Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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An Improved Teaching-Learning-Based Optimization with the Social Character of PSO for Global Optimization.

An improved teaching-learning-based optimization with combining of the social character of PSO (TLBO-PSO), which is considering the teacher's behavior influence on the students and the mean grade of the class, is proposed in the paper to find the global solutions of function optimization problems. In this method, the teacher phase of TLBO is modified; the new position of the individual is determin...

Jan 14 2016 27057157

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.

Several endpoints associated with cellular responses to DNA damage as well as overt cytotoxicity were multiplexed into a miniaturized, "add and read" type flow cytometric assay. Reagents included a detergent to liberate nuclei, RNase and propidium iodide to serve as a pan-DNA dye, fluorescent antibodies against γH2AX, phospho-histone H3, and p53, and fluorescent microspheres for absolute nuclei co...

Jan 13 2016 26764165
Predicting transcription factor site occupancy using DNA sequence intrinsic and cell-type specific chromatin features.

BACKGROUND: Understanding the mechanisms by which transcription factors (TF) are recruited to their physiological target sites is crucial for understa...

Jan 11 2016 26818008
On fuzzy semantic similarity measure for DNA coding.

A coding measure scheme numerically translates the DNA sequence to a time domain signal for protein coding regions identification. A number of coding ...

Dec 31 2015 26773936
Garlic ((Allium sativum)) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2.

Background and aims. There is no report on the apoptotic impact of Allium sativum L.(Garlic) on the oral squamous cell carcinoma (KB); hence, this stu...

Dec 30 2015 26889365
DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.

DNA methyltransferase (MTase) has received a large amount of attention due to its catalyzation of DNA methylation in both eukaryotes and prokaryotes, ...

Dec 29 2015 26807517
Neuro-genetic system for optimization of GMI samples sensitivity.

Magnetic sensors are largely used in several engineering areas. Among them, magnetic sensors based on the Giant Magnetoimpedance (GMI) effect are a ne...

Dec 29 2015 26775132
Development of a quantitative PCR for the detection of Rangelia vitalii.

The aim of this study was to develop and validate a SYBR Green qPCR assay to detect and quantify a fragment of the 18S rRNA gene of Rangelia vitalii i...

Dec 28 2015 26827871
A Biogeography-Based Optimization Algorithm Hybridized with Tabu Search for the Quadratic Assignment Problem.

The quadratic assignment problem (QAP) is an NP-hard combinatorial optimization problem with a wide variety of applications. Biogeography-based optimi...

Dec 27 2015 26819585
Controlling Individuals Growth in Semantic Genetic Programming through Elitist Replacement.

In 2012, Moraglio and coauthors introduced new genetic operators for Genetic Programming, called geometric semantic genetic operators. They have the v...

Dec 27 2015 27057158
Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.

A brain consists of numerous distinct neurons arising from a limited number of progenitors, called neuroblasts in Drosophila. Each neuroblast produces...

Dec 23 2015 26700685
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.

Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology require...

Dec 23 2015 26852843
Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.

The structure of genetic interaction networks predicts that, analogous to synthetic lethal interactions between non-essential genes, combinations of c...

Dec 23 2015 27136353
Isolation and analysis of cell-free fetal DNA from maternal peripheral blood in Chinese women.

Non-invasive prenatal diagnosis is used to detect the genetic material of the fetus by isolating the cell-free fetal DNA (cffDNA) from maternal periph...

Dec 22 2015 26782455
Uncovering low-dimensional, miR-based signatures of acute myeloid and lymphoblastic leukemias with a machine-learning-driven network approach.

Complex phenotypic differences among different acute leukemias cannot be fully captured by analyzing the expression levels of one single molecule, suc...

Dec 21 2015 27274862
Fabrication of highly catalytic silver nanoclusters/graphene oxide nanocomposite as nanotag for sensitive electrochemical immunoassay.

Silver nanoclusters and graphene oxide nanocomposite (AgNCs/GRO) is synthesized and functionalized with detection antibody for highly sensitive electr...

Dec 18 2015 26772127
Efavirenz pharmacogenetics in a cohort of Italian patients.

The pharmacogenetics and pharmacokinetics of efavirenz (EFV) have been widely studied, although data in the Italian population are limited. Single nuc...

Dec 18 2015 26774523
AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation.

Active Hexose Correlated Compound (AHCC) is a fermented mushroom extract and immune supplement that has been used to treat a wide range of health cond...

Dec 15 2015 26788109
Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy.

Anticancer therapy predisposes patients to infections by the immunosuppression that results from treatment. Although 85% of patients with progressive ...

Dec 15 2015 26788389
The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.

Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe. This species is known to have antibacterial...

Dec 14 2015 26788249
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