Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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DOGMA: Weaving Structural Information into Data-centric Single-cell Transcriptomics Analysis

Recently, data-centric AI methodology has been a dominant paradigm in single-cell transcriptomics an...

Rethinking Genomic Modeling Through Optical Character Recognition

Recent genomic foundation models largely adopt large language model architectures that treat DNA as ...

OLion: Approaching the Hadamard Ideal by Intersecting Spectral and $\ell_{\infty}$ Implicit Biases

Many optimizers can be interpreted as steepest-descent methods under norm-induced geometries, and th...

Toward Interpretable and Generalizable AI in Regulatory Genomics

Deciphering how DNA sequence encodes gene regulation remains a central challenge in biology. Advance...

Rectifying Stress into Structural Memory Drives Specialization in Cells and Adaptive Computational Systems

Functional specialization in continuous systems requires balancing adaptation to environmental stres...

Ab initio prediction of RNA structure ensembles with RNAnneal

RNA utilizes three-dimensional structure in addition to sequence to carry out diverse functions in g...

An AI-Native Biofoundry for Autonomous Enzyme Engineering: Integrating Active Learning with Automated Experimentation

The engineering of enzymes with novel functions is a cornerstone of synthetic biology but remains bo...

An AI-Integrated Framework for Precision Genomics in Coronary Artery Disease Using Whole Exome and Phenotypic Data

Coronary artery disease (CAD) is a multifactorial condition influenced by genetic, phenotypic, and e...

Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune-related GWAS loci in CD4+ T cells

Functional interpretation is essential for understanding how genetic variants contribute to complex ...

Diversity of antibiotic resistance genes increases in urbanized lakes: a multi-tool screening

Antimicrobial resistance (AMR) is a growing global public health threat projected to cause up to 10 ...

DVPNet: A New XAI-Based Interpretable Genetic Profiling Framework Using Nucleotide Transformer and Probabilistic Circuits

This research provides an XAI-driven genetic profiling approach that may contribute to scientific di...

A systematic assessment of machine learning for structural variant filtering

Background: Accurate discrimination of true structural variants (SVs) from artifacts in long-read se...

Longevity Bench: Are SotA LLMs ready for aging research?

Aging is a core biological process observed in most species and tissues, which is studied with a vas...

Synthetic Abundance Maps for Unsupervised Super-Resolution of Hyperspectral Remote Sensing Images

Hyperspectral single image super-resolution (HS-SISR) aims to enhance the spatial resolution of hype...

Classification of SARS-CoV-2 Variants through The Epistatical Circos Plots with Convolutional Neural Networks

The COVID-19 pandemic has profoundly affected global health, driven by the remarkable transmissibili...

HistoPrism: Unlocking Functional Pathway Analysis from Pan-Cancer Histology via Gene Expression Prediction

Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible al...

Multi-omic deep learning identifies exercise-responsive ageing pathways in humans

Genome-wide association studies of physical activity traits have mapped numerous loci, yet the molec...

Gene-centered representation of coding and regulatory variation enables outcome prediction

Integrating coding and regulatory variation into unified, interpretable representations remains a ch...

Functional In-Context Learning in Genomic Language Models with Nucleotide-Level Supervision and Genome Compression

Genomic foundation models aim to learn general-purpose representations directly from DNA sequence, e...

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain

Spatial and activity-dependent gene regulation in the mammalian brain requires coordinated control o...

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