Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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A Large-Scale Cryo-EM RNA Motif Dataset and Benchmark for Machine Learning-Based Structure Modeling

Motivation: RNA molecules play critical roles in gene regulation, viral replication, and cellular co...

HiCInterpolate: 4D Spatiotemporal Interpolation of Hi-C Data for Genome Architecture Analysis.

Motivation: Studying the three-dimensional (3D) structure of a genome, including chromatin loops and...

seq2ribo: Structure-aware integration of machine learning and simulation to predict ribosome location profiles from RNA sequences

Motivation: Ribosome dynamics are vital in the process of protein expression. Current methods rely o...

Preserved Embedding of Neural Population Activity for Brain Computer Interfaces

Inferring stable neural representations of motor cortical dynamics is essential for brain-computer i...

Designing AI-programmable therapeutics with the EDEN family of foundation models

The ability to interpret, modify, and design DNA has driven many of the most significant advances in...

A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue

Perivascular adipose tissue (PVAT), an intriguing layer of fat surrounding blood vessels, regulates ...

Central Dogma Transformer II: An AI Microscope for Understanding Cellular Regulatory Mechanisms

Current biological AI models lack interpretability -- their internal representations do not correspo...

Identification of Novel mRNA Biomarkers with Improved Performance for Colorectal Cancer Screening from a Multicenter Large Gene Screen

Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer mortality. While early det...

Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse Brain

Histone modifications underpin the cell-type-specific gene regulatory networks that drive the remark...

Characterizing yield through wheat's perception of chronological progression: a multi-omics plant-time warping approach

To address challenges in food security, a better understanding of crop performance under varying and...

Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species

Pseudouridine ({Psi}) modifications are the most abundant RNA modifications; however, their distribu...

Accelerating Vision Transformers on Brain Processing Unit

With the advancement of deep learning technologies, specialized neural processing hardware such as B...

Universal Anti-forensics Attack against Image Forgery Detection via Multi-modal Guidance

The rapid advancement of AI-Generated Content (AIGC) technologies poses significant challenges for a...

RAIGen: Rare Attribute Identification in Text-to-Image Generative Models

Text-to-image diffusion models achieve impressive generation quality but inherit and amplify trainin...

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer's disease

Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer'...

Delphi: Deep Learning for Polygenic Risk Prediction

Polygenic scores (PGS) are relative measures of an individual's genetic propensity to a particular t...

Practical utility of sequence-to-omics models for improving the reproducibility of genetic fine-mapping

Recent advances in deep learning have led to the development of sequence-to-omics (S2O) models that ...

Mapping trans-eQTLs at single-cell resolution using Latent Interaction Variational Inference.

Single-cell expression quantitative trait loci (eQTL) studies hold promise for linking genetic varia...

Unified imputation of missing data modalities and features in multi-omic data via shared representation learning

Multi-omic studies promise a more comprehensive view of biological systems by jointly measuring mult...

Predictive Modeling of COVID-19 Variant Peak Prevalence and Duration Using GISAID Data Across 15 Countries

BackgroundRapid emergence and replacement of SARS-CoV-2 variants underscore the need for early and r...

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