Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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A contextualised protein language model reveals the functional syntax of bacterial evolution

Bacteria have evolved a vast diversity of functions and behaviours which are currently incompletely ...

An Agentic AI Framework for Ingestion and Standardization of Single-Cell RNA-seq Data Analysis

The proliferation of publicly available single-cell RNA sequencing (scRNA-seq) data has created sign...

Reengineering the antigen optimization process for superior neoantigen vaccine design

Identifying effective neoantigen sequences is essential for enhancing anti-tumor immunity. However, ...

A novel deep learning-based framework reveals a continuum of chromatin sensitivities across transcription factors

The genome-wide binding of many transcription factors (TFs) depends not only on the presence of thei...

Generanno: A Genomic Foundation Model for Metagenomic Annotation

The rapid growth of genomic and metagenomic data has underscored the pressing need for advanced comp...

A transformer-based language model reveals developmental constraint and network complexity during zebrafish embryogenesis

Understanding how regulatory complexity and constraint shape organismal development remains a centra...

Leaping over the blood-brain barrier: DNA methylation as a link between peripheral and central immune systems

The majority of existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to re...

Detection of alternative splicing: deep sequencing or deep learning?

Alternative splicing (AS) is a central mechanism of gene regulation that enables condition- and tiss...

DNA Sequence Trace Reconstruction Using Deep Learning

Deciphering DNA sequences is fundamental to unlocking the mysteries of life, but the high dimensiona...

ESPWA: a deep learning-enabled tool for precision-based use of endocrine therapy in resource-limited settings

Cancer morbidity disproportionately affects patients in low- and middle-income countries (LMICs), wh...

A Computational Pipeline for Physiologically Informed Calibration of Ligand Reaction-Diffusion Models Using High-Throughput Sequencing

All physiological processes fundamentally rely on continuous cellular cross-talk to maintain organiz...

ChatMDV: Democratising Bioinformatics Analysis Using Large Language Models

The rapid advancement in single-cell, spatial omics, imaging, and genomic technologies requires robu...

A fully-open structure-guided RNA foundation model for robust structural and functional inference

RNA language models have achieved strong performances across diverse down-stream tasks by leveraging...

DeepRES: Deep learning enables reaction-based comprehensive enzyme screening

Enzymes accelerate biochemical reactions in living organisms, thus playing an important role in meta...

PAM adenine methylation and flanking sequence regulate SaCas9 activity in bacteria

Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to re...

BRAVE: a highly accurate method for predicting HIV-1 antibody resistance using large language models for proteins

Broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) of human immunod...

Machine Learning–Guided Structure–Activity Discovery of Polymer Configurations in Lipid Nanoparticles for Kiss-and-Run Endosomal Escape

Endosomal escape remains a major barrier to effective nucleic acid delivery via lipid nanoparticles ...

Uncovering Developmental Lineages from Single-cell Data with Contrastive Poincaré Maps

Single-cell RNA-sequencing (scRNA-seq) enables the study of hierarchical and branching patterns in o...

The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli

The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteri...

ROSMAP-Compass: a data-harmonised, AI-ready atlas of 22 million single nuclei from the ROSMAP cohort

The Religious Orders Study and Memory and Aging Project (ROSMAP) cohort has generated the world’s mo...

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