Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Showing 1072-1092 of 11,060 articles
Toward generalizable predictive models for DNA-encoded libraries.

DNA-encoded libraries (DELs) combined with machine learning (ML) offer a powerful paradigm for hit i...

Feb 2026 41722895
SCMO: a deep learning model integrating the single-cell resolution TME ecosystem and multi-omics for survival prediction in CRC patients.

BACKGROUND: Colorectal cancer (CRC) remains a leading cause of global cancer mortality, highlighting...

Feb 2026 41715092
AI-driven CRISPR screening: optimizing gene editing through automation and intelligent decision support.

BACKGROUND: CRISPR-based genetic screening has become a central methodology in functional genomics, ...

Feb 2026 41715150
Platelets as immune sensors: monitoring immune dynamics and diagnosing disease states across multiple disorders.

BACKGROUND: Beyond their classical roles in haemostasis and thrombosis, platelets have been recognis...

Feb 2026 41719795
Spatial and single-cell transcriptomic atlas of human suprachiasmatic nucleus.

The suprachiasmatic nucleus (SCN) is considered the master pacemaker of the circadian clock in mamma...

Feb 2026 41720090
Label-Free MicroRNA Diagnostics: From CRISPR Nucleases to Nanomaterial-Enhanced Transducers.

Label-free detection of microRNAs (miRNAs) has emerged as a pivotal approach in molecular diagnostic...

Feb 2026 41709870
High-throughput label-free assessment of sperm DNA fragmentation index via intelligent morphological imaging.

Infertility has emerged as an increasingly serious global public health concern, affecting approxima...

Feb 2026 41710949
From fermentation to function: a critical review of lactic acid bacteria redesign for functional foods and precision nutrition.

Lactic acid bacteria (LAB) have transitioned from their traditional roles in food preservation and f...

Feb 2026 41712255
Rapid directed evolution guided by protein language models and epistatic interactions.

Protein engineering is limited by the inefficient search through a high-dimensional sequence space t...

Feb 2026 41712694
A Deep Learning Framework for Comprehensive Prediction of Human RNA G-Quadruplex-Binding Proteins.

MOTIVATION: G-quadruplex-binding proteins (G4BPs) play key roles in RNA metabolism and stress respon...

Feb 2026 41712756
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR.

The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcripti...

Feb 2026 41714417
Guidelines on optimizing DNA methylation reference panels for cell-type deconvolution.

Accurate cell-type deconvolution is critical for correct interpretation of Epigenome-Wide Associatio...

Feb 2026 41708983
PAIRNet: Predicting PIWI cleavage specificity via position-aware RNA interaction modeling.

PIWI proteins maintain genome integrity by piRNA-guided cleavage of complementary RNA targets. While...

Feb 2026 41712585
Uncovering the silent invaders: Dormant tumour cells in the brain microenvironment.

Brain metastasis remains a lethal clinical challenge, largely driven by dormant tumour cells (DTCs)....

Feb 2026 41720323
Concurrent driver mutations induce distinct tumour morphologies on radiological imaging.

BACKGROUND: Most radiogenomic studies examine single driver mutations in isolation, despite evidence...

Feb 2026 41759448
Scaling genomic reanalysis to unlock diagnoses and transform rare disease care.

Genomic reanalysis can identify causative variants for rare diseases as patient phenotypes evolve an...

Feb 2026 41715921
Conformation-programmed DNA computing.

Natural biological systems achieve precise cellular control through multidimensional signaling archi...

Feb 2026 41706864
A universal indel filtering workflow for both long-read and short-read NGS data.

Accurate detection of insertions and deletions (indels) is critical for applications in disease geno...

Feb 2026 41709342
Novel Lipid Nanoparticle (LNP) Delivery Systems Enabling the Advancement of RNA Therapeutics.

Lipid nanoparticle (LNP)-mRNA technology has profoundly transformed the biomedical landscape, establ...

Feb 2026 41709402
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