfeeding propensity; it does not directly mea...

Retinal Pigment Epithelium and Microglia Transplantation in Age-related Macular Degeneration.

Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, characterized by the progressive breakdown of the outer blood-retinal barrier, accumulation of protein and lipid deposits in the subretinal space, and the consequential degeneration of macular photoreceptors. Geographic atrophy (GA) is one of the blinding end points of AMD. While current pharmaceuti...

The single-cell atlas of programmed cell death signature: A machine learning-based prognostic framework in breast cancer.

Breast cancer remains a leading cause of cancer-related mortality in women, and current prognostic models are suboptimal. The transcriptomic role of p...

Systems-level genomic analyses reveal shared mechanisms underlying endometriosis and sleep disorders.

We examined clinical, genetic, and molecular links between sleep disorders and endometriosis. Women aged 20-54 years in NHANES 2005-2006 were analyzed...

Molecular mechanisms of phytochemicals from Zanthoxylum nitidum (Roxb.) DC. against hepatocellular carcinoma: insights from network pharmacology, molecular docking, and bioinformatics.

Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited therapies. We explored the anti-HCC mechanisms of Zanthoxylum nitidum (Roxb.) ...

Integrating network pharmacology, machine learning, and molecular docking to explore the therapeutic mechanisms of Huangqin in atopic dermatitis: A STROBE-compliant observational study.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder with complex pathogenesis, and current therapies face limitations in efficacy and safet...

UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling.

Systematically simulating and predicting phenotypic effects of diverse interventions across heterogeneous cellular environments is central to the visi...

Modern approaches to gut microbiome investigation: Sequencing, culturomics, metabolomics, and beyond.

The human gut microbiome is a complex and constantly evolving community of trillions of microorganisms that are crucial to various aspects of health a...

Global genomic surveillance of β-lactam resistance in Escherichia coli across human, animal, and environmental reservoirs.

BACKGROUND: Escherichia coli poses a global health threat from increasing β-lactam resistance. This study uses genomic and One-Health data to map resi...

AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial.

The accurate and timely diagnosis of inherited retinal diseases (IRDs) represents an unmet clinical need in ophthalmology, as the current pathways rel...

Epigenomics-Guided Multi-Omics Integration Uncovers a Lipid-Metabolic Signature with Translational Utility in Bladder Cancer.

Background: Bladder cancer (BLCA) exhibits marked heterogeneity, and current classifiers provide limited guidance for prognosis or treatment. Because ...

Classifying Diabetic and Healthy β-Cells in Type 2 Diabetes Using Machine Learning on Single-Cell RNA Sequencing Data.

Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms...

Research advances in key genes and regulatory mechanisms of posttranslational modifications in Parkinson's disease.

BACKGROUND: The genesis of Parkinson's disease (PD), a common central neurodegenerative disorder, involves dysregulation of protein posttranslational ...

Fundus image analysis of retinitis pigmentosa using artificial intelligence.

Retinitis pigmentosa (RP) is a group of inherited retinal diseases that are caused by genetic defects that lead to progressive photoreceptor loss and ...

Systematic Position Mapping of Split CRISPR-Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification.

Amplification-free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activat...

A culturally transmitted foraging technique in Indo-Pacific bottlenose dolphins can be predicted by DNA-methylation levels.

Cultural repertoires can influence access to resources and fitness across species, impacting individuals' environmental niches and social networks. Su...

Inferences from epigenetic information in an ecological context: a case study of early-life environmental effects on DNA methylation in zebra finches.

DNA methylation (DNAm) plays a key role in mediating phenotypic responses to environmental variation. Various approaches exist to link DNAm variation ...

Integrative multi-omics reveals NQO1-mediated airway epithelial injury as a key mechanism of bisphenol A-induced COPD.

Bisphenol A (BPA) is a ubiquitous environmental pollutant, but its relationship with chronic obstructive pulmonary disease (COPD) and the underlying t...

Multi-omics and genetic prioritization identify candidate molecular links between micro- and nanoplastics-associated signatures and chronic kidney disease.

Micro- and nanoplastics (MNPs) have been detected in human renal and urinary tissues and are increasingly recognized as potential environmental contri...

Zebrafish as a versatile model in biomedical research, from disease modeling to regenerative medicine: a review.

Zebrafish are an effective animal model widely utilized in biomedical research. They are known for their rapid reproduction and substantial genetic si...