Genetics

Radiomics for predicting microsatellite instability-high status in colorectal cancer: a systematic review and meta-analysis.

OBJECTIVE: Microsatellite instability (MSI) has emerged as a key predictive biomarker for chemothera...

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment.

Base editors enable precise genome modification and have emerged as a promising therapeutic approach...

Deep Learning for Survival Prediction in Glioblastoma: Time-dependent Model Interpretability Using MRI, Clinical, and Molecular Data.

Purpose To develop a multimodal model for survival prediction and time-dependent model interpretabil...

Radiomics-based outcome prediction for irinotecan-TACE in colorectal liver metastases: advanced analysis from the prospective CIREL trial.

OBJECTIVES: Transarterial chemoembolization (TACE) is a promising locoregional therapy for unresecta...

SPACESHIP: Autonomous Mapping of Hardware-Dependent Synthesizable Space in Solution-Phase Gold Nanomaterials.

Autonomous laboratories hold great promise for accelerating materials discovery but often inherit hi...

Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.

Most genetic variants in the human genome reside in non-coding regions, where they can perturb regul...

scDecorr: feature decorrelation based representation learning enables self-supervised alignment of multiple single-cell experiments.

Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneit...

Construction and validation of a glycosylation-related diagnostic model and immune characterization in lupus nephritis.

BACKGROUND: As a critical hallmark of systemic lupus erythematosus, lupus nephritis (LN) stands as a...

Temporal dynamics and stability of the human microbiome for forensic individual identification.

The human microbiome is ubiquitous across nearly all body sites and exhibits biological characterist...

The Role of Molecular Testing in Head and Neck Squamous Cell Carcinoma of Unknown Primary.

Squamous cell carcinomas of unknown primary (SCCUP), accounting for approximately 5% of head and nec...

Divide-and-conquer analysis reveals hidden immune cell influencers across the placenta in preeclampsia.

BACKGROUND: Placenta is a focal point of cellular interactions of maternal and fetal immune systems,...

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study.

Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamid...

Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives.

Circulating miR-10b-5p as a Candidate Biomarker of Atrial Fibrillation Recurrence After Catheter Ablation: A Two-Phase Translational Study.

BACKGROUND: The identification of reliable biomarkers for atrial fibrillation (AF) recurrence post-c...

Precision Medicine in Autoimmune Thyroid Diseases: Decoding Biomarkers, Targeted Therapies and Digital Innovation.

INTRODUCTION: Autoimmune thyroid diseases (AITDs), including Graves' disease and Hashimoto's thyroid...

Integrating single-cell and bulk transcriptomes to reveal prognostic and immunological features of ecDNA-related genes in osteosarcoma.

BACKGROUND: The role of extrachromosomal DNA (ecDNA)-related genes in osteosarcoma remains largely u...

CASER: A semi-supervised model with multi-omics data integration prioritizes cancer-associated epigenetic regulator genes.

Prioritizing a reliable list of cancer-associated epigenetic regulators (cERs) is critical for cance...

Predicting Peptide Aggregation with Protein Language Model Embeddings.

Amyloid fibrils, a form of peptide aggregates, are associated with multiple diseases and hinder the ...

Pleiotropic germline PTEN mutations influence gastrulation through dysregulated AKT activation.

PTEN hamartoma tumor syndrome (PHTS), caused by germline PTEN mutations, exhibits pleiotropic manife...

Ion correlations explain kinetic selectivity in diffusion-limited solid-state synthesis reactions.

Establishing viable solid-state synthesis pathways for novel inorganic materials remains a major cha...

A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.

Lipid nanoparticle (LNP) delivery of RNA therapeutics is constrained by poor tissue selectivity and ...