Latest AI and machine learning research in genetics for healthcare professionals.
Pelvic floor disorders, including pelvic organ prolapse and urinary incontinence, represent a common health burden with substantial clinical comorbidity, but their shared genetic architecture remains incompletely understood. We performed a multi-trait genomic analysis of six pelvic-floor-related phenotypes using publicly available GWAS summary statistics from FinnGen R12 and the GWAS Catalog, with...
Inflammatory bowel disease (IBD) is characterized by a refractory, relapsing inflammatory state driven by a multifaceted and poorly understood interplay between host mucosal metabolic disturbances and immune microenvironment dysregulation. To uncover robust non-invasive diagnostic indicators, this study implemented an integrated analytical framework combining advanced machine learning feature sele...
Artificial intelligence (AI) algorithms such as ENLIGHT and DeepPT represent promising approaches to identify predictive biomarkers for immune checkpo...
Nanopores have been explored as a potential platform for protein analysis following the success of nanopore nucleic acid sequencing. However, protein ...
Acute-on-chronic liver failure (ACLF) is characterized by profound metabolic dysfunction and high mortality. Identifying amino acid metabolism-related...
Advances in forensic genomics, which include massively parallel sequencing, dense single nucleotide polymorphism testing, and forensic genetic genealo...
Forensic DNA analysis has already influenced criminal justice, and serves as a powerful tool for both conviction and exoneration. Despite its scientif...
RNA-protein interactions play key roles in many life processes, and their study is significant for understanding gene regulation, revealing disease pa...
BACKGROUND: Computational prediction of drug-target interaction (DTI) is critical for drug discovery and precision medicine. Herein, we constructed a ...
BACKGROUND: Pseudoxanthoma elasticum (PXE) is a hereditary disorder causing progressive arterial mineralization that may cause premature coronary dise...
Pathological Cardiac Hypertrophy (CHT) is a maladaptive response that can lead to heart failure and increase the risk of severe cardiovascular events....
BACKGROUND: The study of cell-free circulating DNA (cirDNA) fragments (fragmentomics) from liquid biopsies has received increasing attention to detect...
Accelerating molecular probe discovery and lead optimization requires accurate and efficient binding affinity prediction. Here we present PBCNet2.0, a...
Sepsis-associated acute lung injury (sepsis-ALI) is a complex pathological condition; its underlying mechanisms remain mostly obscure. Thus, in this s...
Cell-free DNA can be used for early cancer detection, minimal residual disease monitoring, and post-treatment risk stratification. However, current as...
BRAF mutations are key oncogenic alterations across multiple malignancies, including melanoma, thyroid carcinoma, colorectal cancer, non-small cell lu...
Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that improves clinical outcomes in patients with E...
Soil enzyme activity is a key determinant of crop productivity, as it regulates nutrient cycling, organic matter decomposition, and nitrogen transform...
Perihilar cholangiocarcinoma (pCCA) frequently presents as an indeterminate perihilar biliary stricture. The diagnosis is often delayed or uncertain b...
Cancer drug resistance, driven by complex genetic mutations, epigenetic plasticity, and tumor microenvironment interactions, remains the primary cause...