Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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MENDELSEEK: An algorithm that predicts Mendelian Genes and elucidates what makes them special

Although individual Mendelian diseases—those caused by a single gene—are rare, their collective dise...

Integrating Protein and DNA Embeddings for Improving Genome-Wide Transcription Factor Binding Site Prediction

Transcription factors (TFs) regulate gene expression by binding to specific DNA sites on genome, mak...

GDEE: A Structure-Based Platform for Gene Discovery and Enzyme Engineering

Enzymes are extensively utilized for catalyzing the production of value-added compounds in diverse s...

BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models

Scientific discovery in the life sciences remains hindered by fragmented workflows, narrow-scope com...

NucleicBERT: Deciphering the language of nucleic acids by a large-language model

The vast majority of the human genome comprises non-protein-coding regions whose structural and func...

PRESTIGE-ST: Patch Resolution and Encoder STrategies for Inference of Gene Expression from Spatial Transcriptomics

Spatial Transcriptomics (ST) integrates histology with spatially resolved gene expression, offering ...

Scalable and interpretable secretion system annotation with Sismis

Secretion systems play critical roles in bacterial growth, survival, and pathogenesis. Genes encodin...

Gene Specific Pathogenicity Predictor for Chromatin-Remodeling BAF Complex-Associated Neurodevelopmental Disorders

Advancements in whole genome sequencing have increased the number of variants of uncertain significa...

Prompt-Driven Target Identification: A Multi-Omics and Network Biology Case Study of PARP1 Using Swalife PromptStudio

Artificial intelligence–assisted scientific prompting is reshaping how biological targets can be rap...

Effects of the Neutral CB1 Receptor Antagonist AM6527 on Spontaneous, Consummatory, and Motivated Behavior in Mice

The cannabinoid type-1 receptor (CB1R) signaling pathway plays a central role in regulating motivati...

A Novel MiRNA Detection System Combining TWJ-SDA, Multistep L-TEAM, and CRISPR-Cas3

MicroRNAs (miRNAs) serve critical regulatory roles in gene expression and are valuable biomarkers fo...

Evaluating the contribution of genome 3D folding to variation in human height using machine learning

Genome-wide association studies (GWAS) have identified thousands of variants associated with complex...

PATTY corrects open chromatin bias for improved bulk and single-cell CUT&Tag profiling

Precise profiling of epigenomes is essential for better understanding chromatin biology and gene reg...

SoluProtMut: Siamese Deep Learning for Predicting Solubility Effects of Protein Mutations with Experimental Validation

Protein solubility is an attractive engineering target because it is a critical property influencing...

Mapping Risk and Conservation Potential Across the Indo-Pacific with Reefshark Genomescapes

Overfishing has severely depleted marine populations worldwide, including within protected areas. Il...

Machine Learning Enables Viral Genome-Agnostic Classification of RNA Virus Infections from Host Transcriptomes

Targeted PCR diagnosis of RNA viruses is sequence dependent, meaning that the accuracy of the assay ...

Single-and double-strand circulating DNA fragmentomics for enhanced cancer detection performance

In early detection of cancer, the use of circulating cell-free DNA (cirDNA) obtained from blood samp...

rpcFold: Residual Parallel Convolutional neural network to decipher RNA folding from RNA sequence

Precise secondary structure information offers deeper insights into the functionality of many RNA mo...

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