Genetics

Generative design of synthetic gene circuits for functional and evolutionary properties.

In the past decades, a wide suite of design tools for biological systems has been developed, but usi...

scCAPReSE: detection of large-scale genomic rearrangements from single-cell Hi-C based on few-shot learning.

Large-scale genomic rearrangements are prevalent in cancer genomes and can profoundly rewire three-d...

Comprehensive Multiomics Characterization of Perineural Invasion in Cervical Cancer Reveals Diagnostic Markers, Molecular Drivers, and Therapeutic Strategies.

UNLABELLED: Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is ...

Representation learning of single-cell RNA-seq data.

Single-cell RNA sequencing (scRNA-seq) has become a cornerstone experimental technique in tissue bio...

Deep learning for RNA secondary structure determination: gauging generalizability and broadening the scope of traditional methods.

The diverse regulatory functions, protein production capacity, and stability of natural and syntheti...

Unlocking Enzyme Discovery: A High-Resolution Gene Cluster Database Powered by Phylogenetic Insights and Machine Learning.

High-throughput sequencing has generated vast genomic repositories that remain under-annotated, hamp...

The impact of stability considerations on genetic fine-mapping.

Fine-mapping methods, which aim to identify genetic variants responsible for complex traits followin...

Machine Learning Prediction of Progression to Dialysis in Patients With Polycystic Kidney Disease: Population-Based Retrospective Cohort Study.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst ...

Advances in the laboratory diagnosis of non-viral microbial keratitis.

Infectious keratitis remains a leading cause of corneal blindness and visual impairment worldwide, w...

Drug repurposing in oncology: Bridging computational discovery to clinical application.

Drug repurposing, the identification of new therapeutic applications for existing drugs, has emerged...

Experimental investigation of muscle-tendon unit geometry and kinematics in lower-limb muscles during gait: Current applications and future directions - A scoping review.

PURPOSE: Musculoskeletal (MSK) modeling and ultrasound imaging (USI) are complementary techniques th...

Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.

Disruptions in chromatin remodelers and synaptic proteins represent major genetic risk factors for a...

A collaborative strategy of multi-technology integration for mycotoxin risk assessment and early warning in edible and medicinal plants.

BACKGROUND: Mycotoxins are toxic secondary metabolites of toxigenic fungi, posing a significant thre...

Integrated transcriptomic and metabolomic analysis identifies C5NT1AL as a candidate gene influencing inosine monophosphate levels in chicken breast muscle.

Inosine monophosphate (IMP) is a key umami-related nucleotide that contributes substantially to chic...

EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles.

Transcriptional regulation, critical for cellular differentiation and adaptation to environmental ch...

Integrative Approaches in Lung Cancer Diagnosis: Bridging Molecular Biomarkers and AI Driven Imaging.

Though critical, traditional diagnostic approaches such as X-ray, CT scans, bronchoscopy and tissue ...

Dynamic Electrochemical Reorientation at SERS Hotspots Enables Composition, Length, and Sequence Reading of DNA Oligonucleotides.

Extending surface-enhanced Raman spectroscopy (SERS) from small molecules to macromolecules is impor...

A machine learning framework predicts oncogenic driver mutations from SNP profiles in lung adenocarcinoma.

Homologous recombination deficiency in Ovarian cancer: The game-changer for first-line maintenance therapy.

Homologous recombination deficiency (HRD) plays a central role in the pathogenesis and therapeutic v...

MicroRNAs in penile cancer: challenges, opportunities, and translational perspectives.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and dysregulated miRNA e...

Computational Innovations in Cancer Research and How Computing is Transforming Drug Discovery and Development: A Review.

INTRODUCTION: Cancer is a major global health concern, causing millions of deaths each year due to t...