Genetics

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An empirical study of defect clustering in deep neural networks and its implications for testing.

DNN decision logic is vulnerable to adversarial attacks, making robustness testing essential for saf...

(1)
Jul 2026 42386854
Cross-ancestry pleiotropic analysis of imaging-derived phenotypes enhances risk stratification of depression.

Depression arises from dynamic interactions among genetic predisposition, brain alterations, and env...

(2)
Jul 2026 42387104
Full-Spectrum Analysis With Machine Learning for Quantitative Assessment of Lateral Flow Immunoassays: A Platform Approach.

Lateral flow immunoassays (LFIAs) provide rapid point-of-care results but lack quantitative capabili...

(3)
Jul 2026 41284460
Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex.

Protein-protein interactions (PPIs) are shaped by evolutionary pressures that fine-tune binding affi...

(1)
Jul 2026 42246481
A Persistent Homology Approach Enables Single-Cell Detection of Chromatin Spatial Organization Changes During Pathological Senescence Transition.

Chromatin organization changes during aging, accompanied by alterations in higher-order chromosome a...

Jul 2026 42300249
An Aging Clock Based on Immune Repertoire Features: COVID-19 Accelerates Aging.

Aging induces immunosenescence, a progressive decline in immune function underpinning age-related pa...

(1)
Jul 2026 42333941
Deep Unsupervised Domain Adaptation for Translating Cancer Dependency Maps From Cell Lines to Breast Cancer Tumor Genomics.

The Cancer dependency maps (DepMap) identify genetic dependencies in cancer cells using large-scale ...

Jul 2026 42339999
Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Cancer remains a leading cause of death globally, with nearly 10 million deaths in 2020. Advances in...

(1)
Jul 2026 42379586
Metabolic reprogramming of myeloid cells in cancer: from lactate-NAMPT axis to AI-guided therapeutics.

Myeloid cells-including macrophages, monocytes, neutrophils and dendritic cells-are metabolically pl...

(1)
Jul 2026 42380285
An AI-Driven Multi-Omics Framework Identifies CASP8 as a Clinically Actionable Pyroptosis Biomarker in Bladder Cancer.

Despite rapid advances in multi-omics technologies, translating candidate biomarkers into clinical p...

Jul 2026 42387317
Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation.

BACKGROUND/AIM: Colorectal cancer liver metastases (CRLM) remain a leading cause of cancer-related m...

(2)
Jul 2026 42373221
Air pollution and hepatocellular carcinoma: Integrated network toxicology, machine learning, molecular docking and multiomics analysis.

Air pollution is closely related to the incidence and prognosis of hepatocellular carcinoma (HCC); h...

Jun 2026 42428344
Advances in prime editing: Molecular innovations, Large-fragment engineering, and AI-driven design.

Prime editing has rapidly emerged as a versatile and precise genome engineering technology capable o...

Jun 2026 42662231
An optimized dual-branch method for DNA enhancer identification based on pretrained models and multi-scale local regulatory motif extraction.

Accurate identification of enhancer sequences requires concurrent modeling of global contextual info...

Jun 2026 42380424
RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

Despite the groundbreaking advances in deep learning-enabled methods for biomolecular modeling, pred...

Jun 2026 42380508
Elucidating the mechanism of taurine in alleviating osteoarthritis progression based on bioinformatics, machine learning algorithm, and experimental validation.

BACKGROUND: Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation,...

(1)
Jun 2026 42381080
Multi-omics Signature Predicts Anti-EGFR Therapy Benefit in Colorectal Cancer Liver Metastases: A Multi-center Cohort Study.

INTRODUCTION: Clinical management of RAS wild-type colorectal cancer liver metastases (CRLM) remains...

(7)
Jun 2026 42381328
Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

INTRODUCTION: Osteoporosis (OP) is a multifactorial skeletal disorder marked by reduced bone mass an...

(3)
Jun 2026 42381335
Clinical applications of artificial intelligence in autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder lead...

Jun 2026 41591418
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