Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Antiproliferative and Apoptotic Activities of the Medicinal Mushroom Phellinus rimosus (Agaricomycetes) on HCT116 Human Colorectal Carcinoma Cells.

Phellinus rimosus is a host-specific wood-rotting polypore that has been reported to be used by some...

Jan 2018 30806266
[Role of high mobility group protein B1 in 
IL-1α-induced endothelial cell senescence].

To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelia...

Dec 2017 29317575
In vitro assessment of the cytotoxic, DNA damaging, and cytogenetic effects of hydroquinone in human peripheral blood lymphocytes.

This study investigated the mechanisms of hydroquinone toxicity and assessed the relationships betwe...

Dec 2017 29337680
Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.

The discovery of microRNAs (miRNAs) remains an important problem, particularly given the growth of h...

Dec 2017 29036314
Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to incre...

Dec 2017 29036709
Competitive Spiking Neural P Systems With Rules on Synapses.

This paper proposes an extension of spiking neural P systems with rules on synapses (SNP-RS systems)...

Dec 2017 29364132
[Alpinetin promotes the binding of PPAR and methyltransferase].

Objective To screen the nucleus located-methyltransferase in murine macrophages (RAW246.7 cells) aft...

Dec 2017 29382419
[Construction and identification of nanobody phage display library targeting Middle East respiratory syndrome coronavirus].

Objective To construct a phage display library of specific nano-antibodies against the Middle East r...

Dec 2017 29382428
Pycnodysostosis with novel gene mutation and sporadic medullary thyroid carcinoma: A case report.

RATIONALE: Pycnodysostosis is a rare autosomal recessive skeletal dysplasia caused by a mutation in ...

Dec 2017 29390266
DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records.

Precise phenotype information is needed to understand the effects of genetic and epigenetic changes ...

Nov 2017 29092954
Infant Central Nervous System Aspergillosis with First-episode of Intracranial Hemorrhage: A case report.

RATIONALE: Central nervous system (CNS) aspergillosis has the characteristics of multifocality, poly...

Nov 2017 29382019
Partitioned learning of deep Boltzmann machines for SNP data.

MOTIVATION: Learning the joint distributions of measurements, and in particular identification of an...

Oct 2017 28655145
Epigenomic annotation-based interpretation of genomic data: from enrichment analysis to machine learning.

MOTIVATION: One of the goals of functional genomics is to understand the regulatory implications of ...

Oct 2017 29028263
DOMINO: Using Machine Learning to Predict Genes Associated with Dominant Disorders.

In contrast to recessive conditions with biallelic inheritance, identification of dominant (monoalle...

Oct 2017 28985496
DIRECTION: a machine learning framework for predicting and characterizing DNA methylation and hydroxymethylation in mammalian genomes.

MOTIVATION: 5-Methylcytosine and 5-Hydroxymethylcytosine in DNA are major epigenetic modifications k...

Oct 2017 28505334
DNA sequence+shape kernel enables alignment-free modeling of transcription factor binding.

MOTIVATION: Transcription factors (TFs) bind to specific DNA sequence motifs. Several lines of evide...

Oct 2017 28541376
Impact of Clinical Parameters in the Intrahost Evolution of HIV-1 Subtype B in Pediatric Patients: A Machine Learning Approach.

Determining the factors modulating the genetic diversity of HIV-1 populations is essential to unders...

Oct 2017 29044435
Successful treatment with afatinib for pancreatic metastasis of lung adenocarcinoma: a case report.

Metastatic lung cancer of the pancreas is rare and optimal treatment protocols have not been determi...

Oct 2017 29268429
Using neural networks for reducing the dimensions of single-cell RNA-Seq data.

While only recently developed, the ability to profile expression data in single cells (scRNA-Seq) ha...

Sep 2017 28973464
A cargo-sorting DNA robot.

Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm...

Sep 2017 28912216
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